Wael Mohamed – författare

Handbook of Neurodegenerative Disorders: Mechanism, Diagnostic and Therapeutic Advances provides a comprehensive review on the current biomedical studies aimed at identifying the underlying causes of neurodegeneration. This book reviews the most recent developments in molecular and cellular processes altered during neurodegeneration. Divided into four parts, the first covers the mechanism of cell death in neurodegeneration. The second section reviews the recent progress in gene and gene products in neurodegeneration, including Huntington's disease, Parkinson's disease, Friedreich' s ataxia, and spinal muscular atrophy. The final sections cover the current and future diagnostic techniques of neurodegenerative disorders along with therapeutic approaches.Reviews big data and neurodegeneration disorders, including gene mappingExamines the structural basis of protein assembly into amyloid filaments in neurodegenerative diseaseCovers the progress and challenges of pharmacotherapy of neurodegenerative disorders

Translational Models of Parkinson's Disease and Related Movement Disorders focuses on cutting-edge techniques for creating and validating current Parkinson's Disease translational experimental models. Various characteristics of these models are examined, including the prion-like properties of -synuclein, mitochondrial functions connected to the PINK1-Parkin pathway/CHCHD2, the endolysosome pathway connected to LRRK2, VPS35, and ATP13A2 using cultured cells (including patient iPS cells). This book also highlights the future possibilities of introducing new models for Parkinson's Disease and related movements disorders, underscoring current advancements, pre-clinical and clinical developments, and future scope related to numerous models.

Highlights induction and validation of different available experimental models of Parkinson's DiseaseProvides a comparative prospect of different experimental models of Parkinson's DiseaseDiscusses the advantages and disadvantages of each model, including associated limitations

Pharmacotherapy of Parkinson's Disease: from Basics to Practice provides a comprehensive guide on the pharmacological treatment of Parkinson's Disease, offering students and clinicians a combination of foundational knowledge and advanced clinical insights. The book bridges theoretical concepts with real-world clinical scenarios and equips readers with the tools necessary to effectively manage Parkinson's Disease in practice. Offering a detailed review of symptoms, treatment gaps, and emerging therapies, this book delves into the pathogenesis the disease, along with dopaminergic treatments and management of motor and non-motor symptoms.Providing updates on emerging therapies, including innovative treatment approaches, this book serves as a valuable reference for continuous learning and staying current with evolving practices and research in Parkinson's Disease management.Reviews current pharmacological treatments for Parkinson's Disease, from foundational principles to advanced applicationsOutlines the latest treatment protocols, therapeutic strategies, and emerging trends in Parkinson’s Disease pharmacotherapyProvides detailed insights into how different drugs operate at the molecular and cellular levels, enhancing comprehension of PD pathophysiology and drug mechanismsPresents case studies, clinical trial outcomes, and real-world applications, detailing practical insights applicable to both research and clinical practice

The COVID-19 pandemic forced the world to pause and reevaluate how we operate specifically in medicine, shifting to telemedicine and telehealth. Integrating telemedicine and telehealth into the healthcare system enables patient safety and has been proven beneficial to medical and surgical practices including patient primary care. Telehealth in Movement Disorder: Principles, Strategies, Applications, and New Directions provides guidance on how to deliver clinical assessment and treatment to movements disorders patients through telemedicine. This book is divided into three distinct sections. The first section reviews general principles including strategies, standards, policies, and ethical aspects. The second section explores how telemedicine can be integrated into diagnosis, treatment, and care of patients with movement disorders including the use of new AI technologies. The final section discusses the integration and application of telemedicine in developing countries, including challenges and future opportunities.Reviews how to create a compliance and evidence-based telehealth practiceDiscusses the advantages and disadvantages of telemedicine and telepsychiatry for movements disordersOutlines new technologies Inertial measurement unit (IMU), Smart Textile and wearable healthcare

Advanced and Integrative Therapeutic Strategies in Parkinson’s Disease Management offers a comprehensive exploration of the latest innovations and multidisciplinary approaches in Parkinson’s Disease treatment. The volume is organized into sections covering genetic therapies, gut microbiota, artificial intelligence, virtual reality, neuroprotective strategies, polypharmacy, and combination therapies. It addresses the integration of personalized medicine, neuroprotective diets, natural products, cognitive enhancers, and ethical considerations. Additional chapters introduce traditional medicine, music therapy, and the synergy between pharmacotherapy and complementary modalities. The book equips readers with the knowledge to implement innovative therapies, navigate complex ethical landscapes, and integrate multidisciplinary and complementary approaches.This reference is essential for those seeking to advance clinical practice and research in Parkinson’s Disease through the adoption of cutting-edge strategies.Highlights advanced and integrative therapeutic strategies for Parkinson’s Disease managementExamines multidisciplinary and complementary approaches to careAddresses ethical and practical challenges of novel translational therapiesDiscusses future directions for personalized care

Due to the lack of secure, efficient, and patient-friendly therapies for neurodegenerative disorders, there is a rising demand for innovative approaches. Despite the limited number of nanocarriers approved for human use, they have demonstrated significant potential in preclinical and, in some instances, clinical trials. In alignment with this objective, the chapters of the book are structured to offer a comprehensive overview of recent advancements in medication and dosage form development, specifically emphasizing the nanoparticulate system for targeting the brain. This book aims to furnish readers with a thorough understanding of the clinical application of nanocarrier systems for treating neurodegenerative disorders, encompassing the latest developments, challenges, safety concerns, toxicity issues, regulatory considerations, prospects, and limitations. Individuals in academia, the scientific community, business, and education seeking a more effective approach to target the brain will find valuable insights in this resource.Key FeaturesProvides a comparative perspective of various nanocarrier systems, therefore facilitating the researcher's selection of appropriate nanoparticulate carriersHighlights the related restrictions of brain delivery and current available medicinesIncludes information on the advantages and disadvantages of various biomaterials utilized in the development of nanocarriers for brain targetingEmphasizes distinct facets of surface functionalization according to the brain area of interestPresents the current advances, preclinical and clinical development, and the future potential of multiple brain-targeting technologies

The increasing demand for innovative techniques arises from the lack of safe, effective, and patient-friendly therapies for neurodegenerative disorders. With this objective in mind, the chapters of the book are structured to offer a thorough insight into recent advancements in utilizing the zebrafish (ZF) as a model for studying Parkinson’s disease (PD). This book aims to present readers with a comprehensive understanding of the clinical application of the ZF model in treating PD, encompassing the latest developments, challenges, safety considerations, toxicity issues, regulatory aspects, future potential, and limitations. Individuals in academia, the scientific community, business, and education seeking a more effective approach to target the brain stand to benefit from this resource.Key FeaturesProvides a comparative perspective of the zebrafish–Parkinson’s disease modelHighlights the restrictions of available medicinesDescribes biochemical and histopathological characteristics, advantages, and disadvantages of this modelEmphasizes distinct facets of histopathologyPresents advances and developments of the future potential perspectives

This book comprehensively reviews the relationship between micronutrients and brain in health and diseases. The book also explores the relationship between micronutrients and brain disorders including depression, epilepsy, PD, and Autism.

This book comprehensively reviews the relationship between micronutrients and brain in health and diseases. The book also explores the relationship between micronutrients and brain disorders including depression, epilepsy, PD, and Autism.

The book comprehensively reviews the role of nutrition in psychiatric disorders. The book further explores the recent advancements in understanding the important role of nutrients as therapeutics in various psychiatric disorders.

The book comprehensively reviews the role of nutrition in psychiatric disorders. It provides mechanistic insights into the effects of nutrition on metabolic pathways, mitochondrial nutrients, neurodegeneration and CNS disorders, cell signaling, and neuronal functions.  The book further highlights the role of diet in preventing and treating mental health and modifying drug treatment effects. Further, it explores the relationship between nutrition and psychiatric disorders, including depression, autism, anxiety, Attention-Deficit / Hyperactivity Disorder, and OCD. The book further explores the recent advancements in understanding the important role of nutrients as therapeutics in various psychiatric disorders. Lastly, it presents an overview of nutrients as neuroprotective agents along with the main principles of nutrigenomics. The book is essential reading for neuroscientists interested interest in food therapeutic strategies.

This book explores the molecular mechanisms of iron hemostasis in the brain and discusses the cognitive and behavioral implications of iron deficiency. It discusses the role of iron deficiency in sleep disorders and offers diagnosis and treatment of iron-related CNS diseases.

This book explores the molecular mechanisms of iron hemostasis in the brain and discusses the cognitive and behavioral implications of iron deficiency. It discusses the role of iron deficiency in sleep disorders and offers diagnosis and treatment of iron-related CNS diseases.

Offering a culturally inclusive and integrative approach, the book bridges functional foods, personalized nutrition, and mental wellness, providing groundbreaking insights into complex issues such as substance use disorders and chronic pain.

The book explores the intricate relationship between nutrition, brain function, and psychiatric disorders. In the final section, the book delves into the nutritional treatment of psychiatric disorders, including the psychopharmacology of psychiatric disorders and food intake, and multidisciplinary approaches to psychiatric treatment..

The book provides a thorough examination of the crucial connection between diet, cognitive aging, and dementia using a multidisciplinary approach.

The book provides a thorough examination of the crucial connection between diet, cognitive aging, and dementia using a multidisciplinary approach. It dives into the complex area of neurology, illuminating different forms of dementia, their underlying pathophysiology, and the risk factors related to them. It explains the symptoms, diagnoses, and therapies for dementia. The book explores the effects of dietary elements like protein, micronutrients, and superfoods, demonstrating their potential to protect cognitive function. Additionally, it discusses how critical vitamins like D and B12, natural antioxidants, and trace minerals affect dementia risk and development. The book explains the use of conventional herbal medicine as a supplementary strategy to dementia therapy, evaluating its potential efficacy and safety. The book provides evidence-based advice to professionals, physicians, researchers, nutritionists, and healthcare professionals to understand the nutritional requirements to control dementia.

The book provides a comprehensive exploration of the relationship between nutrition and traumatic brain injury (TBI). Divided into two sections, the book covers various aspects of TBI, from its biomechanics and pathophysiological changes to evidence-based clinical guidelines and experimental models.Section I covers the background of TBI, including the definition and biomechanics of TBI, an understanding of pathophysiological changes that occur in the brain, and the importance of evidence-based clinical guidelines for effective TBI management. The section also delves into experimental models of TBI and the role of biomarkers in diagnosing and assessing TBI. Furthermore, it explores early feeding guidelines following TBI, emphasizing the significance of nutrition in the recovery process.Section II focuses on the connection between nutrition and TBI. It examines the concept of resilience and nutri-protection against TBI prior to the injury, highlighting strategies to enhance the brain's ability to withstand trauma. The book then explores the role of various nutrients and dietary components in TBI, such as antioxidants, branched-chain amino acids, choline, creatine, ketogenic diet, magnesium, polyunsaturated fatty acids (EPA and DHA), polyphenols, vitamin D, and zinc. Each topic is explored in depth, considering their impact on TBI outcomes and potential therapeutic applications.Furthermore, this section delves into nutritional interventions for TBI management. It addresses the selection of appropriate nutritional interventions and mechanistic targets for effective treatment. The section also explores the integration of nutrition into clinical practice guidelines for TBI and the emerging field of nutrigenomics, which investigates the interaction between nutrition and the genetic factors involved in TBI. Additionally, the section discusses the role of pharmacognosy in TBI research and provides nutritional recommendations for TBI management, considering the diverse needs of individuals affected by TBI.The book contributes to advancing the understanding and management of TBI by exploring the background, highlighting the importance of nutrition, and offering insights into nutritional interventions with potential implications for both preventive and therapeutic approaches.The book is a great resource for students and brain/neuroscience researchers.

The book provides a comprehensive exploration of the relationship between nutrition and traumatic brain injury (TBI). Divided into two sections, the book covers various aspects of TBI, from its biomechanics and pathophysiological changes to evidence-based clinical guidelines and experimental models.Section I covers the background of TBI, including the definition and biomechanics of TBI, an understanding of pathophysiological changes that occur in the brain, and the importance of evidence-based clinical guidelines for effective TBI management. The section also delves into experimental models of TBI and the role of biomarkers in diagnosing and assessing TBI. Furthermore, it explores early feeding guidelines following TBI, emphasizing the significance of nutrition in the recovery process.Section II focuses on the connection between nutrition and TBI. It examines the concept of resilience and nutri-protection against TBI prior to the injury, highlighting strategies to enhance the brain's ability to withstand trauma. The book then explores the role of various nutrients and dietary components in TBI, such as antioxidants, branched-chain amino acids, choline, creatine, ketogenic diet, magnesium, polyunsaturated fatty acids (EPA and DHA), polyphenols, vitamin D, and zinc. Each topic is explored in depth, considering their impact on TBI outcomes and potential therapeutic applications.Furthermore, this section delves into nutritional interventions for TBI management. It addresses the selection of appropriate nutritional interventions and mechanistic targets for effective treatment. The section also explores the integration of nutrition into clinical practice guidelines for TBI and the emerging field of nutrigenomics, which investigates the interaction between nutrition and the genetic factors involved in TBI. Additionally, the section discusses the role of pharmacognosy in TBI research and provides nutritional recommendations for TBI management, considering the diverse needs of individuals affected by TBI.The book contributes to advancing the understanding and management of TBI by exploring the background, highlighting the importance of nutrition, and offering insights into nutritional interventions with potential implications for both preventive and therapeutic approaches.The book is a great resource for students and brain/neuroscience researchers.

This book provides a thorough examination of the correlation between nutrition and stroke. Additionally, it investigates how various types of nutrition relate to stroke. Moreover, it discusses recent progress in recognizing the significant therapeutic role of different nutrients in addressing stroke.

This book reviews the role of trace elements in brain development, function, metabolism, and neurodegenerative disorders. It explores the molecular mechanisms of the effects of trace elements on  metabolic pathways, mitochondrial nutrients, neurodegeneration, Central Nervous System (CNS) disorders, cell signaling, and neuronal functions. The book also discusses transport mechanisms of trace elements within CNS and their impact on neurotransmitter biology. Further, it examines the deleterious effects due to dyshomeostasis of trace elements in the central nervous system (CNS), resulting in damage to neurons and glial cells through the generation of reactive oxygen species and oxidative stress turn leading to neurodegeneration and neurological dysfunction. The book also explores the putative role of trace element deficiency in psychiatric disorders, including depression, and the imbalance of trace elements on neuronal genomic stability.