Neurological Disease and Therapy – serie

Duchenne Muscular Dystrophy (DMD) is one of the most prevalent genetic disorders of childhood and currently stands as an incurable condition. This authoritative guide provides a clear overview of the latest current and experimental approaches to the treatment of DMD and examines the clinical, genetic, and pathophysiological aspects of the disease in the context of emerging therapeutic modalities. The only available source on the subject, this reference emphasizes the importance of accurate diagnosis, carrier detection, and genetic counseling, and supplies state-of-the-art contributions on pharmacological interventions, regenerative medicine, and gene therapy.

With chapters by many of the foremost international authorities on aging, neurology, physical therapy, and rehabilitation, this reference provides an up-to-date review of approaches to gait disorders and falls. This volume presents the fundamental concepts of gait and describes the changes in mobility with aging and disease. A focus is placed on recent assessment and intervention practices for common gait disorders, especially those seen in older adults, including sections on neuro-psychological influences, fear of falling and exercise, and strategies for specific disease groups, such as patients with neurological disorders or those recovering from stroke or hip surgery.

Filling a gap in the literature, this reference offers 25 authoritative chapters on the epidemiology, clinical characteristics, and medical and surgical treatment of essential tremor and various tremor disorders, including chapters on Parkinsonian, cerebellar, neuropathic, post-traumatic, psychogenic, and drug-induced tremor. Reporting on the latest findings and research in the field, this guide discusses specific tremor disorders along with the various therapeutic regimens used to treat each of them. The authors supply up-to-date information on the etiology and pathogenesis of tumor, as well as state-of-the-art methods of identification and management of essential tremor and tremor disorders.

A reader friendly and quick reference guide for the identification, diagnosis, and treatment of sleep disorders, this resource covers the entire range of sleep medicine addressing only the most clinically relevant information for sleep disorders management. Each chapter presents a thoughtful course of action for diagnosis and treatment - detailing methods to obtain a sleep history, analyze physical exam findings, order blood work and testing, and apply the latest treatment modalities and follow-up regimens.

Standing at the forefront of neurogenetic medicine, this reference supplies the tools and information required by clinicians to become familiar with modern neurogenetic approaches and apply the data gleaned from these technologies to the diagnosis and treatment of neurogenetic disorders, as well as traditionally non-genetic conditions such as Parkinson's and Alzheimer's disease.

A thorough review of the surgical procedures and technologies currently available for the treatment of various movement disorders, this guide illustrates strategies for the management of conditions such as Parkinson's disease, essential tremor, dystonia, Tourette's syndrome, hemifacial spasm, and cerebral palsy-emphasizing surgical indications and outcomes, as well as methods of complication prevention and avoidance.

Supported by an extensive review of migraine pathogenesis and more than 200 case histories gleaned from the authors' personal experiences, this guide proposes two radical new concepts: all primary headaches are fundamentally a form of migraine and everyone may experience some manifestation of the migraine process in their life. Offering an in-depth overview of the migraine mechanism, including discussions of the neurogenic, vascular, platelet, and serotonin related components of the process, this source supplies extensive illustrations of the neuroanatomical structures involved in migraine and the latest insights from functional neuroimaging using BOLD fMRI and PET.

Spanning a wide array of topics relating to the diagnosis and treatment of cerebrovascular disease, this reference collects the latest studies and recommendations from a team of 75 leading authorities on the subject-including the management of subarachnoid hemorrhage, the treatment of acute ischemic stroke and aneurysms, and surgical interventions for carotid artery disease and intracranial vascular diseases.

Providing a detailed study of the anatomy, physiology, and pathology of peripheral nerves, this reference provides a clear approach to the evaluation, characterization, and treatment of peripheral neuropathies-reviewing each major class of these disorders with authoritative discussions of clinical characteristics, electrodiagnostic features, examination findings, and treatment options and outcomes.

A comprehensive review of current tactics in the therapeutic management of Parkinson's disease, this volume offers summaries of salient research findings as well as contemporary attitudes and practical advice from field specialists. The well-timed Third Edition is expanded and topically reorganized to register trends and progress in anti-parkinsonian medications, ablative surgical options, deep brain stimulation, nonmotor symptom treatments, nonmedical strategies, and investigational therapies.

This book is a comprehensive guide to the medical treatment of epilepsy and written for physicians in practice and those in training who take care of patients with seizures. It presents a review of every aspect of treatment that are considered prior to referring a patient for evaluation.

Emphasizing the clinical problems surrounding urogenital tract dysfunction, this up-to-date reference details the basic science, differential diagnosis, and treatment of a wide range of neurourological conditions.Covering recent advances in the neurobiology of the pelvic organs, the Handbook of Neuro-Urology reviews the neural control processes that govern pelvic organs discusses the pathogenic mechanisms behind neurological and smooth muscle disorders that produce bladder dysfunction describes the management of impaired bladder, bowel, and sexual function after brain damage and spinal cord injury examines various conditions that affect the autonomic nervous system and specifically result in bladder and sexual dysfunction investigates lower urinary tract function in the elderly suggests practical measures to manage urinary incontinence such as the use of pads, underpants, and appliances and more!

Inflammation of the brain, usually brought on by a viral infection, encephalitis currently poses a grave threat to patients around the world. With the migration of West Nile virus into North America, there is a greater awareness and corresponding need to understand, diagnose, and manage this illness. In Encephalitis: Diagnosis and Treatment, experts discuss advances in diagnostic tools, as well as therapeutic approaches that allow clinicians to better recognize and treat afflicted patients.Individual chapters address the principal infectious and non-infectious causes of brain inflammation, including paraneoplastic encephalitides—an apparent autoimmune process in patients with malignancies—as well as acute disseminated encephalomyelitis, a post-infectious disorder. The book addresses etiology, epidemiology, and specific issues in diagnosis, pathology, and treatment, including various laboratory methodologies, pathologic changes seen in the different disorders, and diagnosis and management of the seizures that occur quite frequently in these disorders. With contributions from a group of international experts, the book provides a perspective on this disorder that is both broad and in-depth.

Considered the largest breakthrough in the treatment of Parkinson’s disease in the past 40 years, Deep Brain Stimulation (DBS) is a pioneering procedure of neurology and functional neurosurgery, forging enormous change and growth within the field. The first comprehensive text devoted to this surgical therapy, Deep Brain Stimulation for Parkinson's Disease expertly examines all aspects of DBS from history and theory to patient evaluation, recovery, and rehabilitation. Features: Serves as an invaluable resource and teaching guide for patient evaluation and the selection of candidates for surgery Describes the surgical technique for DBS placement, reviewing both frame- and frameless-based approaches Considers the morbidity and mortality associated with the procedure and details strategies for complication avoidance Discusses pre- and post-operative management protocols, from the intensive care unit to rehabilitative settings Outlines medication adjustment in the post-DBS patient for enhanced patient recovery, including illustrative case examples Reviews the effects of DBS surgery on speech, balance, autonomic function, sleep, and weight Considers ethical and quality-of-life issues for DBS patients Edited by specialists in the top-tiers of the discipline, including contributors from the pioneering Movement Disorder Group at the University of Pennsylvania, this is an indispensable companion for the entire neurological and neurosurgical community.

Neurological Complications of Systematic Cancer and Antineoplastic Therapy provides an in-depth review of common manifestations related to neurology that occur in patients with systemic cancer. These include brain metastases, spinal cord compression, cerebrovascular events, and leptomeningeal disease. The book also discusses less common complications such as paraneoplastic disorders and neoplastic plexopathy.Highlights include: The pathophysiology and molecular biology of cancer and the metastatic phenotype Metastatic spread to cranial and peripheral nerves and brachial and lumbosacral plexuses Metabolic and nutritional disorders CNS infections Neurological complications of immunotherapy and bone marrow transplantsAdditional chapters review problems related to each specific tumor type, such as breast, lung, and colorectal, as well as gynecological cancer, genitourinary cancer, and malignant melanoma. The book also discusses neurological complications related to treatments such as radiation and chemotherapy. Bringing clinical trial knowledge from the bench to the bedside, this volume is an essential reference for the practicing oncologist and neurologist.

As the third leading cause of death in the United States, stroke accounts for one in every fifteen deaths and is the major cause of disability in the country. Compiled by a renowned editorial team, this reference bridges the gap between basic science and patient care protocols, and collects 43 expertly written chapters that range from laboratory-based research on animal models to the progression, mechanisms, treatment, and prognosis of diseases such as subarachnoid hemorrhage (SAH), intracerebral hemorrhage (ICH), focal ischemic stroke, and global cerebral ischemia.

The clinical management of patients with acute brain and spinal cord injury has evolved significantly with the advent of new diagnostic and therapeutic modalities. Acute Brain and Spinal Cord Injury presents the latest medical science and highlights controversies in the clinical management of patients with acute brain and spinal cord injuries.Divided into five sections—traumatic brain injury, ischemic stroke, intracerebral and subarachnoid hemorrhage, and spinal cord injury—this text: Delineates diagnostic and monitoring tools, pharmacotherapies, and interventional and surgical treatments Examines and explores recently published laboratory trials and research Incorporates over 50 diagrams and figures for concise communication of scientific information This stand-alone reference is a powerful tool in helping today’s neurologists and neurosurgeons keep abreast of current advancements in brain and spinal cord injury.

The clinical management of patients with acute brain and spinal cord injury has evolved significantly with the advent of new diagnostic and therapeutic modalities. Acute Brain and Spinal Cord Injury presents the latest medical science and highlights controversies in the clinical management of patients with acute brain and spinal cord injuries.Divided into five sections—traumatic brain injury, ischemic stroke, intracerebral and subarachnoid hemorrhage, and spinal cord injury—this text: Delineates diagnostic and monitoring tools, pharmacotherapies, and interventional and surgical treatments Examines and explores recently published laboratory trials and research Incorporates over 50 diagrams and figures for concise communication of scientific information This stand-alone reference is a powerful tool in helping today’s neurologists and neurosurgeons keep abreast of current advancements in brain and spinal cord injury.

Filled with an abundance of reader-friendly and quick-reference tables and figures, this Fourth Edition spans the etiology, epidemiology, clinical features, diagnosis, pathology, and treatment of multiple sclerosis (MS). Surpassing other texts on the topic, this reference provides recommendations and research updates from renowned authorities in the discipline and includes chapters on recent advances in neuroimaging, molecular biology, genetics, proteinomics, disease management, and combination therapy.

As many as 250,000 people in the United States have dystonia, making it the third most common movement disorder following essential tremor and Parkinson's disease.Authoritative and reader-friendly, Handbook of Dystonia, Second Edition provides a wide-ranging overview of the latest research and developments regarding the pathogenesis, evaluation, and management of the disease. The book offers detailed coverage of every available treatment option for dystonia and includes four categorized sections on medical management, botulinum toxin injections, phenol and neurolytic therapy, and surgical intervention.The book reviews the genetic factors of dystonia and supplies in-depth coverage of the neuroanatomy, neurophysiology, and neuropathology of the disease. It covers secondary causes of dystonia, including drug-induced and psychogenic presentations. It also examines non-motor symptoms relating to movement disorders and analyzes innovative approaches for treatment including deep brain stimulation.New to the Second Edition: Four new chapters dedicated to the discussion of individual botulinum toxins recently approved to treat dystonia: Botox, Myobloc, Disport, and XeominDystonic symptoms associated with Parkinson’s disordersThe use of Transcranial Magnetic Stimulation (TMS) as a treatment option for dystoniaSpasticity and its pathogenesis, evaluation, and treatment with toxins, other injectables and surgical therapiesSummarizing what is known about the disorder, the book dramatically improves the recognition and understanding of this debilitating disease.