Thomas J. Webster – författare

Biomaterials in Translational Medicine delivers timely and detailed information on the latest advances in biomaterials and their role and impact in translational medicine. Key topics addressed include the properties and functions of these materials and how they might be applied for clinical diagnosis and treatment. Particular emphasis is placed on basic fundamentals, biomaterial formulations, design principles, fabrication techniques and transitioning bench-to-bed clinical applications. The book is an essential reference resource for researchers, clinicians, materials scientists, engineers and anyone involved in the future development of innovative biomaterials that drive advancement in translational medicine.

Nanomedicine: Technologies and Applications, Second Edition provides an important review of this exciting technology and its growing range of applications. In this new edition, all chapters are thoroughly updated and revised, with new content on antibacterial technologies and green nanomedicine. Sections introduce the material, cover their properties, review nanomedicine for therapeutics, imaging and soft tissue engineering, including organ regeneration, skin grafts, nanotubes and self-assembled nanomaterials. Other sections cover bone and cartilage tissue engineering, nanostructured particles for antibacterial purposes, advances in green nanomedicine, and using natural nanomedicine to fight disease.

This book is an indispensable guide for all those involved in the research, development and application of this exciting technology, whilst also providing a comprehensive introduction for students and academics interested in this field.

Emerging Nanomaterials and Nano-based Drug Delivery Approaches to Combat Antimicrobial Resistance focuses on recent and emerging trends surrounding nanomaterials and nano-drug delivery approaches to combat antimicrobial resistance. The relationship between nanomaterials and antimicrobial activity needs to be deeply explored to meet the challenges of combating� antimicrobial resistance. The content of this book is divided into three main topic areas, including (i) how to overcome the existing traditional approaches to combat antimicrobial resistance, (ii) applying multiple drug delivery mechanisms to target multi-drug resistant microbes, and (iii) how nanomaterials can be used as drug carriers.

This is an important reference source for those looking to understand how nanotechnology plays an important role in combatting disease and infection. As antimicrobial resistance threatens the effective prevention and treatment of an ever-increasing range of infections caused by bacteria, parasites, viruses, and fungi, this is a timely resource.

In spite of the potential use of nanomaterials as tissue engineering devices, implants, biosensors, drug delivery devices, etc., there has yet to be a compilation of the risks associated with the in vivo use of nanomaterials. There are numerous and well-known risks because of the size of nanoparticles. For example, nanoparticles can cross cell membranes and enter the cytoplasm undetected.

The aim of this book is to provide one of the first (if not the first) detailed views of how cells and tissues in the body deal with nanoparticles. This is important not only for implantable devices, but also for the manufacturing of nanophase materials when particles can be inhaled or enter the body through the skin. Only by compiling research at the intersection of nanoparticles and biological processes can we determine if nanophase materials are safe to be manufactured, handled, and/or implanted for various medical applications.

Medical Nanobiotechnology: Nanomedicine for Repair, Regeneration, Remodelling, and Recovery thoroughly reviews the potential of functionalized biomaterials as ideal candidates for nanomedicine. This book covers advances in the development of nanotheranostic agents that can simultaneously help in both effective therapy and rapid diagnosis. A range of materials is covered, including their fabrication, characterization, and assessment, as well as their functionalization and incorporation into implants and medical devices. Clinical aspects and challenges are discussed, helping bridge the gap between laboratory research and the translational impact as nanomedicine begins to develop point-of-care customized therapy. This book is an interdisciplinary reference for researchers and R&D groups interested in the development of novel nanobiomaterials for therapeutic applications.

Immunomodulatory Biomaterials and Nano-immunotherapies reviews the general cellular and biochemical barriers of the tumor microenvironment and other immune diseases, the ways they are addressed by modern immunotherapies, and the specific barriers facing particular immunotherapeutic approaches. The latest research on immunomodulatory biomaterials is examined, providing a perspective on their future opportunities in modulating disease treatment strategies. Translational considerations and lessons learned from the various components of nanotechnology-enabled immunotherapies, including conventional immunotherapies,?nucleic acids, nanotechnology, and biotechnology-based therapeutics are assessed. Finally, a framework for the development of the next generation of nanotechnology-enabled immunotherapies is detailed, providing guidance and suggestions for those interested in the development of novel immunomodulatory nanobiomaterials. Immunomodulatory Biomaterials and Nano-immunotherapies is a key reference for researchers and developers working in biomaterials, nanotechnology, immunology, biomedical engineering and pharmaceutical sciences.