James R. Brown - Böcker

When genomic research first came on the scene, much of the biomedical research community viewed it as a limited venture with limited potential. We now know that such an assessment was both highly premature and wonderfully inaccurate. In the last ten years, we’ve witnessed such remarkable acceleration in the merger of basic and applied genomic research that, among other things, genomic research is now thought of as being intrinsic to current drug research. Through rigorous comparative analysis, the genomes of cold-blooded vertebrate, avian, and other mammalian species are providing a deeper understanding of the human genome. Moreover, genomic sequences, which are becoming available for several species have proven to be highly relevant to drug research with regard to a number of otherwise intractable conditions.Rather than offering a comprehensive volume covering every aspect of comparative genomics, Comparative Genomics: Basic and Applied Research embodies the diverse interests of prominent researchers in the field. Compiling first hand descriptions of their pioneering work, the text focuses on commonalities and synergies across the broad field of comparative genomics. Among its many topics it covers— · Revolutionary advances in DNA-sequencing technology · Bold new approaches to the organization and analysis of large phylogenetic data sets · The impact of comparative genomics on our understanding of evolution · Efforts toward developing novel antimicrobial drugs, through the use of bacterial pathogen genomes Ultimately, future breakthroughs in comparative genomics will depend upon the continued interaction and interdependency of applied and basic research. This seminal volume demonstrates both the means and the fruits of that cooperation, and in doing so defines and lays the groundwork for continued progress.

Distribution channels are the most complex element of the marketing mix to fully grasp and to profitably manage. In this Handbook the authors present cutting-edge research on channel management and design from analytical, conceptual, and empirical perspectives. The ultimate objective of this Handbook is a comprehensive theory of distribution channels for scholars presented in enlightened surveys of the literature to tightly reasoned investigations. Channel management topics include value creation, interorganizational knowledge transfer, contract design, governance and control, and relationship management. Channel design topics encompass coordination, supply-chain management, price vs. quantity competition, channel breadth, franchising, resale price maintenance, and bricks-and-mortar vs. online retailer competition. The book concludes with a sketch of a ''Comprehensive Theory of Distribution Channels'' meant to incorporate and extend current thinking. The breadth of this Handbook makes it appropriate for use in a doctoral course on distribution channels, or as a knowledge-broadening resource for faculty and researchers who wish to understand types of channels research that are outside the scope of their own approach to distribution.Contributors include: K.D. Antia, B.L. Baker, P. Bicen, C.P. Blocker, J.R. Brown, G. Cai, N.N. Chau, S.C. Choi, J.L. Crosno, T.H. Cui, Y. Dai, R.P. Dant, R. Desiraju, K. Eshghi, D.J. Flint, K.M. Frias, M. Ghosh, S. Gilbert, G.T. Gundlach, C.M. Harmeling, J.D. Hibbard, M.B. Houston, C.A. Ingene, K. Jerath, G. John, J. Johnson, M. Kacker, G. Lai, Z. Li, R.F. Lusch, P. Mallucci, A.J. Malter, S. Mani, A.L. Matthews, R.W. Palmatier, S.-J. Park, R.E. Paul, J. Raju, S. Ray, F. Sadeh, R.S. Sohi, J.M. Song, R. Staelin, A.S. Vinhas, M. Viswanathan, K.H. Wathne, S.K. Weaven, X. Xu, W. Zhang, Z.J. Zhang, Y. Zhao