Victor R. Preedy BSc, PhD, DSc, FRSB, FRSPH, FRSC, FRCPath graduated with an Honours Degree in Biology and Physiology with Pharmacology. After gaining his University of London PhD, he received his Membership of the Royal College of Pathologists. He was later awarded his second doctorate (DSc), for his contribution to protein metabolism in health and disease. He is Professor of Clinical Biochemistry (Hon) at King’s College Hospital and Emeritus Professor of Nutritional Biochemistry at King’s College London. He has Honorary Professorships at the University of Hull, and the University of Suffolk. Professor Preedy was the Founding Director and then long-term Director of the Genomics Centre at King’s College London from 2006 to 2020. Professor Preedy has been awarded fellowships of the Royal Society of Biology, the Royal College of Pathologists, the Royal Society for the Promotion of Health, the Royal Institute of Public Health, the Royal Society for Public Health, the Royal Society of Chemistry and the Royal Society of Medicine. He carried out research when attached to the National Heart Hospital (part of Imperial College London), The School of Pharmacy (now part of University College London) and the MRC Centre at Northwick Park Hospital. He has collaborated with international research groups in Finland, Japan, Australia, USA, and Germany. To his credit, Professor Preedy has published over 750 articles, which includes peer-reviewed manuscripts based on original research, abstracts and symposium presentations, reviews and edited books.

Praise for the previous edition:"The book is written for both practitioners and scientists studying this topic… It is a useful reference for practitioners wanting to expand their available treatment options…This is a comprehensive review of the mechanisms leading to diabetic complications with a specific focus on oxidative stress as well as an important review of antioxidant therapies that have been studied in the diabetic population." --Doody's February 2014

• 1. Oxidative Stress and Diabetes 2. Sources of free radicals in diabetes 3. Oxidative stress and autophagy in diabetes 4. Exosomes and oxidative stress Linking insulin, oxidative stress and mitochondria (author to be aware of overlap with Mitochondrial oxidative stress in diabetes Prof. V. M. Victor) 5. Diabetes, peroxisomes and reactive radical species 6. NADPH oxidase and oxidative stress: implications for diabetes 7. Linking xanthine oxidase and free radicals in diabetic condition 8. Linking arachidonic acid metabolism and oxidative stress: implications for diabetes 9. Linking cytochome P450s, oxidative stress and diabetes 10. Linking heme metabolism, oxidative stress and diabetes microRNAs in linking reactive species and diabetes (where possible author to add other small RNAs to the review) 11. Mitochondrial oxidative stress in diabetes 12. Oxidative stress, diabetes and iron 13. Oxidative stress and diabetic neuropathy 14. Diabetic stroke and oxidative stress 15. Diabetic cardiomyopathy and oxidative stress 16. Oxidative stress in diabetic retinopathy 17. Bone, diabetes and oxidative stress 18. Linking insulin, advanced glycation end products and oxidative stress 19. Metformin, oxidative stress and diabetes 20. SGLT2 inhibitors, diabetes and oxidative stress 21. Antioxidants and Diabetes 22. Effect of Red sage (salvia miltiorrhiza) on antioxidant enzymes in diabetic patients 23. Antioxidant spices and herbs and use in diabetes 24. Resveratrol and oxidative stress in diabetes 25. Vitamin D, oxidative stress and diabetes 26. Glutamine and antioxidant potential in diabetes 27. Herbal Chrysanthemi Flos, oxidative damage and diabetic vascular protection 28. Polyphenols, oxidative stress and vascular damage in diabetes 29. Alpha-tocopherol supplementation, lipid profile and insulin sensitivity in diabetes 30. Vitamin E and vascular protection in diabetes 31. Carotenoids, diabetes and oxidative balance (This must be an original review) 32. Ginkgo biloba, oxidative stress, atherosclerosis protection in diabetes 33. Taurine and cardiac oxidative stress in diabetes 34. Statins, diabetic oxidative stress and vascular tissue 35. Anti-oxidative component of docosahexaenoic acid (DHA) in the brain in diabetes 36. Resveratrol and cerebral arterioles in type 1 diabetes 37. Antioxidant supplements and diabetic retinopathy 38. Neuroprotective lutein in the retina and oxidative stress 39. Anti-oxidant related micronutrients and diabetic retinopathy 40. Pomegranate juice, oxidative stress and the lung in diabetes 41. Antioxidants, Oxidative stress and Pre-eclampsia in Type 1 diabetes 42. Zinc supplementation, diabetic foot and antioxidant capacity 43. Assays and techniques 44. Methods for assaying selenium proteins and metabolites 45. Assessing the antioxidant activities of plants 46. Liquid chromatography-electrospray ionization-tandem mass spectrometry and applications to antioxidant biodiscovery 47. Measurement of Intracellular reactive oxygen species and application 48. Methods for assaying biomarkers of oxidative stress in in vivo studies and applications to diabetes 49. Methods for extracting antioxidants from plants 50. Measurement of Intracellular reactive oxygen species and application Biomarkers of lipid peroxidation 51. Battery tests: DPPH, FRAP and ABTS assays and applications to diabetes 52. Battery tests: Radical-scavenging activity, superoxide radical-scavenging and hydroxyl radical-scavenging assays

Victor R. Preedy BSc, PhD, DSc, FRSB, FRSPH, FRSC, FRCPath graduated with an Honours Degree in Biology and Physiology with Pharmacology. After gaining his University of London PhD, he received his Membership of the Royal College of Pathologists. He was later awarded his second doctorate (DSc), for his contribution to protein metabolism in health and disease. He is Professor of Clinical Biochemistry (Hon) at King’s College Hospital and Emeritus Professor of Nutritional Biochemistry at King’s College London. He has Honorary Professorships at the University of Hull, and the University of Suffolk. Professor Preedy was the Founding Director and then long-term Director of the Genomics Centre at King’s College London from 2006 to 2020. Professor Preedy has been awarded fellowships of the Royal Society of Biology, the Royal College of Pathologists, the Royal Society for the Promotion of Health, the Royal Institute of Public Health, the Royal Society for Public Health, the Royal Society of Chemistry and the Royal Society of Medicine. He carried out research when attached to the National Heart Hospital (part of Imperial College London), The School of Pharmacy (now part of University College London) and the MRC Centre at Northwick Park Hospital. He has collaborated with international research groups in Finland, Japan, Australia, USA, and Germany. To his credit, Professor Preedy has published over 750 articles, which includes peer-reviewed manuscripts based on original research, abstracts and symposium presentations, reviews and edited books.

Praise for the previous edition:"The book is written for both practitioners and scientists studying this topic… It is a useful reference for practitioners wanting to expand their available treatment options…This is a comprehensive review of the mechanisms leading to diabetic complications with a specific focus on oxidative stress as well as an important review of antioxidant therapies that have been studied in the diabetic population." --Doody's February 2014

• 1. Oxidative Stress and Diabetes 2. Sources of free radicals in diabetes 3. Oxidative stress and autophagy in diabetes 4. Exosomes and oxidative stress Linking insulin, oxidative stress and mitochondria (author to be aware of overlap with Mitochondrial oxidative stress in diabetes Prof. V. M. Victor) 5. Diabetes, peroxisomes and reactive radical species 6. NADPH oxidase and oxidative stress: implications for diabetes 7. Linking xanthine oxidase and free radicals in diabetic condition 8. Linking arachidonic acid metabolism and oxidative stress: implications for diabetes 9. Linking cytochome P450s, oxidative stress and diabetes 10. Linking heme metabolism, oxidative stress and diabetes microRNAs in linking reactive species and diabetes (where possible author to add other small RNAs to the review) 11. Mitochondrial oxidative stress in diabetes 12. Oxidative stress, diabetes and iron 13. Oxidative stress and diabetic neuropathy 14. Diabetic stroke and oxidative stress 15. Diabetic cardiomyopathy and oxidative stress 16. Oxidative stress in diabetic retinopathy 17. Bone, diabetes and oxidative stress 18. Linking insulin, advanced glycation end products and oxidative stress 19. Metformin, oxidative stress and diabetes 20. SGLT2 inhibitors, diabetes and oxidative stress 21. Antioxidants and Diabetes 22. Effect of Red sage (salvia miltiorrhiza) on antioxidant enzymes in diabetic patients 23. Antioxidant spices and herbs and use in diabetes 24. Resveratrol and oxidative stress in diabetes 25. Vitamin D, oxidative stress and diabetes 26. Glutamine and antioxidant potential in diabetes 27. Herbal Chrysanthemi Flos, oxidative damage and diabetic vascular protection 28. Polyphenols, oxidative stress and vascular damage in diabetes 29. Alpha-tocopherol supplementation, lipid profile and insulin sensitivity in diabetes 30. Vitamin E and vascular protection in diabetes 31. Carotenoids, diabetes and oxidative balance (This must be an original review) 32. Ginkgo biloba, oxidative stress, atherosclerosis protection in diabetes 33. Taurine and cardiac oxidative stress in diabetes 34. Statins, diabetic oxidative stress and vascular tissue 35. Anti-oxidative component of docosahexaenoic acid (DHA) in the brain in diabetes 36. Resveratrol and cerebral arterioles in type 1 diabetes 37. Antioxidant supplements and diabetic retinopathy 38. Neuroprotective lutein in the retina and oxidative stress 39. Anti-oxidant related micronutrients and diabetic retinopathy 40. Pomegranate juice, oxidative stress and the lung in diabetes 41. Antioxidants, Oxidative stress and Pre-eclampsia in Type 1 diabetes 42. Zinc supplementation, diabetic foot and antioxidant capacity 43. Assays and techniques 44. Methods for assaying selenium proteins and metabolites 45. Assessing the antioxidant activities of plants 46. Liquid chromatography-electrospray ionization-tandem mass spectrometry and applications to antioxidant biodiscovery 47. Measurement of Intracellular reactive oxygen species and application 48. Methods for assaying biomarkers of oxidative stress in in vivo studies and applications to diabetes 49. Methods for extracting antioxidants from plants 50. Measurement of Intracellular reactive oxygen species and application Biomarkers of lipid peroxidation 51. Battery tests: DPPH, FRAP and ABTS assays and applications to diabetes 52. Battery tests: Radical-scavenging activity, superoxide radical-scavenging and hydroxyl radical-scavenging assays

Victor R. Preedy BSc, PhD, DSc, FRSB, FRSPH, FRSC, FRCPath graduated with an Honours Degree in Biology and Physiology with Pharmacology. After gaining his University of London PhD, he received his Membership of the Royal College of Pathologists. He was later awarded his second doctorate (DSc), for his contribution to protein metabolism in health and disease. He is Professor of Clinical Biochemistry (Hon) at King’s College Hospital and Emeritus Professor of Nutritional Biochemistry at King’s College London. He has Honorary Professorships at the University of Hull, and the University of Suffolk. Professor Preedy was the Founding Director and then long-term Director of the Genomics Centre at King’s College London from 2006 to 2020. Professor Preedy has been awarded fellowships of the Royal Society of Biology, the Royal College of Pathologists, the Royal Society for the Promotion of Health, the Royal Institute of Public Health, the Royal Society for Public Health, the Royal Society of Chemistry and the Royal Society of Medicine. He carried out research when attached to the National Heart Hospital (part of Imperial College London), The School of Pharmacy (now part of University College London) and the MRC Centre at Northwick Park Hospital. He has collaborated with international research groups in Finland, Japan, Australia, USA, and Germany. To his credit, Professor Preedy has published over 750 articles, which includes peer-reviewed manuscripts based on original research, abstracts and symposium presentations, reviews and edited books.

Praise for the previous edition:"The book is written for both practitioners and scientists studying this topic… It is a useful reference for practitioners wanting to expand their available treatment options…This is a comprehensive review of the mechanisms leading to diabetic complications with a specific focus on oxidative stress as well as an important review of antioxidant therapies that have been studied in the diabetic population." --Doody's February 2014

• 1. Oxidative Stress and Diabetes 2. Sources of free radicals in diabetes 3. Oxidative stress and autophagy in diabetes 4. Exosomes and oxidative stress Linking insulin, oxidative stress and mitochondria (author to be aware of overlap with Mitochondrial oxidative stress in diabetes Prof. V. M. Victor) 5. Diabetes, peroxisomes and reactive radical species 6. NADPH oxidase and oxidative stress: implications for diabetes 7. Linking xanthine oxidase and free radicals in diabetic condition 8. Linking arachidonic acid metabolism and oxidative stress: implications for diabetes 9. Linking cytochome P450s, oxidative stress and diabetes 10. Linking heme metabolism, oxidative stress and diabetes microRNAs in linking reactive species and diabetes (where possible author to add other small RNAs to the review) 11. Mitochondrial oxidative stress in diabetes 12. Oxidative stress, diabetes and iron 13. Oxidative stress and diabetic neuropathy 14. Diabetic stroke and oxidative stress 15. Diabetic cardiomyopathy and oxidative stress 16. Oxidative stress in diabetic retinopathy 17. Bone, diabetes and oxidative stress 18. Linking insulin, advanced glycation end products and oxidative stress 19. Metformin, oxidative stress and diabetes 20. SGLT2 inhibitors, diabetes and oxidative stress 21. Antioxidants and Diabetes 22. Effect of Red sage (salvia miltiorrhiza) on antioxidant enzymes in diabetic patients 23. Antioxidant spices and herbs and use in diabetes 24. Resveratrol and oxidative stress in diabetes 25. Vitamin D, oxidative stress and diabetes 26. Glutamine and antioxidant potential in diabetes 27. Herbal Chrysanthemi Flos, oxidative damage and diabetic vascular protection 28. Polyphenols, oxidative stress and vascular damage in diabetes 29. Alpha-tocopherol supplementation, lipid profile and insulin sensitivity in diabetes 30. Vitamin E and vascular protection in diabetes 31. Carotenoids, diabetes and oxidative balance (This must be an original review) 32. Ginkgo biloba, oxidative stress, atherosclerosis protection in diabetes 33. Taurine and cardiac oxidative stress in diabetes 34. Statins, diabetic oxidative stress and vascular tissue 35. Anti-oxidative component of docosahexaenoic acid (DHA) in the brain in diabetes 36. Resveratrol and cerebral arterioles in type 1 diabetes 37. Antioxidant supplements and diabetic retinopathy 38. Neuroprotective lutein in the retina and oxidative stress 39. Anti-oxidant related micronutrients and diabetic retinopathy 40. Pomegranate juice, oxidative stress and the lung in diabetes 41. Antioxidants, Oxidative stress and Pre-eclampsia in Type 1 diabetes 42. Zinc supplementation, diabetic foot and antioxidant capacity 43. Assays and techniques 44. Methods for assaying selenium proteins and metabolites 45. Assessing the antioxidant activities of plants 46. Liquid chromatography-electrospray ionization-tandem mass spectrometry and applications to antioxidant biodiscovery 47. Measurement of Intracellular reactive oxygen species and application 48. Methods for assaying biomarkers of oxidative stress in in vivo studies and applications to diabetes 49. Methods for extracting antioxidants from plants 50. Measurement of Intracellular reactive oxygen species and application Biomarkers of lipid peroxidation 51. Battery tests: DPPH, FRAP and ABTS assays and applications to diabetes 52. Battery tests: Radical-scavenging activity, superoxide radical-scavenging and hydroxyl radical-scavenging assays