Santosh Kumar Singh – författare

Drug Delivery and Biomedical Applications of Porous Silicon-Based Nanocarriers delivers an up-to-date and complete overview of the range of biomedical applications for porous silicon nanomaterials, with a special emphasis on drug delivery. This book introduces the fundamentals and beneficial properties of porous silicon, including thermal properties and stabilization, photochemical and nonthermal chemical modification, protein modification, and biocompatibility. The book then builds on the systematic detailing of each biomedical application using porous silicon, such as vaccine development, drug delivery, and tissue engineering. It also contains new insights on in-vivo assessment of porous silicon, photodynamic and photothermal therapy, micro- and nanoneedles, cancer immunotherapy, and more. Drug Delivery and Biomedical Applications of Porous Silicon-Based Nanocarriers is of interest to researchers in the fields of materials science, nanotechnology, pharmaceutical science, biomedical engineering, and cancer research.Details synthesis approaches and methodologies for porous silicon-based nanocarriers, enabling structural understanding and therapeutic applicationsHighlights the role of silica nanoparticles in targeted drug delivery, emphasizing their impact on cancer therapy, immunotherapy, neurodegenerative disorders, and other biomedical applicationsExplores clinical aspects and trials of silica nanoparticles for treatment options

Drug Delivery and Biomedical Applications of Porous Silicon-Based Nanocarriers delivers an up-to-date and complete overview of the range of biomedical applications for porous silicon nanomaterials, with a special emphasis on drug delivery. This book introduces the fundamentals and beneficial properties of porous silicon, including thermal properties and stabilization, photochemical and nonthermal chemical modification, protein modification, and biocompatibility. The book then builds on the systematic detailing of each biomedical application using porous silicon, such as vaccine development, drug delivery, and tissue engineering. It also contains new insights on in-vivo assessment of porous silicon, photodynamic and photothermal therapy, micro- and nanoneedles, cancer immunotherapy, and more. Drug Delivery and Biomedical Applications of Porous Silicon-Based Nanocarriers is of interest to researchers in the fields of materials science, nanotechnology, pharmaceutical science, biomedical engineering, and cancer research. - Details synthesis approaches and methodologies for porous silicon-based nanocarriers, enabling structural understanding and therapeutic applications- Highlights the role of silica nanoparticles in targeted drug delivery, emphasizing their impact on cancer therapy, immunotherapy, neurodegenerative disorders, and other biomedical applications- Explores clinical aspects and trials of silica nanoparticles for treatment options

Nanogels: Fundamentals to Pharmaceutical and Biomedical Applications provides a comprehensive overview of nanogels, focusing on design principles, crosslinking methods, and therapeutic agent delivery. It covers nanogels' thermal properties, stabilization, chemical modifications, and biocompatibility. The book details biomedical applications, including bioimaging, sensing, drug delivery, and tissue engineering. It also explores in-vivo assessments, responsive therapies, and safety considerations, including toxicity, clearance mechanisms, and immunological responses, offering new insights into nanogel technology.Nanogels: Fundamentals to Pharmaceutical and Biomedical Applications offers an exciting look into this emerging area and is of particular interest to healthcare professionals and researchers working on nanocarrier-based drug delivery, focusing on porous nanogel nanocarriers.Describes the current and future prospective of biomedical applications of nanogels, emphasizing their role in drug delivery, targeted therapy, imaging, diagnostics, and tissue engineering. Explores their potential to address critical healthcare challenges, serving as a valuable resource for researchers and practitionersDelivers a fully updated and complete overview of the range of biomedical applications for nanogelsExplores cutting-edge nanogel research and emerging trends, offering future insights while addressing toxicity assessment, clearance mechanisms, and long-term effects to ensure safe biomedical applications of these innovative materials

Nanogels: Fundamentals to Pharmaceutical and Biomedical Applications provides a comprehensive overview of nanogels, focusing on design principles, crosslinking methods, and therapeutic agent delivery. It covers nanogels'' thermal properties, stabilization, chemical modifications, and biocompatibility. The book details biomedical applications, including bioimaging, sensing, drug delivery, and tissue engineering. It also explores in-vivo assessments, responsive therapies, and safety considerations, including toxicity, clearance mechanisms, and immunological responses, offering new insights into nanogel technology.Nanogels: Fundamentals to Pharmaceutical and Biomedical Applications offers an exciting look into this emerging area and is of particular interest to healthcare professionals and researchers working on nanocarrier-based drug delivery, focusing on porous nanogel nanocarriers.- Describes the current and future prospective of biomedical applications of nanogels, emphasizing their role in drug delivery, targeted therapy, imaging, diagnostics, and tissue engineering. Explores their potential to address critical healthcare challenges, serving as a valuable resource for researchers and practitioners- Delivers a fully updated and complete overview of the range of biomedical applications for nanogels- Explores cutting-edge nanogel research and emerging trends, offering future insights while addressing toxicity assessment, clearance mechanisms, and long-term effects to ensure safe biomedical applications of these innovative materials

Advancements in Modeling-Based Therapeutics and Technology for Chronic Diseases delves into the crucial role of animal and cellular models in comprehending the intricate mechanisms of chronic diseases. The book emphasizes the importance of these models in predicting disease progression, testing new therapeutic approaches, and understanding how environmental and genetic factors interplay in the development of long-term health conditions. With a multidisciplinary approach, it bridges the gap between experimental research and clinical applications, offering insights into not only disease management but also the future of personalized medicine.The book also sheds light on emerging technologies, including bioinformatics tools and in silico modeling, which further enhance our ability to tackle chronic diseases. It explores how these advancements are transforming research methodologies and providing novel solutions for diagnosis and treatment. Additionally, it highlights collaborative strategies between researchers, clinicians, and technologists, stressing the importance of integrated efforts in addressing global health challenges effectively.Delves into detailed case studies, methodologies, and emerging trends, providing an in-depth review of current modeling approachesExplores the integration of various technologies, offering a holistic view of how these technologies can be applied synergisticallySheds light on how current technological innovations are integrated into therapeutic approaches for chronic disease management

Advancements in Modeling-Based Therapeutics and Technology for Chronic Diseases delves into the crucial role of animal and cellular models in comprehending the intricate mechanisms of chronic diseases. The book emphasizes the importance of these models in predicting disease progression, testing new therapeutic approaches, and understanding how environmental and genetic factors interplay in the development of long-term health conditions. With a multidisciplinary approach, it bridges the gap between experimental research and clinical applications, offering insights into not only disease management but also the future of personalized medicine.The book also sheds light on emerging technologies, including bioinformatics tools and in silico modeling, which further enhance our ability to tackle chronic diseases. It explores how these advancements are transforming research methodologies and providing novel solutions for diagnosis and treatment. Additionally, it highlights collaborative strategies between researchers, clinicians, and technologists, stressing the importance of integrated efforts in addressing global health challenges effectively. - Delves into detailed case studies, methodologies, and emerging trends, providing an in-depth review of current modeling approaches- Explores the integration of various technologies, offering a holistic view of how these technologies can be applied synergistically- Sheds light on how current technological innovations are integrated into therapeutic approaches for chronic disease management

This reference book provides a comprehensive overview of models and therapeutic approaches against neurodegenerative diseases, including Parkinson’s disease, Alzheimer’s disease, Huntington’s disease, and amyotrophic lateral sclerosis. It explores models based on the chemical, induced, cellular, genetic, transgenic, and 3D organoid approaches in neurodegenerative diseases. The book also reviews advantages and limitations of these models in designing the treatment strategies. Additionally, the book covers the emerging field of bioinformatics and its application in modeling various neurodegenerative diseases. Towards the end, the book highlights the role of holistic management, precision medicine, OMICS, and gene therapy against neurodegenerative disorders. It examines the implications and significance of stem cells therapy in translational models of neurodegenerative diseases. This book is an invaluable resource for researchers, neuroscientists, and neurosurgeons for getting in-depth information on the neurodegenerative models and therapeutic approaches.Key Features:Provides a comprehensive overview of neurodegenerative diseases and their modelsExamines the limitations associated with modeling neurodegenerative diseasesPresents novel treatment strategies for Alzheimer's disease using cellular modelsReviews importance of 3D organoid models for therapeutic approaches in Parkinson's diseaseCovers modeling techniques in understanding prion diseasesExplores the role of genetic models in understanding Huntington's disease

This book explores the pivotal role of synaptic plasticity in the pathogenesis, progression, and potential treatment of neurodegenerative disorders. The initial chapter provides an in-depth understanding of the complexity and impact of neurodegenerative conditions. It discusses the association of mitochondrial dysfunction, epigenetic influences, and neuroinflammation with synaptic plasticity in neurodegenerative diseases. The following chapters review the dynamic changes that occur at the cellular and synaptic levels in Parkinson's disease, Alzheimer's disease, and Huntington's disease, paving the way for innovative therapeutic strategies. Furthermore, the book presents various computational tools and methodologies essential for enhancing our understanding of synaptic plasticity. It examines the transformative role of artificial intelligence tools in addressing synaptic impairment across various neurodegenerative diseases.Discusses the role of synaptic plasticity in neurodegenerative diseases, shedding light on how dynamic changes occur at the cellular and synaptic levelsExplores the transformative role of artificial intelligence tools in addressing synaptic impairment across various neurodegenerative diseasesProvides a comprehensive overview of neurodegenerative disorders, including pathogenesis, etiology, and treatment strategiesPresents tools and techniques used to simulate the complex system biology of synaptic plasticityExamines the role of computational neuroscience in understanding and potentially treating conditions such as multiple sclerosis and amyotrophic lateral sclerosisToward the end, the book explores the role of synaptic impairment and computational neuroscience in understanding and potentially treating conditions such as multiple sclerosis and amyotrophic lateral sclerosis. With its multifaceted approach, this book serves as a useful resource for researchers, clinicians, and students in the fields of neuroscience, computational biology, and neurology.

This book delves into the complexities of brain health, aging, and neurodegeneration, exploring the varied roles that genetic, environmental, and lifestyle factors play in shaping brain health. It examines their contributions to the development and progression of neurodegenerative diseases. The opening chapters introduce the concept of the blood–brain barrier and its crucial role in maintaining brain health. It also discusses how this barrier is compromised with aging and in various neurodegenerative diseases, underscoring its importance in understanding disease progression. The book reviews specific conditions, including Alzheimer's disease and Parkinson's disease, analyzes their underlying mechanisms, and presents a range of pharmacological and nonpharmacological treatments, along with emerging therapies that offer hope for the future. It also explores other neurodegenerative diseases, such as ALS, Huntington's disease, and multiple sclerosis, detailing the unique pathways that lead to neurodegeneration and the latest approaches to treatment. The chapters provide insights into brain biomarkers and diagnostic techniques that help with early detection and diagnosis of neurodegenerative conditions. Toward the end, the book discusses the challenges faced by patients and caregivers and offers strategies for support and coping. This book serves as an essential resource for neuroscientists and neurologists.

This reference book provides a comprehensive overview of models and therapeutic approaches against neurodegenerative diseases, including Parkinson’s disease, Alzheimer’s disease, Huntington’s disease, and amyotrophic lateral sclerosis. It explores models based on the chemical, induced, cellular, genetic, transgenic, and 3D organoid approaches in neurodegenerative diseases. The book also reviews advantages and limitations of these models in designing the treatment strategies. Additionally, the book covers the emerging field of bioinformatics and its application in modeling various neurodegenerative diseases. Towards the end, the book highlights the role of holistic management, precision medicine, OMICS, and gene therapy against neurodegenerative disorders. It examines the implications and significance of stem cells therapy in translational models of neurodegenerative diseases. This book is an invaluable resource for researchers, neuroscientists, and neurosurgeons for getting in-depth information on the neurodegenerative models and therapeutic approaches.

Key Features:

Provides a comprehensive overview of neurodegenerative diseases and their models Examines the limitations associated with modeling neurodegenerative diseases Presents novel treatment strategies for Alzheimer''s disease using cellular models Reviews importance of 3D organoid models for therapeutic approaches in Parkinson''s disease Covers modeling techniques in understanding prion diseases Explores the role of genetic models in understanding Huntington''s disease

This reference book provides a comprehensive overview of models and therapeutic approaches against neurodegenerative diseases, including Parkinson’s disease, Alzheimer’s disease, Huntington’s disease, and amyotrophic lateral sclerosis. It explores models based on the chemical, induced, cellular, genetic, transgenic, and 3D organoid approaches in neurodegenerative diseases. The book also reviews advantages and limitations of these models in designing the treatment strategies. Additionally, the book covers the emerging field of bioinformatics and its application in modeling various neurodegenerative diseases. Towards the end, the book highlights the role of holistic management, precision medicine, OMICS, and gene therapy against neurodegenerative disorders. It examines the implications and significance of stem cells therapy in translational models of neurodegenerative diseases. This book is an invaluable resource for researchers, neuroscientists, and neurosurgeons for getting in-depth information on the neurodegenerative models and therapeutic approaches.

Key Features:

Provides a comprehensive overview of neurodegenerative diseases and their models Examines the limitations associated with modeling neurodegenerative diseases Presents novel treatment strategies for Alzheimer''s disease using cellular models Reviews importance of 3D organoid models for therapeutic approaches in Parkinson''s disease Covers modeling techniques in understanding prion diseases Explores the role of genetic models in understanding Huntington''s disease

This book explores the pivotal role of synaptic plasticity in the pathogenesis, progression, and potential treatment of neurodegenerative disorders. The initial chapter provides an in-depth understanding of the complexity and impact of neurodegenerative conditions. It discusses the association of mitochondrial dysfunction, epigenetic influences, and neuroinflammation with synaptic plasticity in neurodegenerative diseases. The following chapters review the dynamic changes that occur at the cellular and synaptic levels in Parkinson''s disease, Alzheimer''s disease, and Huntington''s disease, paving the way for innovative therapeutic strategies. Furthermore, the book presents various computational tools and methodologies essential for enhancing our understanding of synaptic plasticity. It examines the transformative role of artificial intelligence tools in addressing synaptic impairment across various neurodegenerative diseases.

Discusses the role of synaptic plasticity in neurodegenerative diseases, shedding light on how dynamic changes occur at the cellular and synaptic levels Explores the transformative role of artificial intelligence tools in addressing synaptic impairment across various neurodegenerative diseases Provides a comprehensive overview of neurodegenerative disorders, including pathogenesis, etiology, and treatment strategies Presents tools and techniques used to simulate the complex system biology of synaptic plasticity Examines the role of computational neuroscience in understanding and potentially treating conditions such as multiple sclerosis and amyotrophic lateral sclerosis

Toward the end, the book explores the role of synaptic impairment and computational neuroscience in understanding and potentially treating conditions such as multiple sclerosis and amyotrophic lateral sclerosis. With its multifaceted approach, this book serves as a useful resource for researchers, clinicians, and students in the fields of neuroscience, computational biology, and neurology.

This book explores the pivotal role of synaptic plasticity in the pathogenesis, progression, and potential treatment of neurodegenerative disorders. The initial chapter provides an in-depth understanding of the complexity and impact of neurodegenerative conditions. It discusses the association of mitochondrial dysfunction, epigenetic influences, and neuroinflammation with synaptic plasticity in neurodegenerative diseases. The following chapters review the dynamic changes that occur at the cellular and synaptic levels in Parkinson''s disease, Alzheimer''s disease, and Huntington''s disease, paving the way for innovative therapeutic strategies. Furthermore, the book presents various computational tools and methodologies essential for enhancing our understanding of synaptic plasticity. It examines the transformative role of artificial intelligence tools in addressing synaptic impairment across various neurodegenerative diseases.

Discusses the role of synaptic plasticity in neurodegenerative diseases, shedding light on how dynamic changes occur at the cellular and synaptic levels Explores the transformative role of artificial intelligence tools in addressing synaptic impairment across various neurodegenerative diseases Provides a comprehensive overview of neurodegenerative disorders, including pathogenesis, etiology, and treatment strategies Presents tools and techniques used to simulate the complex system biology of synaptic plasticity Examines the role of computational neuroscience in understanding and potentially treating conditions such as multiple sclerosis and amyotrophic lateral sclerosis

Toward the end, the book explores the role of synaptic impairment and computational neuroscience in understanding and potentially treating conditions such as multiple sclerosis and amyotrophic lateral sclerosis. With its multifaceted approach, this book serves as a useful resource for researchers, clinicians, and students in the fields of neuroscience, computational biology, and neurology.

This book delves into the complexities of brain health, aging, and neurodegeneration, exploring the varied roles that genetic, environmental, and lifestyle factors play in shaping brain health. It examines their contributions to the development and progression of neurodegenerative diseases. The opening chapters introduce the concept of the blood-brain barrier and its crucial role in maintaining brain health. It also discusses how this barrier is compromised with aging and in various neurodegenerative diseases, underscoring its importance in understanding disease progression. The book reviews specific conditions, including Alzheimer's disease and Parkinson's disease, analyzes their underlying mechanisms, and presents a range of pharmacological and nonpharmacological treatments, along with emerging therapies that offer hope for the future. It also explores other neurodegenerative diseases, such as ALS, Huntington's disease, and multiple sclerosis, detailing the unique pathways that lead to neurodegeneration and the latest approaches to treatment. The chapters provide insights into brain biomarkers and diagnostic techniques that help with early detection and diagnosis of neurodegenerative conditions. Toward the end, the book discusses the challenges faced by patients and caregivers and offers strategies for support and coping. This book serves as an essential resource for neuroscientists and neurologists.

This book delves into the complexities of brain health, aging, and neurodegeneration, exploring the varied roles that genetic, environmental, and lifestyle factors play in shaping brain health. It examines their contributions to the development and progression of neurodegenerative diseases. The opening chapters introduce the concept of the blood-brain barrier and its crucial role in maintaining brain health. It also discusses how this barrier is compromised with aging and in various neurodegenerative diseases, underscoring its importance in understanding disease progression. The book reviews specific conditions, including Alzheimer's disease and Parkinson's disease, analyzes their underlying mechanisms, and presents a range of pharmacological and nonpharmacological treatments, along with emerging therapies that offer hope for the future. It also explores other neurodegenerative diseases, such as ALS, Huntington's disease, and multiple sclerosis, detailing the unique pathways that lead to neurodegeneration and the latest approaches to treatment. The chapters provide insights into brain biomarkers and diagnostic techniques that help with early detection and diagnosis of neurodegenerative conditions. Toward the end, the book discusses the challenges faced by patients and caregivers and offers strategies for support and coping. This book serves as an essential resource for neuroscientists and neurologists.

Endophytes have unique characteristics to propagate inside host plants and aide the host by providing additional defense against environmental stresses and phytopathogens. Among endophytes, endophytic fungi have been recognized as a proliferating source for the production of bioactive compounds with potential in both the agricultural and health industries.Excessive use of pesticides in agriculture as well as in the food supply chain have led to increased antimicrobial resistance (AMR), which is one of the more serious global health concerns. Endophytic fungi and their associated bioactive substances have been reported to show natural ability to fight against pathogens and can reduce the development of AMR in nature. Studies also reported their potential as producers of hormones that enhance plant growth and several compounds having biological activities without any adverse effects.This book covers the pharmaceutical potential offungal endophytes as elucidated through advanced bioinformatics tools and modern techniques. Also synthetic drugs are losing their efficacy to treat microbial-induced disease due to this emergence of drug-resistant microbes. Therefore, insight into the detection of valuable plant constituents is a pressing priority in order to achieve effective pharmaceutical treatments. This book provides lucid discussion of the most recent research and provides knowledge about the applications of endophytic fungi with a specific focus to their pharmaceutical potential.

Endophytes have unique characteristics to propagate inside host plants and aide the host by providing additional defense against environmental stresses and phytopathogens. Among endophytes, endophytic fungi have been recognized as a proliferating source for the production of bioactive compounds with potential in both the agricultural and health industries.Excessive use of pesticides in agriculture as well as in the food supply chain have led to increased antimicrobial resistance (AMR), which is one of the more serious global health concerns. Endophytic fungi and their associated bioactive substances have been reported to show natural ability to fight against pathogens and can reduce the development of AMR in nature. Studies also reported their potential as producers of hormones that enhance plant growth and several compounds having biological activities without any adverse effects.This book covers the pharmaceutical potential offungal endophytes as elucidated through advanced bioinformatics tools and modern techniques. Also synthetic drugs are losing their efficacy to treat microbial-induced disease due to this emergence of drug-resistant microbes. Therefore, insight into the detection of valuable plant constituents is a pressing priority in order to achieve effective pharmaceutical treatments. This book provides lucid discussion of the most recent research and provides knowledge about the applications of endophytic fungi with a specific focus to their pharmaceutical potential.

Endophytes have unique characteristics to propagate inside host plants and aide the host by providing additional defense against environmental stresses and phytopathogens. Among endophytes, endophytic fungi have been recognized as a proliferating source for the production of bioactive compounds with potential in both the agricultural and health industries.Excessive use of pesticides in agriculture as well as in the food supply chain have led to increased antimicrobial resistance (AMR), which is one of the more serious global health concerns. Endophytic fungi and their associated bioactive substances have been reported to show natural ability to fight against pathogens and can reduce the development of AMR in nature. Studies also reported their potential as producers of hormones that enhance plant growth and several compounds having biological activities without any adverse effects.This book covers the pharmaceutical potential offungal endophytes as elucidated through advanced bioinformatics tools and modern techniques. Also synthetic drugs are losing their efficacy to treat microbial-induced disease due to this emergence of drug-resistant microbes. Therefore, insight into the detection of valuable plant constituents is a pressing priority in order to achieve effective pharmaceutical treatments. This book provides lucid discussion of the most recent research and provides knowledge about the applications of endophytic fungi with a specific focus to their pharmaceutical potential.

This book provides an in-depth exploration of microbiota profiling and precision medicine, including the underlying mechanisms, delivery methods, treatment strategies, and the impact of biomarker-targeted drug delivery. It incorporates the latest research findings, such as biomarker-targeted drug delivery, clinical assessment and diagnosis, and therapeutic approaches. The book offers a comprehensive overview of the latest developments in biomarker-targeted drug delivery strategies. It addresses the challenges faced by healthcare professionals, offering actionable strategies for effective multidisciplinary care, along with patient and family perspectives, coping mechanisms, and ways to improve quality of life. By combining scientific knowledge, clinical expertise, and patient insights, the book enhances understanding, diagnosis, and treatment options for these complex conditions. These qualities distinguish it from existing publications and make it a valuable resource for readers seeking a thorough and engaging overview of this subject.The chapters cover a broad range of topics, including recent advances in microbiota profiling techniques, microbiota's role in drug metabolism and toxicity, and its immunomodulatory effects. Special focus is given to the involvement of microbiota in neurodegenerative diseases such as Alzheimer's and Parkinson's, emphasizing the therapeutic potential of microbiome-targeted strategies. The authors provide expert analysis on integrating microbiota-derived data with innovative tools like nanotechnology and machine learning to improve drug delivery systems. Readers will also gain practical insights from case studies on microbiota-informed therapies for cancer, autoimmune conditions, and gastrointestinal disorders. This book is essential for researchers, clinicians, academicians, and students working in microbiome science, pharmacology, biotechnology, and precision medicine. It addresses key questions such as biomarker validation, data integration, and the ethical considerations necessary for the clinical use of microbiome-based therapies.

This book provides an in-depth exploration of microbiota profiling and precision medicine, including the underlying mechanisms, delivery methods, treatment strategies, and the impact of biomarker-targeted drug delivery. It incorporates the latest research findings, such as biomarker-targeted drug delivery, clinical assessment and diagnosis, and therapeutic approaches. The book offers a comprehensive overview of the latest developments in biomarker-targeted drug delivery strategies. It addresses the challenges faced by healthcare professionals, offering actionable strategies for effective multidisciplinary care, along with patient and family perspectives, coping mechanisms, and ways to improve quality of life. By combining scientific knowledge, clinical expertise, and patient insights, the book enhances understanding, diagnosis, and treatment options for these complex conditions. These qualities distinguish it from existing publications and make it a valuable resource for readers seeking a thorough and engaging overview of this subject.The chapters cover a broad range of topics, including recent advances in microbiota profiling techniques, microbiota's role in drug metabolism and toxicity, and its immunomodulatory effects. Special focus is given to the involvement of microbiota in neurodegenerative diseases such as Alzheimer's and Parkinson's, emphasizing the therapeutic potential of microbiome-targeted strategies. The authors provide expert analysis on integrating microbiota-derived data with innovative tools like nanotechnology and machine learning to improve drug delivery systems. Readers will also gain practical insights from case studies on microbiota-informed therapies for cancer, autoimmune conditions, and gastrointestinal disorders. This book is essential for researchers, clinicians, academicians, and students working in microbiome science, pharmacology, biotechnology, and precision medicine. It addresses key questions such as biomarker validation, data integration, and the ethical considerations necessary for the clinical use of microbiome-based therapies.