AFIP Atlas of Tumor and Non-Tumor Pathology, Series 5 – serie

Free digital access available with every print purchase. See inside the book for more details.The placenta is an organ often neglected by surgical pathologists and clinicians alike. Placental diagnoses provide risk assessment for infant prognosis, recurrent risk for future pregnancies, and explanatory findings. There is widespread interest in placental diagnosis for the antenatal determinants of adult disease, inborn errors of metabolism, specific infections, malignancies, and assessing placental function in real time with the ultimate goal of affecting treatment. Due to the difficulties inherent in studying human gestation and gestational pathologies, much of what is known about the relevance of placental pathology is biased toward personal experience and retrospective studies. However, this book presents evidence-based information to the reader. The authors emphasize the need for an educated and directed sampling of the placenta through gross examination which will result in a better and more useful final diagnosis.

This latest version of the Atlas of Non-melanocytic Tumors of the Skin is rich in illustrations, aimed to highlight important diagnostic aspects of individual cutaneous epithelial, mesenchymal, hematopoietic and lymphoid tumors, and to delineate their morphologic spectrum. The images are supplemented by concise text to emphasize the salient clinical and histologic features, differential diagnosis, and the use of immunohistochemistry and other ancillary tests. The goal is to provide a practical diagnostic guide that will serve as a useful resource for dermatopathology and surgical pathology practice.

Free digital access available with every print purchase. See inside the book for more details.The primary goal of this fascicle is to be a practical reference for pathologists who review liver biopsies, a most challenging area of diagnostic surgical pathology. It is focused on diagnostic histopathology, discussing and lavishly illustrating disease patterns with an emphasis on differential diagnosis. The key aspects of clinical features, laboratory findings, and pathophysiology are woven into this book. The application and interpretation of special stains and immunohistochemistry are integrated into discussions of each disease pattern.

Since the 4th Series of this Fascicle was published, there have been considerable advances in our understanding of tumors within the serosal membranes, in particular the classification of mesothelial tumors and their genetics. This 5th Series Fascicle aligns with the terminology recommended by the WHO in its most recent edition for pleural and pericardial tumors, with expansion to reflect serosal membranes at other sites and including recognition of mesothelioma in situ.

Free digital access available with every print purchase. See inside the book for more details.How does a pathologist become interested and develop expertise in testicular and paratesticular neoplasms, which are relatively uncommon? The truth is simple—the opportunity to see many cases. The authors of this 5th Series Fascicle have such expertise and share a remarkable range of cases from their institutions as well as from many pathologists throughout the world who have sent them cases in consultation over the years. This fascicle is rich source of material that will be a great resource for practicing pathologists and pathologists in training.

Free digital access available with every print purchase. See inside the book for more details.In endocrine pathology, surgical pathologists often concentrate on neoplasms at the expense of nonneoplastic disease processes. This is unfortunate as nonneoplastic endocrine disorders are many times more common in the population. As in all fields of medicine, nonneo¬plastic endocrine diseases can closely mimic the neoplastic; an awareness of all aspects of pathology underpins routine clinical practice. This Fifth Series Fascicle offers pathologists and clinicians an opportunity to develop an increased understanding of nontumor endocrine pathology in order to inform patient care.

Free digital access available with every print purchase. See inside the book for more details.The classification and characteristics of tumors and tumor-like lesions of the female lower genital tract have remained relatively constant over the years, though shifts in nomenclature have occurred, and a comprehensive review of the diverse histomorphology and differential diagnosis of lesions at these sites is of paramount importance. Although female lower genital tract pathology is largely dominated by epithelial tumors, the pathologist will also encounter mesenchymal, melanocytic, and hematopoietic neoplasms. This fascicle provides a comprehensive discussion of these categories with emphasis on their wid¬ening clinical and pathologic spectrum as well as their evolving molecular landscape. The book conveys the authors’ extensive experience as pathologists devoted to women’s health and to ad¬vancing understanding of gynecologic disease.

Free digital access available with every print purchase. See inside the book for more details.While classification of pancreatic neoplasms has not evolved significantly since 2007, data related to the molecular underpinnings that characterize each type of neoplasm have grown exponentially in the past 15 years. The current multimodal study of pancreatic neoplasms has allowed a better understanding of tumor biology, more closely linking the mor¬phologic findings with clinical outcomes and targeted treatment. The prognosis of conventional pancreatic ductal adenocarcinoma remains very poor, but some promise is on the horizon based on novel treatment approaches and the increase in earlier diagnosis. Furthermore, intensive study of other pancreatic neoplasms has led to a clearer recognition that each type has distinctive biology and behavior that is often not so highly aggressive. This sense of optimism may help drive a resurgence of interest in pancreatic pathology.

The complexity of ovary and fallopian tube pathology is striking, with dozens of tumor types. There is a greater appreciation now of the importance of hereditary cancer syndromes in ovarian and tubal malignancies, as two common autosomal dominant hereditary cancer predisposition syndromes include carcinomas of ovary or fallopian tube. This book is organized following the structure and terminology of the World Health Organization (WHO) classification of Female Genital Tumors, 5th edition. It includes some new entities that have been described since that book's publication in 2020 and provides detailed discussion of differential diagnosis, relevant ancillary tests, and strategies to approach diagnosis. In addition, discussions of the underlying biology of these tumors, as it relates to their diagnosis, are also presented. This fascicle provides an opportunity for deeper reading and quiet reflection about the progress that has been made in our understanding of tumors of the ovary since the previous landmark edition was published in 1998, as well as a respect for the numerous challenges that remain.Free digital access available with every print purchase. See inside the book for more details.

This new volume on the heart and great vessels has been expanded to become a comprehensive atlas of all cardiovascular disease, both neoplastic and non-neoplastic. In the spirit of prior editions, correlation of expertly curated pathology photographs and photomicrographs with clinical presentation, imaging and molecular genetics remains the cornerstone. The spectrum of cardiovascular disease, both congenital and acquired, is vast; accounting for the relative size of this fascicle. Every attempt has been made to focus on the clinically-relevant features of the diseases helping not only pathologists, but also providing cardiologists, radiologists, and surgeons a reference to understand the pathologic basis of the conditions they diagnose and treat each day. The authors have meticulously provided gross photographs that mirror (where possible) planar imaging techniques that will enable pathologic-radiologic correlation and facilitate a multidisciplinary approach to patient care.Free digital access available with every print purchase. See inside the book for more details.

Much has changed in the detection, diagnosis, and management of breast diseases since the previous editions of this fascicle, in particular for patients with invasive breast carcinoma. This fifth series edition conveys the challenges of diagnostic breast pathology, as well as excitement about the advances that have been, and have yet to be, made in the field.Access the content online for free with every print purchase.

This atlas was written for general pathologists, dermatopathologists, and pathologists in training with an interest in practical diagnostic issues in the pathology of melanocytic tumors. The focus of this fascicle is on microscopic clues for diagnosis, in particular for the distinction of melanocytic nevi from melanoma. The authors also discuss the role of ancillary methods and their potential value as well as limitations in test sensitivity and specificity. This volume will help pathologists provide the most accurate diagnoses in service of their clinical care teams and their patients.

The field of infectious diseases has advanced by leaps and bounds. These advances include the emergence and identification of a plethora of new human pathogens, the reclassi¬fication and renaming of many existing organisms, a clearer understanding of the pathogenesis of infectious diseases, the advent of revolutionary new diagnostic techniques, as well as the development of newer, more efficacious, and safer med¬ical therapies. In addition, the ease of international travel and global human migration have exposed medical practitioners worldwide to an expanding spectrum of infectious diseases.This volume endeavors to update the enormous advances in non-helminth infectious disease pathology and serve as a useful and contemporary reference for surgical pathologists in the continuously evolving and vibrant field of infectious diseases.

The tumors that arise in the adrenals and extra-adrenal paraganglia are not only structurally and hormonally complex, they are also intriguing at the molecular level, where many are recognized as components and harbingers of familial genetic tumor syndromes encompassing a variety of mutations affecting diverse signaling pathways. Building on the foundation laid by the fourth series volume, this fifth series ARP Fascicle summarizes and illustrates the large body of knowledge in this field to provide a comprehensive reference for the clinical, biochemical, radiologic, histologic, immunohistochemical, and molecular features of the various tumors and tumor-like conditions that affect the adrenals and extra-adrenal paraganglia.

The head and neck region is a marvel of anatomic complexity and it encompasses a broad array of subsites, each with its own ar¬chitectural nuances. This histologic richness begets a commensurate diversity of disease. Advances in our understanding of the genetic and epigenetic alterations that underlie many of these tumors have not only refined their classification, but also reshaped our approaches to diagnosis, prognosis, and therapy. This Fascicle reflects these scientific and diagnostic evolutions. Departing from prior editions this volume is organized by anatomic subsite. Each chapter delves into the neoplastic conditions and key differential diagnoses germane to a specific location. This anatomic framework is intended to provide readers with a more practical and intuitive means of navigating the field. This Fascicle serves as a useful companion - equal parts atlas, reference, and diagnostic confidant - for pathologists encountering the intricate, fascinating, and occasionally exasperating world of head and neck pathology.

This updated fascicle is your essential guide to thyroid and parathyroid tumors, reflecting a decade of significant advancements. It adopts the 5th edition of the WHO classification, offering detailed histologic findings with a strong emphasis on differential diagnosis. You'll find comprehensive explanations of molecular pathology and genetic alterations, with sections on molecular profiles in each chapter dedicated to a histologic thyroid or parathyroid entity to aid diagnosis. The thyroid cytology chapter has been extensively remodeled and expanded given the importance of preoperative diagnosis in the management of thyroid nodules and now follows the current Bethesda System for Reporting Thyroid Cytopathology. Plus, all chapters include the latest on prognosis and therapy, based on guidelines from the American Thyroid Association and National Comprehensive Cancer Network. Designed to empower pathologists and other physicians, this fascicle helps you better understand, diagnose, predict the behavior of, and guide the management of patients afflicted with tumors and related lesions of these organs.

Since the publication of the previous edition of the Tumors of the Central Nervous System there have been impactful discoveries, evolving diagnostic classifications, and rapid technical advances that have significantly reshaped the field. In the spirit of the original series, this atlas keeps diagnostic pathology at the core of the discussion, reinforced by a wide array of illustrative material to support the practicing diagnostic pathologist who encounters these tumors and pseudoneoplastic conditions in daily practice to make a meaningful contribution to the care of patients we are privileged to serve.

The human skin, as the largest organ of the body, is home to numerous neoplastic and non-neoplastic disorders. The vast majority of non-neoplastic skin diseases are inflammatory in nature, while a small subset is non-inflammatory. This book covers 194 non-neoplastic dermatologic conditions, classified by their primary microscopic tissue reaction patterns. Our aim is to provide a concise, practical, and up-to-date review of these diseases. We offer a discussion on the clinical presentation, histopathologic features, pathogenesis, differential diagnosis, and management for each entity. One of the key attributes of this clinical atlas is the abundant collection of clinical and microscopic images used to illustrate the salient features of these disorders. In this book, we will focus on inflammatory dermatoses, which encompass a wide range of dermatologic conditions that can be challenging to diagnose due to significant overlaps in clinical and histopathologic features. Dermatopathologists are more likely to encounter unusual or ambiguous cases that are particularly difficult to classify. The interpretation of non-neoplastic skin biopsies requires not only microscopic pattern recognition but also careful integration of clinical history, laboratory data, and other ancillary findings, wherever available, to render the most appropriate diagnoses. We hope that this book will help our readers as they interpret challenging skin biopsies for non-neoplastic diagnoses.

Non-Neoplastic Disorders of Bone Marrow is devoted to the evaluation and interpretation of bone marrow and peripheral blood specimens where non-neoplastic disorders can often mimic malignant conditions. Because these processes frequently require the integration of subtle morphologic clues with the clinical context, this practical, morphologically-grounded resource focuses on the spectrum of acquired non-neoplastic processes, selected clonal conditions, and congenital disorders. The volume is organized by etiology—addressing autoimmune diseases, metabolic disorders, nutritional deficiencies, and the effects of toxins and medications—to facilitate linking specific pathologic findings to potential diagnoses. By emphasizing important morphologic, immunophenotypic, genetic, and clinical features, this Fascicle fills this gap for practicing pathologists and trainees by illustrating the distinct morphologic characteristics and practical approach to the broad spectrum of benign blood and bone marrow disorders.

Since its inception in the late 1950s, percutaneous kidney biopsy has remained the definitive gold standard for diagnosing medical renal diseases, transitioning the field from autopsy-based analysis to a dynamic, biopsy-driven discipline. This updated atlas provides a comprehensive guide to the multifaceted practice of nephropathology, which requires the systematic integration of light microscopy, immunofluorescence, and transmission electron microscopy, synthesized with clinical, serologic, radiographic, and genetic data. This volume highlights the evolution of renal pathology, emphasizing the essential collaboration between pathologists and nephrologists in defining disease entities. It reflects the latest advancements in the field, incorporating modern diagnostic techniques such as mass spectrometry for proteomic characterization, accessible genomic panels, and novel antibody markers for precise immunophenotyping. The atlas is structured to provide a clear, logical framework for diagnosis, beginning with foundational embryology and normal histopathology. Subsequent sections are organized by standardized disease patterns and entities, covering: · Congenital and hereditary diseases. · Acquired diseases of the native kidney, systematically categorized by their impact on glomerular, tubulointerstitial, and vascular compartments. · Diseases of the kidney allograft. .Adhering to the most current consensus terminology from the Renal Pathology Society and the International Society of Nephrology, this book serves as an essential resource. By balancing a comprehensive, evidence-based text with an extensive, collection of diagnostic images, this atlas offers both a vital educational tool and a practical reference for navigating the unique complexities of modern nephropathology.

Free digital access available with every print purchase. See inside the book for more details.Since the last edition of the Tumors of Prostate Gland, Seminal Vesicles, Penis, and Scrotum, there have been numerous significant developments in the diagnosis and treatment of prostate and penile cancers. The new Fifth Series Fascicle of the AFIP Atlas of Tumor and Non-tumor Pathology includes these developments as well as abundant images and diagrams to depict the morphological spectrum of disease entities. In this richly illustrated atlas, the authors emphasize the gross and light microscopic diagnosis and differential diagnosis, present immunohistochemistry and molecular pathology studies that are of current value in diagnosis, and discuss pathological diagnosis in terms of prognosis and treatment.

Free digital access available with every print purchase. See inside the book for more details.This book has built on the work that was presented in the previous Fascicles of the Third and Fourth Series. The authors' vast experience has led to new understanding of many aspects of pituitary pathology. With modern immunostaining and molecular techniques, classification of pituitary disease is becoming easier. Furthermore, the availability of targeted therapies has augmented the role of the pathologist in determining an accurate diagnosis. This updated volume addresses modern techniques and their application to treatment of pituitary neoplasms but retains the detailed foundation of morphology in a lushly illustrated tome, the cornerstone of the AFIP fascicles.

Free digital access available with every print purchase. See inside the book for more details.There have been numerous significant developments in the diagnosis and treatment of ophthalmic tumors since the last edition of Tumors of the Eye and Ocular Adnexa. This fascicle in the Fifth Series of the AFIP Atlases of Tumor and Non-tumor Pathology includes these developments as well as abundant images to depict ophthalmic pathology. In this richly illustrated volume, the authors emphasize that the pathology of ophthalmic tumors must address not only how to make a correct diagnosis, but also how to guide the ophthalmic surgeon to a treatment plan for the disease while simultaneously preserving a patient's vision.