Colin A. Espie is Professor of Sleep Medicine in the Sleep & Circadian Neuroscience Institute, University of Oxford. He is Founding Director of Experimental and Clinical Sleep Medicine research, and Clinical Director of the Oxford Online Programme in Sleep Medicine. He is also Emeritus Professor of Clinical Psychology, University of Glasgow. He is internationally known for his work on insomnia and its treatment, using cognitive behavioral therapeutics (CBTx), with a focus on making effective therapy available at scale. He has published more than 300 scientific papers and several textbooks and has many professional commitments to national and international sleep societies and journals. He co-founded Big Health, developer of Sleepio™, a CBTx program for insomnia, now widely available in NHS-UK and in US healthcare systems.Phyllis C. Zee is the Benjamin and Virginia T. Boshes Professor in Neurology and Professor of Neurobiology at Northwestern University, as well as Director of theCenter for Circadian & Sleep Medicine (CCSM) and Chief of the Division of Sleep Medicine at Northwestern University's Feinberg School of Medicine. She oversees an interdisciplinary program in translational sleep and circadian rhythm research and a central theme of her research program is understanding the role of circadian-sleep interactions on the expression and development of cardiometabolic and neurologic disorders. She has published more than 300 scientific papers and findings from her team have paved the way for innovative approaches to improve sleep and circadian health.Charles M. Morin is Professor of Psychology and Director of the Sleep Research Centre at Université Laval in Quebec City. He holds a Canada Research Chair on behavioral sleep medicine. Professor Morin is a world leader on insomnia research. He has been at the forefront of new developments on behavioral approaches to treating insomnia and studying the natural history of insomnia with its risk factors and long-termconsequences. He has held several leadership positions in the field of sleep medicine, including as President of the World Sleep Society and the Canadian Sleep Society. He is currently an Associate Editor for the journals SLEEP and for Behavioral Sleep Medicine. Professor Morin has published 10 books and more than 300 articles, and these writings have been instrumental in enhancing the standards of clinical care for patients affected with sleep disorders.

• Introduction Section 1: The Fundamentals of Sleep and Circadian Processes Chapter 1: Sleep and the BrainLilia Roshchupkina, Charline Urbain, and Philippe Peigneux Chapter 2: The Regulation of Human Sleep and Wakefulness: Sleep Homeostasis and Circadian RhythmicityDerk-Jan Dijk and Alpar S. Lazar Chapter 3: Sleep and Circadian Development in the Early and Developing YearsInnessa Donskoy and Temitayo Oyegbile-Chidi Chapter 4: Sleep and Circadian Development in Adults and Older AdultsJeanne F. Duffy, Arturo Arrona-Palacios, and Pamela Song Chapter 5: The Genetics of SleepJames B. Jaggard, Keri J. Ngo, and Philippe Mourrain Chapter 6: Local SleepVladyslav V. Vyazovskiy and Thomas Andrillon Section 2: The Roles and Functions of Sleep Chapter 7: Why We SleepH. Craig Heller Chapter 8: Brain Clearance, Sleep, and Circadian Rhythms: Implications for Brain HealthEva M. van Heese, Erik N.T.P. Bakker, and Ysbrand D. van der Werf Chapter 9: Sleep and Circadian Rhythms and MetabolismAnne-Marie Chang, Praneet C. Kaki, Robin K. Yuan, Christopher M. Depner, and Orfeu M. Buxton Chapter 10: Sleep, Neurocognitive Function, Learning, and MemoryDaniel Baena, Alyssa Pozzobon, Joel Hordijk, Laura B. Ray, and Stuart M. Fogel Chapter 11: Sleep and Human PerformanceCourtney A. Kurinec, Jonah A. Scott, and Hans P. A. Van Dongen Chapter 12: Sleep and Emotion RegulationDebora Meneo, Monica Martoni, and Chiara Baglioni Chapter 13: Sleep, Dreams, and DreamingJoseph De Koninck Section 3: Societal Factors Influencing Sleep Chapter 14: Multidimensional Sleep Health: An Emerging Framework for Understanding Sleep in Relation to Multiple Health OutcomesCaitlan A. Tighe, Meredith L. Wallace, Rachel P. K. Conlon, Marquis S. Hawkins, Christopher C. Imes, and Daniel J. Buysse Chapter 15: Sleep, Social Inequalities, and Societal CostsMari Hysing, Tormod Bøe, and Børge Sivertsen Chapter 16: Sleep, Health, and Shift WorkSiri Waage and Bjørn Bjorvatn Chapter 17: Sex Differences in SleepFiona C. Baker, Rena Wang, and Helen S. Driver Chapter 18: The Impact of Prescription and Recreational Drugs on SleepKai Spiegelhalder, Christoph Nissen, and Dieter Riemann Chapter 19: Bedtime Social Media Use and Sleep: A New Understanding of Social, Emotional, and Cognitive ProcessesHolly Scott and Heather Cleland Woods Section 4: Disorders of Sleep and Circadian Function: Epidemiology, Classification, and Assessment Chapter 20: The Epidemiology of Sleep and Circadian DisordersKatie Stone and Qian Xiao Chapter 21: Sleep Disorders: Classification and DiagnosisJack D. Edinger, Ana I. Fins, and Charles M. Morin Chapter 22: Value-Based Clinical Sleep Medicine: Health Economic Considerations Regarding Insomnia and Obstructive Sleep ApneaEmerson M. Wickwire Chapter 23: Clinical Assessment of Sleep-Wake ComplaintsJason C. Ong, Colin A. Espie, and James K. Wyatt Chapter 24: Actigraphy and Behavioral Assessments of Sleep and Circadian DisordersMonica R. Kelly, Nathaniel Yuan, Alexander J. Erickson, and Jennifer L. Martin Chapter 25: Polysomnography and Emerging Technologies to Evaluate Sleep DisordersThomas Penzel, Ingo Fietze, Martin Glos, Matthew Salanitro, and Lisa Rosenblum Section 5: Disorders of Sleep and Circadian Function: Management and Treatment Chapter 26: Insomnia I: Conceptualization and EtiologyHannah Scott, Philip Gehrman, and Michael Perlis Chapter 27: Insomnia II: Behavioral and Physiological AssessmentCélyne H. Bastien, Jason G. Ellis, Florence Lambert-Beaudet, Alexandre Rudziavick-Provençal, and Elham Garmroudinezhad-Rostami Chapter 28: Cognitive Behavioral Therapies for Insomnia: Current Status and Challenges AheadCharles M. Morin and Simon D. Kyle Chapter 29: Parasomnias I: NightmaresSerena Scarpelli, Valentina Alfonsi, and Luigi De Gennaro Chapter 30: Parasomnias II: REM Sleep Behavior DisorderAlex Iranzo Chapter 31: Parasomnias III: Sleep Terrors and SomnambulismAntonio Zadra and Francesca Siclari Chapter 32: Circadian Rhythm Sleep-Wake Disorders I: Phase-Advanced and Phase-Delayed SyndromesLeon Lack, Gorica Micic, and Nicole Lovato Chapter 33: Shift Work, Irregular, and Non-24-Hour Sleep-Wake Rhythm DisordersDiane B. Boivin and Philippe Boudreau Chapter 34: Sleep-Related Breathing Disorders I: Physiology and EtiologyDanny J. Eckert Chapter 35: Sleep-Related Breathing Disorders II: Clinical ManagementAmy M. Sawyer, Alexa J. Watach, Bruno Saconi, and Lindsey Clark Chapter 36: Narcolepsies and Other Central Hypersomnolence DisordersYves Dauvilliers and Lucie Barateau Chapter 37: Restless Legs Syndrome and Periodic Limb Movement DisorderRaquel Martín, Celia García-Malo, Elisa Gamo, Alejandro Herrero, Sofía Romero, Alba García, and Diego García-Borreguero Section 6: Disorders of Sleep and Circadian Function: Lifespan Issues and Special Populations Chapter 38: Sleep-Related Problems in Childhood and AdolescenceLiat Tikotzky, Michal Kahn, Michael Gradisar, and Oliviero Bruni Chapter 39: Sleep Disorders in the ElderlyAli Amidi, Sonia Ancoli-Israel, Jeanne E. Maglione, and Lisa M. Wu Chapter 40: Sleep and Psychiatric DisordersRachel Manber, Jessica R. Dietch, Nicole B. Gumport, and Norah Simpson Chapter 41: Women's Sleep and Circadian Rhythms From Puberty to Menopausal TransitionBilgay Izci Balserak and Kathy Aldrich Lee Chapter 42: Sleep and Medical Disorders Leanne Fleming, Megan Crawford, Bethany Martin, Mhairi Patience, and Samantha Fisher-Hicks Chapter 43: Sleep in Patients With Substance Use DisordersM. Elizabeth Cardoni, Bhanu Prakash Kolla, Mandilyn Graham, Yosef Bronsteyn, and J. Todd Arnedt Chapter 44: Sleep-Wake Disturbances in Individuals With Traumatic Brain InjuryMarie-Christine Ouellet, Simon Beaulieu-Bonneau, and Charles M. Morin Chapter 45: Sleep in People With Intellectual DisabilitiesLuci D. Wiggs Chapter 46: Sexsomnia and Sexual Assault: The Role of the Sleep Forensics Investigator in CourtMichel A Cramer Bornemann and Carlos H. Schenck

Colin A. Espie is Professor of Sleep Medicine in the Sleep & Circadian Neuroscience Institute, University of Oxford. He is Founding Director of Experimental and Clinical Sleep Medicine research, and Clinical Director of the Oxford Online Programme in Sleep Medicine. He is also Emeritus Professor of Clinical Psychology, University of Glasgow. He is internationally known for his work on insomnia and its treatment, using cognitive behavioral therapeutics (CBTx), with a focus on making effective therapy available at scale. He has published more than 300 scientific papers and several textbooks and has many professional commitments to national and international sleep societies and journals. He co-founded Big Health, developer of Sleepio™, a CBTx program for insomnia, now widely available in NHS-UK and in US healthcare systems.Phyllis C. Zee is the Benjamin and Virginia T. Boshes Professor in Neurology and Professor of Neurobiology at Northwestern University, as well as Director of theCenter for Circadian & Sleep Medicine (CCSM) and Chief of the Division of Sleep Medicine at Northwestern University's Feinberg School of Medicine. She oversees an interdisciplinary program in translational sleep and circadian rhythm research and a central theme of her research program is understanding the role of circadian-sleep interactions on the expression and development of cardiometabolic and neurologic disorders. She has published more than 300 scientific papers and findings from her team have paved the way for innovative approaches to improve sleep and circadian health.Charles M. Morin is Professor of Psychology and Director of the Sleep Research Centre at Université Laval in Quebec City. He holds a Canada Research Chair on behavioral sleep medicine. Professor Morin is a world leader on insomnia research. He has been at the forefront of new developments on behavioral approaches to treating insomnia and studying the natural history of insomnia with its risk factors and long-termconsequences. He has held several leadership positions in the field of sleep medicine, including as President of the World Sleep Society and the Canadian Sleep Society. He is currently an Associate Editor for the journals SLEEP and for Behavioral Sleep Medicine. Professor Morin has published 10 books and more than 300 articles, and these writings have been instrumental in enhancing the standards of clinical care for patients affected with sleep disorders.

• Introduction Section 1: The Fundamentals of Sleep and Circadian Processes Chapter 1: Sleep and the BrainLilia Roshchupkina, Charline Urbain, and Philippe Peigneux Chapter 2: The Regulation of Human Sleep and Wakefulness: Sleep Homeostasis and Circadian RhythmicityDerk-Jan Dijk and Alpar S. Lazar Chapter 3: Sleep and Circadian Development in the Early and Developing YearsInnessa Donskoy and Temitayo Oyegbile-Chidi Chapter 4: Sleep and Circadian Development in Adults and Older AdultsJeanne F. Duffy, Arturo Arrona-Palacios, and Pamela Song Chapter 5: The Genetics of SleepJames B. Jaggard, Keri J. Ngo, and Philippe Mourrain Chapter 6: Local SleepVladyslav V. Vyazovskiy and Thomas Andrillon Section 2: The Roles and Functions of Sleep Chapter 7: Why We SleepH. Craig Heller Chapter 8: Brain Clearance, Sleep, and Circadian Rhythms: Implications for Brain HealthEva M. van Heese, Erik N.T.P. Bakker, and Ysbrand D. van der Werf Chapter 9: Sleep and Circadian Rhythms and MetabolismAnne-Marie Chang, Praneet C. Kaki, Robin K. Yuan, Christopher M. Depner, and Orfeu M. Buxton Chapter 10: Sleep, Neurocognitive Function, Learning, and MemoryDaniel Baena, Alyssa Pozzobon, Joel Hordijk, Laura B. Ray, and Stuart M. Fogel Chapter 11: Sleep and Human PerformanceCourtney A. Kurinec, Jonah A. Scott, and Hans P. A. Van Dongen Chapter 12: Sleep and Emotion RegulationDebora Meneo, Monica Martoni, and Chiara Baglioni Chapter 13: Sleep, Dreams, and DreamingJoseph De Koninck Section 3: Societal Factors Influencing Sleep Chapter 14: Multidimensional Sleep Health: An Emerging Framework for Understanding Sleep in Relation to Multiple Health OutcomesCaitlan A. Tighe, Meredith L. Wallace, Rachel P. K. Conlon, Marquis S. Hawkins, Christopher C. Imes, and Daniel J. Buysse Chapter 15: Sleep, Social Inequalities, and Societal CostsMari Hysing, Tormod Bøe, and Børge Sivertsen Chapter 16: Sleep, Health, and Shift WorkSiri Waage and Bjørn Bjorvatn Chapter 17: Sex Differences in SleepFiona C. Baker, Rena Wang, and Helen S. Driver Chapter 18: The Impact of Prescription and Recreational Drugs on SleepKai Spiegelhalder, Christoph Nissen, and Dieter Riemann Chapter 19: Bedtime Social Media Use and Sleep: A New Understanding of Social, Emotional, and Cognitive ProcessesHolly Scott and Heather Cleland Woods Section 4: Disorders of Sleep and Circadian Function: Epidemiology, Classification, and Assessment Chapter 20: The Epidemiology of Sleep and Circadian DisordersKatie Stone and Qian Xiao Chapter 21: Sleep Disorders: Classification and DiagnosisJack D. Edinger, Ana I. Fins, and Charles M. Morin Chapter 22: Value-Based Clinical Sleep Medicine: Health Economic Considerations Regarding Insomnia and Obstructive Sleep ApneaEmerson M. Wickwire Chapter 23: Clinical Assessment of Sleep-Wake ComplaintsJason C. Ong, Colin A. Espie, and James K. Wyatt Chapter 24: Actigraphy and Behavioral Assessments of Sleep and Circadian DisordersMonica R. Kelly, Nathaniel Yuan, Alexander J. Erickson, and Jennifer L. Martin Chapter 25: Polysomnography and Emerging Technologies to Evaluate Sleep DisordersThomas Penzel, Ingo Fietze, Martin Glos, Matthew Salanitro, and Lisa Rosenblum Section 5: Disorders of Sleep and Circadian Function: Management and Treatment Chapter 26: Insomnia I: Conceptualization and EtiologyHannah Scott, Philip Gehrman, and Michael Perlis Chapter 27: Insomnia II: Behavioral and Physiological AssessmentCélyne H. Bastien, Jason G. Ellis, Florence Lambert-Beaudet, Alexandre Rudziavick-Provençal, and Elham Garmroudinezhad-Rostami Chapter 28: Cognitive Behavioral Therapies for Insomnia: Current Status and Challenges AheadCharles M. Morin and Simon D. Kyle Chapter 29: Parasomnias I: NightmaresSerena Scarpelli, Valentina Alfonsi, and Luigi De Gennaro Chapter 30: Parasomnias II: REM Sleep Behavior DisorderAlex Iranzo Chapter 31: Parasomnias III: Sleep Terrors and SomnambulismAntonio Zadra and Francesca Siclari Chapter 32: Circadian Rhythm Sleep-Wake Disorders I: Phase-Advanced and Phase-Delayed SyndromesLeon Lack, Gorica Micic, and Nicole Lovato Chapter 33: Shift Work, Irregular, and Non-24-Hour Sleep-Wake Rhythm DisordersDiane B. Boivin and Philippe Boudreau Chapter 34: Sleep-Related Breathing Disorders I: Physiology and EtiologyDanny J. Eckert Chapter 35: Sleep-Related Breathing Disorders II: Clinical ManagementAmy M. Sawyer, Alexa J. Watach, Bruno Saconi, and Lindsey Clark Chapter 36: Narcolepsies and Other Central Hypersomnolence DisordersYves Dauvilliers and Lucie Barateau Chapter 37: Restless Legs Syndrome and Periodic Limb Movement DisorderRaquel Martín, Celia García-Malo, Elisa Gamo, Alejandro Herrero, Sofía Romero, Alba García, and Diego García-Borreguero Section 6: Disorders of Sleep and Circadian Function: Lifespan Issues and Special Populations Chapter 38: Sleep-Related Problems in Childhood and AdolescenceLiat Tikotzky, Michal Kahn, Michael Gradisar, and Oliviero Bruni Chapter 39: Sleep Disorders in the ElderlyAli Amidi, Sonia Ancoli-Israel, Jeanne E. Maglione, and Lisa M. Wu Chapter 40: Sleep and Psychiatric DisordersRachel Manber, Jessica R. Dietch, Nicole B. Gumport, and Norah Simpson Chapter 41: Women's Sleep and Circadian Rhythms From Puberty to Menopausal TransitionBilgay Izci Balserak and Kathy Aldrich Lee Chapter 42: Sleep and Medical Disorders Leanne Fleming, Megan Crawford, Bethany Martin, Mhairi Patience, and Samantha Fisher-Hicks Chapter 43: Sleep in Patients With Substance Use DisordersM. Elizabeth Cardoni, Bhanu Prakash Kolla, Mandilyn Graham, Yosef Bronsteyn, and J. Todd Arnedt Chapter 44: Sleep-Wake Disturbances in Individuals With Traumatic Brain InjuryMarie-Christine Ouellet, Simon Beaulieu-Bonneau, and Charles M. Morin Chapter 45: Sleep in People With Intellectual DisabilitiesLuci D. Wiggs Chapter 46: Sexsomnia and Sexual Assault: The Role of the Sleep Forensics Investigator in CourtMichel A Cramer Bornemann and Carlos H. Schenck