Nanotoxicology

Hemant Kumar Daima is A/Professor at Amity University Rajasthan, India and honorary ‘Visiting Research Fellow’ at RMIT University, Melbourne, Australia. Prior to Amity University, he has worked as A/Professor of Nanomedicine at Siddaganga Institute of Technology, India; Research Associate/Tutor at RMIT University, Australia and Research Fellow at University of Rajasthan, India. Dr. Daima obtained his MSc (Biotechnology) from University of Rajasthan, India; PhD (Applied Biology and Nanobiotechnology) from RMIT University, Australia. Dr. Daima is founder of Nano-Bio Interfacial Research Laboratory (NBIRL), and in-charge of newly established Amity University Science and Instrumentation Center-II (AUSIC-II). S. L. Kothari, FBS, FISPM, FNASc, FNAAS is Distinguished Professor of Biotechnology and Vice-President of Amity Science Technology and Innovation Foundation (ASTIF) at Amity University Rajasthan, Jaipur, India. Professor S.L. Kothari graduated from University of Rajasthan, Jaipur, India in 1984 with PhD, and during his long career he held post-doctoral positions as Fulbright Fellow at the University of Illinois, Urbana-Champaign, USA (1983-84); University of Nottingham, UK as Commonwealth Academic Staff Fellow and Rockefeller Foundation Biotechnology Career Fellow (1989-1996); University of Tsukuba, Japan as Visiting Foreign Research Fellow (2003-04). He held academic positions as Professor, Head of Department and Dean Faculty of Science at the University of Rajasthan, Jaipur; and later as Director, Institute of Biotechnology and Pro Vice Chancellor of Amity University Rajasthan, Jaipur. His efforts resulted in to the establishment of Converging Technologies Centre (nano-bio-info-cogno) at the University of Rajasthan, Jaipur that imparts BTech-MTech dual degree in four different streams of Converging Technologies. Suresh Bhargava is Distinguished Professor, Associate Pro Vice-Chancellor (India) and the Founding Director of the Centre for Advanced Materials & Industrial Chemistry at RMIT University, Melbourne, Australia. He obtained his PhD from the University of Exeter, UK and was conferred a DSc (Honoris Causa) by University of Rajasthan, Jaipur, India. Professor Bhargava is a world-renowned interdisciplinary scientist and is recognized for delivering research excellence that underpins significant industrial applications. He published more than 439 journal articles and more than 200 industrial reports.

• Chapter 1 Nanomaterials: Types of Nanomaterials and TheirFundamental Physicochemical Properties....................................... 1A. Shubha, S. R. Manohara, and S. S. SubhranshuChapter 2 Innovations in Nanotechnology for Biomedical Sensing,Imaging, Drug Delivery, and Therapy........................................... 21Anine Crous and Heidi AbrahamseChapter 3 Nanomaterials for Drug Delivery.................................................. 43Shailja Jain, Srividya Gorantla, and Gautam SinghviChapter 4 PLGA-Based Nanoparticulate Systems: New Trends inNanomedicine................................................................................ 73Devendra Jain, Abhijeet Singh, Bjorn John Stephen,Suman Sanadhya, Hemant Kumar Daima,Harishkumar Madhyastha, and Radha MadhyasthaChapter 5 Employing New Targeted Nanoencapsulation forAlzheimer’s Disease Treatment: A Change for the Better?........... 97Arti Devi and Zaved Ahmed KhanChapter 6 Nanomaterials-Assisted Elicitation ofPharmaceutically Important Secondary Metabolites fromIn Vitro Plant Cell Cultures...........................................................117Sekhar Tiwari, Sachin Kumar Verma, Abhishek Bhargava,Anusha Ebenezer Alpheus, Rasanpreet Kaur,Rajesh Sharma, and Neeraj KhareChapter 7 Impact of Nanomaterials on Health and Environment................ 133Faisal Ali, Kanwal Akhtar, Ahmed Nawaz, M. Munir Sajid,Naveed Akhtar Shad, Muhammad Abdul Qayyum, and Yasir JavedChapter 8 Consequences of Nanomaterials on HumanHealth and Ecosystem.................................................................. 157Priyanka Kumari, Richa Seth, and Abha MeenaChapter 9 Conceptual Understanding of the Mechanisms ofNanotoxicity and Safety of Nanomedicines................................. 201Rotimi Damilare, Maimako Rotdelmwa, AshonibareVictory, Ogunnupebi Temitope, and Adeyemi Oluyomi StephenChapter 10 Insights into the Mechanisms of Nanotoxicity andEvaluation of Nanomaterials........................................................ 225Vinod Kumar YataChapter 11 Sensors to Monitor and Evaluate the Toxicity ofNanomedicine Applications......................................................... 245Bambang KuswandiChapter 12 Systems Approaches for ToxicologicalAssessment of Nanomaterials...................................................... 277Hasmik Yepiskoposyan, Marja Talikka,Vincenzo Belcastro, Nikolai V. Ivanov, Diego Marescotti,Manuel C. Peitsch, and Julia HoengChapter 13 Measurement of Oxygen Consumption Rate Based onFluorescence Intensity and Lifetime as a Strategy to AssessNanotoxicity................................................................................. 303T. Sushma, Hemant Kumar Daima, D. R. Ramesh Babu,S. Amutha, and Sangly P. SrinivasChapter 14 Current Knowledge on Toxicity of Nanomaterials:Toxicity Assessment and Impact.................................................. 339Bhaskar Das, Mayuri Chabukdhara, Sanjukta Patra, andManashjit GogoiChapter 15 The Role of Nanotechnology in the Management ofWater Toxicity.............................................................................. 377Vinod Kumar YataChapter 16 Challenges in the Assessment of Nanotoxicity,Recommendations, and Safe-by-Design Nanomedicines toCounter Toxicological Problems.................................................. 393G. V. S. Subbaroy Sarma, Manoj Kumar Enamala,Maria P. Nikolova, Murthy Chavali, andSudhakar Reddy PamanjiChapter 17 Current Guidelines and Regulatory Challenges, Insight intothe Legal, Societal, and Ethical Issues of Nanomaterials............ 445Harjeet Nath, S. S. Subhranshu, and S. R. Manohara