Mark Horowitz – författare

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13 produkter

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13 produkter

Maudsley Deprescribing Guidelines
Antidepressants, Benzodiazepines, Gabapentinoids and Z-drugs
AvMark Horowitz,David M. Taylor
Häftad, Engelska, 2024
704 kr
Skickas inom 5-8 vardagar
The Maudsley® Deprescribing Guidelines Comprehensive resource describing guidelines for safely reducing or stopping (deprescribing) antidepressants, benzodiazepines, gabapentinoids and z-drugs for patients, including step-by-step guidance for all commonly used medications, covering common pitfalls, troubleshooting, supportive strategies, and more.Most formal guidance on psychiatric medication relates to starting or switching medications with minimal guidance on deprescribing medication. In 2023, the World Health Organisation and the United Nations called for patients, as a human right, to be informed of their right to discontinue treatment and to receive support to do so.The Maudsley Deprescribing Guidelines fills a significant gap in guidance for clinicians by providing comprehensive and authoritative information on this important aspect of treatment.This evidence-based handbook provides an overview of principles to be used in deprescribing. This is derived from fundamental scientific principles and the latest research on this topic, combined with emerging insights from clinical practice (including from patient experts).Building on the recognised brand of The Maudsley Prescribing Guidelines, and the prominence of the authors’ work, including in The Lancet Psychiatry on tapering antidepressants (the most read article across all Lancet titles when it was released). The Maudsley Deprescribing Guidelines covers topics such as: Why and when to deprescribe antidepressants, benzodiazepines, gabapentinoids and z-drugsBarriers and enablers to deprescribing including physical dependence, social circumstances, and knowledge about the discontinuation processDistinguishing withdrawal symptoms, such as poor mood, anxiety, insomnia, and a variety of physical symptoms from symptoms of the underlying disorder that medication was intended to treatThe difference between physical dependence and addiction/substance use disorderExplanation of why and how to implement hyperbolic tapering in clinical practiceSpecific guidance on formulations of medication and techniques for making gradual reductions, including using liquid forms of medication, and other approachesStep-by-step guidance for safely stopping all commonly used antidepressants, benzodiazepines, gabapentinoids and z-drugs, including fast, moderate and slow tapering regimens or schedules for each drug, and guidance on how to tailor these to an individualTroubleshooting issues which can arise on stopping these medications, including akathisia, withdrawal symptoms, acute or protracted, and relapse.Written for anyone interested in safe deprescribing of psychiatric medications including psychiatrists, GPs, pharmacists, nurses, medical trainees, and interested members of the public. The Maudsley Deprescribing Guidelines is an essential resource on the subject that provides practical guidance on how to improve patient outcomes in this field of medicine.
Osteoimmunology
Interactions of the Immune and Skeletal Systems
AvHiroshi Takayanagi,Yongwon Choim. fl.
E-bok
Engelska, 2010
1 035 kr
Läs direkt efter köp
Bone and the immune system are both complex tissues, which, respectively, regulate the skeleton and the body''s responses to invading pathogens. Critical interactions between these two organ systems frequently occur, particularly in the development of immune cells in the bone marrow and for the function of bone cells in health and disease. This book provides a detailed overview of the many ways that bone and immune cells interact. The goal is to provide basic and clinical scientists with a better understanding of the role that the immune system and bone play in the development and function of each other so that advances in both fields will be facilitated. The focus of the book will be both on basic pathways and translational science, which will apply basic knowledge to clinical diseases. Chapter content will range from basic descriptions of the various cell systems and their development to the signals that cause them to interact during normal physiology and disease. This is a rapidly developing area that is of interest to a wide spectrum of researchers, students, and fellows in immunology, rheumatology, hematology, and bone biology--all of whom need to develop a more complete understanding of their previously separate disciplines and the mechanisms by which they interact.- Presents a comprehensive, translational source for all aspects of osteoimmunology in one reference work- Experts in bone biology and immunology (from all areas of academic and medical research) take readers from the bench research (cellular and molecular mechanism), through genomic and proteomic analysis, all the way to clinical analysis (histopathology and imaging) and new therapeutic approaches- Clear presentations by bone biologists of the cellular and molecular mechanisms underlying bone cell development leading to bone and immunological diseases such as Lupus- Clear presentations by immunologists of how immune cells develop and how the immune system plays a role in bone diseases like osteoporosis and arthritis
Osteoimmunology
Interactions of the Immune and Skeletal Systems
AvJoseph Lorenzo,Mark Horowitzm. fl.
Inbunden, Engelska, 2015
1 342 kr
Skickas inom 10-15 vardagar
Osteoimmunology: Interactions of the Immune and Skeletal Systems, Second Edition, explores the advancements that have been made in the field during the last 40 years, including valuable information on our understanding of the interactions between hematopoietic, immune, and bone cells, now known as the field of osteoimmunology.

This comprehensive work offers the most extensive summaries of research trends in the field and their translation into new therapeutics.

Early chapters deal with the development of osteoblasts, osteoclasts, hematopoietic stem cells, T and B-lymphocytes, and communications between these cellular elements, while later sections contain discussions of the signaling pathways by which RANKL influences osteoclast development and function. Subsequent chapters explore the effects that estrogen has on bone and the immune system, the development of pathologic conditions, and the growing research around osteoporosis, Paget's disease, the genetics of bone disease, and bone cancer metastasis.
Explains the intricate interaction between the immune system and bone Features detailed discussions of the key cellular and molecular mechanisms governing the homeostasis of the individual systems Facilitates greater understanding of osteoimmunologic networks, their environments, and how this understanding leads to better treatments for human diseases involving both systems
Osteoimmunology
Interactions of the Immune and Skeletal Systems
AvGeorg Schett,Hiroshi Takayanagim. fl.
E-bok
Engelska, 2015
1 755 kr
Läs direkt efter köp
Osteoimmunology: Interactions of the Immune and Skeletal Systems, Second Edition, explores the advancements that have been made in the field during the last 40 years, including valuable information on our understanding of the interactions between hematopoietic, immune, and bone cells, now known as the field of osteoimmunology.This comprehensive work offers the most extensive summaries of research trends in the field and their translation into new therapeutics.Early chapters deal with the development of osteoblasts, osteoclasts, hematopoietic stem cells, T and B-lymphocytes, and communications between these cellular elements, while later sections contain discussions of the signaling pathways by which RANKL influences osteoclast development and function. Subsequent chapters explore the effects that estrogen has on bone and the immune system, the development of pathologic conditions, and the growing research around osteoporosis, Paget''s disease, the genetics of bone disease, and bone cancer metastasis.- Explains the intricate interaction between the immune system and bone- Features detailed discussions of the key cellular and molecular mechanisms governing the homeostasis of the individual systems- Facilitates greater understanding of osteoimmunologic networks, their environments, and how this understanding leads to better treatments for human diseases involving both systems
Quantum Computing
Progress and Prospects
AvCommittee on Technical Assessment of the Feasibility and Implications of Quantum Computing,Computer Science and Telecommunications Boardm. fl.
E-bok
Engelska, 2019
777 kr
Läs direkt efter köp
Quantum mechanics, the subfield of physics that describes the behavior of very small (quantum) particles, provides the basis for a new paradigm of computing. First proposed in the 1980s as a way to improve computational modeling of quantum systems, the field of quantum computing has recently garnered significant attention due to progress in building small-scale devices. However, significant technical advances will be required before a large-scale, practical quantum computer can be achieved.
Quantum Computing: Progress and Prospects provides an introduction to the field, including the unique characteristics and constraints of the technology, and assesses the feasibility and implications of creating a functional quantum computer capable of addressing real-world problems. This report considers hardware and software requirements, quantum algorithms, drivers of advances in quantum computing and quantum devices, benchmarks associated with relevant use cases, the time and resources required, and how to assess the probability of success.
Dance of We
The Mindful Use of Love and Power in Human Systems
AvMark Horowitz
Häftad, Engelska, 2014
258 kr
Skickas inom 5-8 vardagar
Maudsley Deprescribing Guidelines
Antidepressants, Benzodiazepines, Gabapentinoids and Z-drugs
AvDavid M. Taylor,Mark Horowitz
E-bok
PDF, Engelska, 2024
847 kr
Läs direkt efter köp
The Maudsley® Deprescribing Guidelines
Comprehensive resource describing guidelines for safely reducing or stopping (deprescribing) antidepressants, benzodiazepines, gabapentinoids and z-drugs for patients, including step-by-step guidance for all commonly used medications, covering common pitfalls, troubleshooting, supportive strategies, and more.
Most formal guidance on psychiatric medication relates to starting or switching medications with minimal guidance on deprescribing medication. In 2023, the World Health Organisation and the United Nations called for patients, as a human right, to be informed of their right to discontinue treatment and to receive support to do so.
The Maudsley Deprescribing Guidelines fills a significant gap in guidance for clinicians by providing comprehensive and authoritative information on this important aspect of treatment.
This evidence-based handbook provides an overview of principles to be used in deprescribing. This is derived from fundamental scientific principles and the latest research on this topic, combined with emerging insights from clinical practice (including from patient experts).
Building on the recognised brand of The Maudsley Prescribing Guidelines, and the prominence of the authors’ work, including in The Lancet Psychiatry on tapering antidepressants (the most read article across all Lancet titles when it was released). The Maudsley Deprescribing Guidelines covers topics such as:
Why and when to deprescribe antidepressants, benzodiazepines, gabapentinoids and z-drugs Barriers and enablers to deprescribing including physical dependence, social circumstances, and knowledge about the discontinuation process Distinguishing withdrawal symptoms, such as poor mood, anxiety, insomnia, and a variety of physical symptoms from symptoms of the underlying disorder that medication was intended to treat The difference between physical dependence and addiction/substance use disorder Explanation of why and how to implement hyperbolic tapering in clinical practice Specific guidance on formulations of medication and techniques for making gradual reductions, including using liquid forms of medication, and other approaches Step-by-step guidance for safely stopping all commonly used antidepressants, benzodiazepines, gabapentinoids and z-drugs, including fast, moderate and slow tapering regimens or schedules for each drug, and guidance on how to tailor these to an individual Troubleshooting issues which can arise on stopping these medications, including akathisia, withdrawal symptoms, acute or protracted, and relapse.
Written for anyone interested in safe deprescribing of psychiatric medications including psychiatrists, GPs, pharmacists, nurses, medical trainees, and interested members of the public. The Maudsley Deprescribing Guidelines is an essential resource on the subject that provides practical guidance on how to improve patient outcomes in this field of medicine.
Maudsley Deprescribing Guidelines
Antidepressants, Benzodiazepines, Gabapentinoids and Z-drugs
AvDavid M. Taylor,Mark Horowitz
E-bok
Engelska, 2024
853 kr
Läs direkt efter köp
The Maudsley® Deprescribing Guidelines
Comprehensive resource describing guidelines for safely reducing or stopping (deprescribing) antidepressants, benzodiazepines, gabapentinoids and z-drugs for patients, including step-by-step guidance for all commonly used medications, covering common pitfalls, troubleshooting, supportive strategies, and more.
Most formal guidance on psychiatric medication relates to starting or switching medications with minimal guidance on deprescribing medication. In 2023, the World Health Organisation and the United Nations called for patients, as a human right, to be informed of their right to discontinue treatment and to receive support to do so.
The Maudsley Deprescribing Guidelines fills a significant gap in guidance for clinicians by providing comprehensive and authoritative information on this important aspect of treatment.
This evidence-based handbook provides an overview of principles to be used in deprescribing. This is derived from fundamental scientific principles and the latest research on this topic, combined with emerging insights from clinical practice (including from patient experts).
Building on the recognised brand of The Maudsley Prescribing Guidelines, and the prominence of the authors’ work, including in The Lancet Psychiatry on tapering antidepressants (the most read article across all Lancet titles when it was released). The Maudsley Deprescribing Guidelines covers topics such as:
Why and when to deprescribe antidepressants, benzodiazepines, gabapentinoids and z-drugs Barriers and enablers to deprescribing including physical dependence, social circumstances, and knowledge about the discontinuation process Distinguishing withdrawal symptoms, such as poor mood, anxiety, insomnia, and a variety of physical symptoms from symptoms of the underlying disorder that medication was intended to treat The difference between physical dependence and addiction/substance use disorder Explanation of why and how to implement hyperbolic tapering in clinical practice Specific guidance on formulations of medication and techniques for making gradual reductions, including using liquid forms of medication, and other approaches Step-by-step guidance for safely stopping all commonly used antidepressants, benzodiazepines, gabapentinoids and z-drugs, including fast, moderate and slow tapering regimens or schedules for each drug, and guidance on how to tailor these to an individual Troubleshooting issues which can arise on stopping these medications, including akathisia, withdrawal symptoms, acute or protracted, and relapse.
Written for anyone interested in safe deprescribing of psychiatric medications including psychiatrists, GPs, pharmacists, nurses, medical trainees, and interested members of the public. The Maudsley Deprescribing Guidelines is an essential resource on the subject that provides practical guidance on how to improve patient outcomes in this field of medicine.
Maudsley Deprescribing Guidelines in Psychiatry
Antipsychotics, Mood Stabilisers, Opioids and Stimulants
AvMark Horowitz,David Taylor
Häftad, Engelska, 2027
654 kr
Kommande
I Wish I Knew Then What I Know Now
A Guide for Special Needs Parents
AvMark Horowitz,Sandy Horowitzm. fl.
Häftad, Engelska, 2013
180 kr
Skickas inom 5-8 vardagar
The Dream Rule
AvMark Horowitz
Häftad, Engelska
257 kr
Skickas inom 3-6 vardagar
Compiling Algorithms for Heterogeneous Systems
AvSteven Bell,Jing Pum. fl.
Inbunden, Engelska, 2018
564 kr
Skickas inom 10-15 vardagar
Most emerging applications in imaging and machine learning must perform immense amounts of computation while holding to strict limits on energy and power. To meet these goals, architects are building increasingly specialized compute engines tailored for these specific tasks. The resulting computer systems are heterogeneous, containing multiple processing cores with wildly different execution models. Unfortunately, the cost of producing this specialized hardware—and the software to control it—is astronomical. Moreover, the task of porting algorithms to these heterogeneous machines typically requires that the algorithm be partitioned across the machine and rewritten for each specific architecture, which is time consuming and prone to error.Over the last several years, the authors have approached this problem using domain-specific languages (DSLs): high-level programming languages customized for specific domains, such as database manipulation, machine learning, or image processing. By giving up generality, these languages are able to provide high-level abstractions to the developer while producing high-performance output. The purpose of this book is to spur the adoption and the creation of domain-specific languages, especially for the task of creating hardware designs.In the first chapter, a short historical journey explains the forces driving computer architecture today. Chapter 2 describes the various methods for producing designs for accelerators, outlining the push for more abstraction and the tools that enable designers to work at a higher conceptual level. From there, Chapter 3 provides a brief introduction to image processing algorithms and hardware design patterns for implementing them. Chapters 4 and 5 describe and compare Darkroom and Halide, two domain-specific languages created for image processing that produce high-performance designs for both FPGAs and CPUs from the same source code, enabling rapid design cycles and quick porting of algorithms. The final section describes how the DSL approach also simplifies the problem of interfacing between application code and the accelerator by generating the driver stack in addition to the accelerator configuration.This book should serve as a useful introduction to domain-specialized computing for computer architecture students and as a primer on domain-specific languages and image processing hardware for those with more experience in the field.
Compiling Algorithms for Heterogeneous Systems
AvMark Horowitz,James Hegartym. fl.
E-bok
PDF, Engelska, 2022
718 kr
Läs direkt efter köp
Most emerging applications in imaging and machine learning must perform immense amounts of computation while holding to strict limits on energy and power. To meet these goals, architects are building increasingly specialized compute engines tailored for these specific tasks. The resulting computer systems are heterogeneous, containing multiple processing cores with wildly different execution models. Unfortunately, the cost of producing this specialized hardware—and the software to control it—is astronomical. Moreover, the task of porting algorithms to these heterogeneous machines typically requires that the algorithm be partitioned across the machine and rewritten for each specific architecture, which is time consuming and prone to error.
Over the last several years, the authors have approached this problem using domain-specific languages (DSLs): high-level programming languages customized for specific domains, such as database manipulation, machine learning, or image processing. By giving up generality, these languages are able to provide high-level abstractions to the developer while producing high-performance output. The purpose of this book is to spur the adoption and the creation of domain-specific languages, especially for the task of creating hardware designs.
In the first chapter, a short historical journey explains the forces driving computer architecture today. Chapter 2 describes the various methods for producing designs for accelerators, outlining the push for more abstraction and the tools that enable designers to work at a higher conceptual level. From there, Chapter 3 provides a brief introduction to image processing algorithms and hardware design patterns for implementing them. Chapters 4 and 5 describe and compare Darkroom and Halide, two domain-specific languages created for image processing that produce high-performance designs for both FPGAs and CPUs from the same source code, enabling rapid design cycles and quick porting of algorithms. The final section describes how the DSL approach also simplifies the problem of interfacing between application code and the accelerator by generating the driver stack in addition to the accelerator configuration.
This book should serve as a useful introduction to domain-specialized computing for computer architecture students and as a primer on domain-specific languages and image processing hardware for those with more experience in the field.

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Mark Horowitz – författare

Maudsley Deprescribing Guidelines

Osteoimmunology

Osteoimmunology

Osteoimmunology

Quantum Computing

Dance of We

Maudsley Deprescribing Guidelines

Maudsley Deprescribing Guidelines

Maudsley Deprescribing Guidelines in Psychiatry

I Wish I Knew Then What I Know Now

The Dream Rule

Compiling Algorithms for Heterogeneous Systems

Compiling Algorithms for Heterogeneous Systems

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