Drug Delivery

"Providing a working foundation in the principles underlying drug transport, reaction, and disappearance in physiological and pathological situations, this introduction and guide covers a range of topics, including drug and protein properties, drug modification and diffusion, and polymeric biomaterials. Case studies, physiological guidelines, and useful nomenclature and data are also featured. Saltzman teaches chemical engineering at CornellUniversity."--SciTech Book News"[A]n excellent addition to the library of any scientist interested in drug delivery systems. Unlike others in the area, this volume is focused on quantitative understanding of the principles that govern rates of drug transport, reaction, and disappearance in physiological conditions. ... even a scientist who may lack a background in mathematics could benefit from this unique discussion of engineering concepts. ... what makes this book outstanding is theability of the author to discus mathematical equations grounded in real examples. ... The book is highly recommended as a textbook in the field of drug delivery ..."--The Quarterly Review of Biology"Providing a working foundation in the principles underlying drug transport, reaction, and disappearance in physiological and pathological situations, this introduction and guide covers a range of topics, including drug and protein properties, drug modification and diffusion, and polymeric biomaterials. Case studies, physiological guidelines, and useful nomenclature and data are also featured. Saltzman teaches chemical engineering at CornellUniversity."--SciTech Book News"[A]n excellent addition to the library of any scientist interested in drug delivery systems. Unlike others in the area, this volume is focused on quantitative understanding of the principles that govern rates of drug transport, reaction, and disappearance in physiological conditions. ... even a scientist who may lack a background in mathematics could benefit from this unique discussion of engineering concepts. ... what makes this book outstanding is theability of the author to discus mathematical equations grounded in real examples. ... The book is highly recommended as a textbook in the field of drug delivery ..."--The Quarterly Review of Biology

• Part I. Introductory material 1: Introduction 2: Drug administration and drug effectiveness Part II. Fundamentals 3: Diffusion and drug dispersion 4: Diffusion in biological systems 5: Drug permeation through biological barriers 6: Drug transport by fluid motion 7: Pharmacokinetics of drug distribution Part III. Drug delivery systems 8: Drug modification 9: Controlled drug delivery systems 10: Case studies in drug delivery 11: Postscript Appendix A. Overview of polymeric biomaterials A1. Nondegradable polymers A2. Biodegradable polymers A3. Water-soluble polymers Appendix B. Useful data and nomenclature B1. Physiological parameters B2. Cardiovascular system B3. Clinical chemistry B4. Permeation and diffusion B5. Protein properties B6. Mathematical tables and functions B7. Nomenclature Index