Biotechnology: Pharmaceutical Aspects – serie
Visar alla böcker i serien Biotechnology: Pharmaceutical Aspects. Handla med fri frakt och snabb leverans.
20 produkter
Optimizing the "Drug-Like" Properties of Leads in Drug Discovery
Av Ronald Borchardt, Edward Kerns m. fl.
Inbunden, 2006
2247 kr
Lägg i varukorg
Drug discovery and development is a very complex, costly, and ti- consuming process. Because of the uncertainties associated with predicting the pharmacological effects and the toxicity characteristics of new chemical entities in man, their clinical development is quite prone to failure. In recent …
Prodrugs
Challenges and Rewards
Av Valentino Stella, Ronald Borchardt m. fl.
2007
6611 kr
Lägg i varukorg
Prodrugs are substances administered in an inactive form that is then metabolized in the body in vivo into the active compound. The rationale behind administering prodrugs is to optimize absorption, distribution, metabolism, and excretion of these drugs. Since first described in the 1950s, prodrugs …
Solvent Systems and Their Selection in Pharmaceutics and Biopharmaceutics
Av Patrick Augustijns, Marcus Brewster
Inbunden, 2007
2399 kr
Lägg i varukorg
Solvent systems are integral to drug development and pharmaceutical technology. This single topic encompasses numerous allied subjects running the gamut from recrystallization solvents to biorelevant media. The goal of this contribution to the AAPS Biotechnology: Pharmaceutical Aspects series is to …
Drug Absorption Studies
In Situ, In Vitro and In Silico Models
Av Carsten Ehrhardt, Kwang-Jin Kim
Inbunden, 2008
2247 kr
Lägg i varukorg
In the last 15 years, a great number of cell- or tissue-based in vitro models have been introduced into the biopharmaceutics arena. These models mimic the different biological barriers that a drug has to overcome to finally reach its target organ/cell/receptor. These in vitro models have been found …
Immunogenicity of Biopharmaceuticals
Av Marco Weert, Eva Horn Møller
Inbunden, 2008
1638 kr
Lägg i varukorg
A particular issue for biopharmaceuticals that has not been addressed comprehensively in any book, is the potential of an immune response to the biopharmaceutical product. That is, the human body marks the drug as a foreign body, and develops antibodies against the drug. These antibodies may be …
Current Trends in Monoclonal Antibody Development and Manufacturing
Av S. Shire, Steven J. Shire m. fl.
Inbunden, 2009
2247 kr
Lägg i varukorg
Monoclonal antibodies represent one of the fastest growing areas of new drug development within the pharmaceutical industry. Several blockbuster products have been approved over the past several years including Rituxan, Remicade, Avastin, Humira, and Herceptin. In addition, over 300 new drugs are …
Advances in Bioactivation Research
Inbunden, 2008
2247 kr
Lägg i varukorg
I have always been interested in chemistry and biology. My undergraduate, graduate, and postdoctoral trainings in pharmacy, medicinal chemistry and pharmacology, respectively, have strengthened this interest and led me to realize that significant advances in medicine have frequently been realized …
Nanotechnology in Drug Delivery
Av Melgardt M. de Villiers, Pornanong Aramwit m. fl.
Inbunden, 2008
2583 kr
Lägg i varukorg
The reader will be introduced to various aspects of the fundamentals of nanotechnology based drug delivery systems and the application of these systems for the delivery of small molecules, proteins, peptides, oligonucleotides and genes. How these systems overcome challenges offered by biological …
Methods for Structural Analysis of Protein Pharmaceuticals
Av Wim Jiskoot, Daan Crommelin
Inbunden, 2005
3371 kr
Lägg i varukorg
Protein pharmaceuticals form a fast-growing category in the arsenal of drugs. In the coming years, the patents on a number of the first-generation protein pharmaceuticals will expire, opening the door for the development of biogenerics into the market. However, it is very difficult to characterize …
Pharmaceutical Profiling in Drug Discovery for Lead Selection
Av Ronald Borchardt, Edward Kerns m. fl.
Inbunden, 2005
2471 kr
Lägg i varukorg
At a time when pharmaceutical companies have limited resources to develop newer and better drugs, they must continually evaluate the effectiveness and efficiency of their research and development process. This volume focuses on how to increase the efficiency of drug discovery and development. …
Pharmaceutical Stability Testing to Support Global Markets
Av Kim Huynh-Ba
Inbunden, 2009
1799 kr
Lägg i varukorg
The International Conference of Harmonization (ICH) has worked on har- nizing the stability regulations in the US, Europe, and Japan since the early 1990s. Even though the Stability Guidelines Q1A (R2) was issued over a decade ago, issues surrounding this arena continue to surface as the principles …
Solvent Systems and Their Selection in Pharmaceutics and Biopharmaceutics
Av Patrick Augustijns, Marcus Brewster
Häftad, 2010
2309 kr
Lägg i varukorg
Solvent systems are integral to drug development and pharmaceutical technology. This single topic encompasses numerous allied subjects running the gamut from recrystallization solvents to biorelevant media. The goal of this contribution to the AAPS Biotechnology: Pharmaceutical Aspects series is to …
Immunogenicity of Biopharmaceuticals
Av Marco Weert, Eva Horn Møller
Häftad, 2010
1687 kr
Lägg i varukorg
A particular issue for biopharmaceuticals that has not been addressed comprehensively in any book, is the potential of an immune response to the biopharmaceutical product. That is, the human body marks the drug as a foreign body, and develops antibodies against the drug. These antibodies may be …
Nanotechnology in Drug Delivery
Av Melgardt M. de Villiers, Pornanong Aramwit m. fl.
Häftad, 2010
2309 kr
Lägg i varukorg
The reader will be introduced to various aspects of the fundamentals of nanotechnology based drug delivery systems and the application of these systems for the delivery of small molecules, proteins, peptides, oligonucleotides and genes. How these systems overcome challenges offered by biological …
Current Trends in Monoclonal Antibody Development and Manufacturing
Av Steven J. Shire, Wayne Gombotz m. fl.
Häftad, 2012
2312 kr
Lägg i varukorg
Monoclonal antibodies represent one of the fastest growing areas of new drug development within the pharmaceutical industry. Several blockbuster products have been approved over the past several years including Rituxan, Remicade, Avastin, Humira, and Herceptin. In addition, over 300 new drugs are …
Pharmaceutical Stability Testing to Support Global Markets
Av Kim Huynh-Ba
Häftad, 2012
1801 kr
Lägg i varukorg
The International Conference of Harmonization (ICH) has worked on har- nizing the stability regulations in the US, Europe, and Japan since the early 1990s. Even though the Stability Guidelines Q1A (R2) was issued over a decade ago, issues surrounding this arena continue to surface as the principles …
Drug Absorption Studies
In Situ, In Vitro and In Silico Models
Av Carsten Ehrhardt, Kwang-Jin Kim
Häftad, 2016
2247 kr
Lägg i varukorg
In the last 15 years, a great number of cell- or tissue-based in vitro models have been introduced into the biopharmaceutics arena. These models mimic the different biological barriers that a drug has to overcome to finally reach its target organ/cell/receptor. These in vitro models have been found …
Advances in Bioactivation Research
Häftad, 2016
2247 kr
Lägg i varukorg
I have always been interested in chemistry and biology. My undergraduate, graduate, and postdoctoral trainings in pharmacy, medicinal chemistry and pharmacology, respectively, have strengthened this interest and led me to realize that significant advances in medicine have frequently been realized …
Optimizing the "Drug-Like" Properties of Leads in Drug Discovery
Av Ronald Borchardt, Edward Kerns m. fl.
Häftad, 2016
2247 kr
Lägg i varukorg
Drug discovery and development is a very complex, costly, and ti- consuming process. Because of the uncertainties associated with predicting the pharmacological effects and the toxicity characteristics of new chemical entities in man, their clinical development is quite prone to failure. In recent …
Prodrugs
Challenges and Rewards
Av Valentino Stella, Ronald Borchardt m. fl.
2017
4749 kr
Lägg i varukorg
Prodrugs are substances administered in an inactive form that is then metabolized in the body in vivo into the active compound. The rationale behind administering prodrugs is to optimize absorption, distribution, metabolism, and excretion of these drugs. Since first described in the 1950s, prodrugs …
