Prodrugs

From the reviews: "The editors provide a comprehensive overview on early and current prodrug strategies. ... medicinal chemists will highly appreciate this book. ... the book should be available in the libraries of every pharmaceutical and small-molecule biotech company." (Hugo Kubinyi, ChemMedChem, Issue 3, 2008)

• A Case for Prodrugs.- A Case for Prodrugs.- Problems Addressable by Prodrugs.- Prodrug Approaches to Enhancing the Oral Delivery of Poorly Permeable Drugs.- Topical Delivery Using Prodrugs.- Prodrug approaches to ophthalmic drug delivery.- Overcoming Poor Aqueous Solubility of Drugs for Oral Delivery.- Prodrugs and Parenteral Drug Delivery.- Poly (ethylene glycol) Prodrugs: Altered Pharmacokinetics and Pharmacodynamics.- Prodrugs to Reduce Presystemic Metabolism.- Controlled Release — Small Molecules.- Controlled Release - Macromolecular Prodrugs.- Controlled Release - Proenzymes.- Targeting - Theoretical and Computational Models.- Targeting - Cancer — Small Molecules.- Monoclonal Antibody Drug Conjugates for Cancer Therapy.- Antibody-Directed Enzyme Prodrug Therapy.- Prodrugs for Liver-targeted Drug Delivery.- Prodrug Approaches for Drug Delivery to the Brain.- Lymphatic Absorption of Orally Administered Prodrugs.- Colonic Delivery.- Functional Group Approach to Prodrugs.- Prodrugs of Carboxylic Acids.- Prodrugs of Alcohols and Phenols.- Prodrugs of Amines.- Prodrugs of Amides, Imides and Other NH-acidic Compounds.- Prodrugs of Benzamidines.- Prodrugs of Phosphonates, Phosphinates, and Phosphates.- Functional Group Approaches to Prodrugs: Functional Groups in Peptides.- Macromolecular Prodrugs of Small Molecules.- Miscellaneous Functional Groups.- Prodrugs — Preclinical and Clinical Considerations.- Prodrugs: Absorption, Distribution, Metabolism, Excretion (ADME) Issues.- Formulation Challenges of Prodrugs.- Safety Assessment of Prodrugs.- Toxicological Issues with Pivalate Prodrugs.- Case Studies.- Case Study: Adefovir Dipivoxil: An Oral Prodrug of Adefovir.- Case Study: Amifostine: (Ethyol®).- Case Study: Capecitabine: A Prodrug of 5-Fluorouracil.- Case Study:Cefditoren Pivoxil: An Oral Prodrug of Cefditoren.- Case Study: Cefuroxime Axetil: An Oral Prodrug of Cefuroxime.- Case Study: Clindamycin 2-Phosphate, A Prodrug of Clindamycin.- Case Study: Enalapril: A Prodrug of Enalaprilat.- Case Study: Famciclovir: A Prodrug of Penciclovir.- Case Study: Fosamprenavir: A Prodrug of Amprenavir.- Case Study: Fosinopril.- Case Study: Fosphenytoin: A Prodrug of Phenytoin.- Case Study: Irinotecan (CPT-11), A Water-soluble Prodrug of SN-38.- Case Study: Latanoprost: Isopropylester of a Prostaglandin F2? Analog.- Case Study: Moexipril Hydrochloride: A Prodrug of Moexiprilat.- Case Study: Mycophenolate Mofetil.- Case Study: Olmesartan Medoxomil: A Prodrug of Olmesartan.- Case Study: Omeprazole (Prilosec®).- Case Study: Oseltamivir: An Orally Bioavailable Ester Prodrug of Oseltamivir Carboxylate.- Case Study: Parecoxib: A Prodrug of Valdecoxib.- Case Study: Tenofovir Disoproxil Fumarate: An Oral Prodrug of Tenofovir.- Case Study: Travoprost: A Potent PGF2? Analog.- Case Study: Valacyclovir: A Prodrug of Acyclovir.- Case Study: Valganciclovir: A Prodrug of Ganciclovir.- Case Study: Vantin: A Prodrug of Cefpodoxime.- Case Study: Ximelagatran: A Double Prodrug of Melagatran.