Design and Analysis of Sequential Clinical Trials

Inbunden, Engelska, 1997

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Beskrivning

This book details all aspects of sequential clinical trials from preliminary planning, through the monitoring of the trial, to the final analysis of the results. Emphasis is placed on the triangular test and other procedures based on straight line stopping boundaries. These methods allow for frequent or occasional interim analyses and permit the analysis of a wide variety of patient responses. Alternative procedures are also covered in detail, and these include -spending function methods, repeated confidence intervals and Bayesian approaches to sequential clinical trials.

Produktinformation

Utgivningsdatum:1997-06-25
Mått:165 x 240 x 26 mm
Vikt:624 g
Format:Inbunden
Språk:Engelska
Serie:Statistics in Practice
Antal sidor:328
Upplaga:2
Förlag:John Wiley & Sons Inc
ISBN:9780471975502

Utforska kategorier

Mer om författaren

John Whitehead is the author of The Design and Analysis of Sequential Clinical Trials, Revised, 2nd Edition, published by Wiley.

Recensioner i media

"...This book is clear, it provides many details and is well written..." (Statistical Methods in Medical Research, No.11, 2002)

Innehållsförteckning

Clinical Trials. Allocating Patients to Treatments. Measurement of Treatment Difference. The Design of a Sequential Trial Using the Boundaries Approach. The Analysis of a Sequential Trial. Alternative Approaches to the Design and Analysis of Sequential Clinical Trials. Prognostic Factors. The Comparison of More than Two Treatments. Implementation of Sequential Methods: Some Examples. References. Appendix. Index.