Moshe Hod is the Director, Mor Comprehensive Women’s Health Care Center, Tel-Aviv, IsraelNir Melamed is the Head of Twins Research Centre, Director of Research, Maternal-Fetal Medicine Division, Sunnybrook Health Sciences Centre, University of Toronto, CanadaGian Carlo Di Renzo is a Professor of Obstetrics and Gynecology and Maternal Fetal Medicine, Coordinator of the Reproductive and Perinatal Medicine Center, University of Perugia; Founder and Director, PREIS International School, Firenze, Italy; and Director, Alliance of Global Women’s Medicine, GLOWM, London, UKHema Divakar is a Gynecologist and Obstetrician at Divakar Specialty Hospital, Bangalore, IndiaAlberto de Leiva is the Scientific Director, Fundación DIABEM, Barcelona, SpainLiona Poon is the department Chairperson AND Professor (Clinical), Co-Team Head for Maternal Medicine, Department of Obstetrics and Gynaecology, the Chinese University of Hong Kong and Prince of Wales Hospital, ChinaHuixia Yang is the department Director and Professor for Obstetrics and Gynecology and Reproductive Medicine, and Director for Beijing Key Laboratory of Maternal Fetal Medicine of Gestational Diabetes Mellitus, Peking University First Hospital, Beijing, ChinaYariv Yogev is the Professor and Chairman, Lis Hospital for Women’s Health, Tel Aviv Sourasky Medical Center, and Head of Division of Obstetrics and Gynecology, Faculty of Medicine, Tel Aviv University, Israel

REVIEWS OF PREVIOUS EDITIONSA comprehensive and detailed review of all aspects of management … an excellent reference book and a highly authoritative tome on an increasingly common condition. (Glycosmedia)An excellent job … presenting evidence-based guidance. ... the international perspective is interesting and can add insight.(Doody’s Book Reviews)An excellent general resource ... well-suited for the trainee, particularly in obstetrics, who will care for the pregnant woman with diabetes and her offspring. (New England Journal of Medicine)An excellent resource for all clinicians caring for pregnant women with diabetes. I commend this textbook to any craving a fresh look at an old problem. (Diabetologia)

• In Memoriam: Oded Langer† by Yariv Yogev. Honoring Lois Jovanovič (1947–2018) by Alejandra de Leiva-Pérez and Alberto de Leiva-Hidalgo. Preface. List of Contributors. 1 Prologue: Maternal Medicine Meets Fetal Medicine: Merging the Legacies and Hypotheses. 2 History of Diabetic Pregnancy. 3 Epidemiology of Gestational Diabetes Mellitus. 4 The Great Obstetric Syndromes: The Roots of Disease. 5 Metabolism in Normal and in Diabetic Pregnancy. 6 Nutrient Delivery and Metabolism in the Fetus. 7 Pathogenesis of Gestational Diabetes Mellitus. 8 Autoimmunity in Gestational Diabetes Mellitus. 9 The Placenta in Diabetic Pregnancy. 10 Gestational Diabetes Mellitus: The Consequences of Not Treating. 11 Implications of Diabetic Pregnancy: The Offspring. 12 Short-Term Implications: The Neonate. 13 Implications of Diabetic Pregnancy: The Mother. 14 Gestational Diabetes Mellitus, Obesity and Pregnancy Outcomes. 15 Hypertensive Disorders and Diabetic Pregnancy. 16 Fetal Congenital Malformations in Diabetic Pregnancy. 17 Post-Implantation Diabetic Embryopathy. 18 Congenital Malformations in Diabetic Pregnancy: Prevalence and Types. 19 Reproduction and Its Impact on Health and Disease. 20 Prediction and Prevention of Gestational Diabetes Mellitus. 21 Inositols and Prevention of Gestational Diabetes Mellitus. 22 The Multiomics Approach to Diabetes in Pregnancy. 23 The Role of Bariatric Surgery in Obese Women Planning Pregnancy. 24 The Role of Glucagon-Like Peptide-1 (GLP-1) in Women with Obesity Planning Pregnancy. 25 Diagnosis of Gestational Diabetes Mellitus. 26 Glucose Intolerance in Pregnancy: A Window to Mother and Offspring Future Cardio-Metabolic Risk. 27 Ideal Weight Gain in Pregnancy with Diabetes. 28 Glycemic Goals in Diabetic Pregnancy and Defining "Good Control": Maternal and Fetal Perspective. 29 Medical Nutritional Therapy for Gestational Diabetes Mellitus. 30 Insulin Therapy in Pregnancy. 31 Use of Non-Insulin Antihyperglycemic Drugs in Relation to Pregnancy. 32 Continuous Subcutaneous Insulin Infusion and Continuous Glucose Monitoring in Pregnancy. 33 Periconceptional Assessment in Diabetic Women Planning Pregnancy. 34 Early Pregnancy Loss and Perinatal Mortality. 35 Fetal Surveillance in Diabetic Pregnancies. 36 Timing and Mode of Delivery in Diabetic Pregnancy. 37 Management of the Macrosomic Fetus: Can Fetal Macrosomia Be Predicted and Prevented? 38 Gestational Diabetes in Twin Pregnancies. 39 Fetal Growth Restriction in Diabetic Pregnancies. 40 Diabetes, Obesity, Hypertension, and Preterm Birth. 41 Diabetic Retinopathy. 42 Diabetic Kidney Disease. 43 Diabetic Ketoacidosis. 44 Thyroid In Pregnancy. 45 Gestational Diabetes in Lower- and Middle-Income Countries. 46 Managing Diabetic Pregnancy in China. 47 Links between Maternal Health and Noncommunicable Diseases. 48 Diabetes, Pregnancy, and the Developmental Origins of Health and Disease. 49 Postpartum Management: Mother and Offspring. 50 Non-Invasive Glucose Monitoring. 51 Closed-Loop Insulin Delivery in Type 1 Diabetes Pregnancy. 52 Epilogue: Maternal Fetal Medicine Meets Femtech while Digitalizing Pregnancy Management: Present and Future. Index.

Moshe Hod is the Director, Mor Comprehensive Women’s Health Care Center, Tel-Aviv, IsraelNir Melamed is the Head of Twins Research Centre, Director of Research, Maternal-Fetal Medicine Division, Sunnybrook Health Sciences Centre, University of Toronto, CanadaGian Carlo Di Renzo is a Professor of Obstetrics and Gynecology and Maternal Fetal Medicine, Coordinator of the Reproductive and Perinatal Medicine Center, University of Perugia; Founder and Director, PREIS International School, Firenze, Italy; and Director, Alliance of Global Women’s Medicine, GLOWM, London, UKHema Divakar is a Gynecologist and Obstetrician at Divakar Specialty Hospital, Bangalore, IndiaAlberto de Leiva is the Scientific Director, Fundación DIABEM, Barcelona, SpainLiona Poon is the department Chairperson AND Professor (Clinical), Co-Team Head for Maternal Medicine, Department of Obstetrics and Gynaecology, the Chinese University of Hong Kong and Prince of Wales Hospital, ChinaHuixia Yang is the department Director and Professor for Obstetrics and Gynecology and Reproductive Medicine, and Director for Beijing Key Laboratory of Maternal Fetal Medicine of Gestational Diabetes Mellitus, Peking University First Hospital, Beijing, ChinaYariv Yogev is the Professor and Chairman, Lis Hospital for Women’s Health, Tel Aviv Sourasky Medical Center, and Head of Division of Obstetrics and Gynecology, Faculty of Medicine, Tel Aviv University, Israel

REVIEWS OF PREVIOUS EDITIONSA comprehensive and detailed review of all aspects of management … an excellent reference book and a highly authoritative tome on an increasingly common condition. (Glycosmedia)An excellent job … presenting evidence-based guidance. ... the international perspective is interesting and can add insight.(Doody’s Book Reviews)An excellent general resource ... well-suited for the trainee, particularly in obstetrics, who will care for the pregnant woman with diabetes and her offspring. (New England Journal of Medicine)An excellent resource for all clinicians caring for pregnant women with diabetes. I commend this textbook to any craving a fresh look at an old problem. (Diabetologia)

• In Memoriam: Oded Langer† by Yariv Yogev. Honoring Lois Jovanovič (1947–2018) by Alejandra de Leiva-Pérez and Alberto de Leiva-Hidalgo. Preface. List of Contributors. 1 Prologue: Maternal Medicine Meets Fetal Medicine: Merging the Legacies and Hypotheses. 2 History of Diabetic Pregnancy. 3 Epidemiology of Gestational Diabetes Mellitus. 4 The Great Obstetric Syndromes: The Roots of Disease. 5 Metabolism in Normal and in Diabetic Pregnancy. 6 Nutrient Delivery and Metabolism in the Fetus. 7 Pathogenesis of Gestational Diabetes Mellitus. 8 Autoimmunity in Gestational Diabetes Mellitus. 9 The Placenta in Diabetic Pregnancy. 10 Gestational Diabetes Mellitus: The Consequences of Not Treating. 11 Implications of Diabetic Pregnancy: The Offspring. 12 Short-Term Implications: The Neonate. 13 Implications of Diabetic Pregnancy: The Mother. 14 Gestational Diabetes Mellitus, Obesity and Pregnancy Outcomes. 15 Hypertensive Disorders and Diabetic Pregnancy. 16 Fetal Congenital Malformations in Diabetic Pregnancy. 17 Post-Implantation Diabetic Embryopathy. 18 Congenital Malformations in Diabetic Pregnancy: Prevalence and Types. 19 Reproduction and Its Impact on Health and Disease. 20 Prediction and Prevention of Gestational Diabetes Mellitus. 21 Inositols and Prevention of Gestational Diabetes Mellitus. 22 The Multiomics Approach to Diabetes in Pregnancy. 23 The Role of Bariatric Surgery in Obese Women Planning Pregnancy. 24 The Role of Glucagon-Like Peptide-1 (GLP-1) in Women with Obesity Planning Pregnancy. 25 Diagnosis of Gestational Diabetes Mellitus. 26 Glucose Intolerance in Pregnancy: A Window to Mother and Offspring Future Cardio-Metabolic Risk. 27 Ideal Weight Gain in Pregnancy with Diabetes. 28 Glycemic Goals in Diabetic Pregnancy and Defining "Good Control": Maternal and Fetal Perspective. 29 Medical Nutritional Therapy for Gestational Diabetes Mellitus. 30 Insulin Therapy in Pregnancy. 31 Use of Non-Insulin Antihyperglycemic Drugs in Relation to Pregnancy. 32 Continuous Subcutaneous Insulin Infusion and Continuous Glucose Monitoring in Pregnancy. 33 Periconceptional Assessment in Diabetic Women Planning Pregnancy. 34 Early Pregnancy Loss and Perinatal Mortality. 35 Fetal Surveillance in Diabetic Pregnancies. 36 Timing and Mode of Delivery in Diabetic Pregnancy. 37 Management of the Macrosomic Fetus: Can Fetal Macrosomia Be Predicted and Prevented? 38 Gestational Diabetes in Twin Pregnancies. 39 Fetal Growth Restriction in Diabetic Pregnancies. 40 Diabetes, Obesity, Hypertension, and Preterm Birth. 41 Diabetic Retinopathy. 42 Diabetic Kidney Disease. 43 Diabetic Ketoacidosis. 44 Thyroid In Pregnancy. 45 Gestational Diabetes in Lower- and Middle-Income Countries. 46 Managing Diabetic Pregnancy in China. 47 Links between Maternal Health and Noncommunicable Diseases. 48 Diabetes, Pregnancy, and the Developmental Origins of Health and Disease. 49 Postpartum Management: Mother and Offspring. 50 Non-Invasive Glucose Monitoring. 51 Closed-Loop Insulin Delivery in Type 1 Diabetes Pregnancy. 52 Epilogue: Maternal Fetal Medicine Meets Femtech while Digitalizing Pregnancy Management: Present and Future. Index.

Moshe Hod is the Director, Mor Comprehensive Women’s Health Care Center, Tel-Aviv, IsraelNir Melamed is the Head of Twins Research Centre, Director of Research, Maternal-Fetal Medicine Division, Sunnybrook Health Sciences Centre, University of Toronto, CanadaGian Carlo Di Renzo is a Professor of Obstetrics and Gynecology and Maternal Fetal Medicine, Coordinator of the Reproductive and Perinatal Medicine Center, University of Perugia; Founder and Director, PREIS International School, Firenze, Italy; and Director, Alliance of Global Women’s Medicine, GLOWM, London, UKHema Divakar is a Gynecologist and Obstetrician at Divakar Specialty Hospital, Bangalore, IndiaAlberto de Leiva is the Scientific Director, Fundación DIABEM, Barcelona, SpainLiona Poon is the department Chairperson AND Professor (Clinical), Co-Team Head for Maternal Medicine, Department of Obstetrics and Gynaecology, the Chinese University of Hong Kong and Prince of Wales Hospital, ChinaHuixia Yang is the department Director and Professor for Obstetrics and Gynecology and Reproductive Medicine, and Director for Beijing Key Laboratory of Maternal Fetal Medicine of Gestational Diabetes Mellitus, Peking University First Hospital, Beijing, ChinaYariv Yogev is the Professor and Chairman, Lis Hospital for Women’s Health, Tel Aviv Sourasky Medical Center, and Head of Division of Obstetrics and Gynecology, Faculty of Medicine, Tel Aviv University, Israel

REVIEWS OF PREVIOUS EDITIONSA comprehensive and detailed review of all aspects of management … an excellent reference book and a highly authoritative tome on an increasingly common condition. (Glycosmedia)An excellent job … presenting evidence-based guidance. ... the international perspective is interesting and can add insight.(Doody’s Book Reviews)An excellent general resource ... well-suited for the trainee, particularly in obstetrics, who will care for the pregnant woman with diabetes and her offspring. (New England Journal of Medicine)An excellent resource for all clinicians caring for pregnant women with diabetes. I commend this textbook to any craving a fresh look at an old problem. (Diabetologia)

• In Memoriam: Oded Langer† by Yariv Yogev. Honoring Lois Jovanovič (1947–2018) by Alejandra de Leiva-Pérez and Alberto de Leiva-Hidalgo. Preface. List of Contributors. 1 Prologue: Maternal Medicine Meets Fetal Medicine: Merging the Legacies and Hypotheses. 2 History of Diabetic Pregnancy. 3 Epidemiology of Gestational Diabetes Mellitus. 4 The Great Obstetric Syndromes: The Roots of Disease. 5 Metabolism in Normal and in Diabetic Pregnancy. 6 Nutrient Delivery and Metabolism in the Fetus. 7 Pathogenesis of Gestational Diabetes Mellitus. 8 Autoimmunity in Gestational Diabetes Mellitus. 9 The Placenta in Diabetic Pregnancy. 10 Gestational Diabetes Mellitus: The Consequences of Not Treating. 11 Implications of Diabetic Pregnancy: The Offspring. 12 Short-Term Implications: The Neonate. 13 Implications of Diabetic Pregnancy: The Mother. 14 Gestational Diabetes Mellitus, Obesity and Pregnancy Outcomes. 15 Hypertensive Disorders and Diabetic Pregnancy. 16 Fetal Congenital Malformations in Diabetic Pregnancy. 17 Post-Implantation Diabetic Embryopathy. 18 Congenital Malformations in Diabetic Pregnancy: Prevalence and Types. 19 Reproduction and Its Impact on Health and Disease. 20 Prediction and Prevention of Gestational Diabetes Mellitus. 21 Inositols and Prevention of Gestational Diabetes Mellitus. 22 The Multiomics Approach to Diabetes in Pregnancy. 23 The Role of Bariatric Surgery in Obese Women Planning Pregnancy. 24 The Role of Glucagon-Like Peptide-1 (GLP-1) in Women with Obesity Planning Pregnancy. 25 Diagnosis of Gestational Diabetes Mellitus. 26 Glucose Intolerance in Pregnancy: A Window to Mother and Offspring Future Cardio-Metabolic Risk. 27 Ideal Weight Gain in Pregnancy with Diabetes. 28 Glycemic Goals in Diabetic Pregnancy and Defining "Good Control": Maternal and Fetal Perspective. 29 Medical Nutritional Therapy for Gestational Diabetes Mellitus. 30 Insulin Therapy in Pregnancy. 31 Use of Non-Insulin Antihyperglycemic Drugs in Relation to Pregnancy. 32 Continuous Subcutaneous Insulin Infusion and Continuous Glucose Monitoring in Pregnancy. 33 Periconceptional Assessment in Diabetic Women Planning Pregnancy. 34 Early Pregnancy Loss and Perinatal Mortality. 35 Fetal Surveillance in Diabetic Pregnancies. 36 Timing and Mode of Delivery in Diabetic Pregnancy. 37 Management of the Macrosomic Fetus: Can Fetal Macrosomia Be Predicted and Prevented? 38 Gestational Diabetes in Twin Pregnancies. 39 Fetal Growth Restriction in Diabetic Pregnancies. 40 Diabetes, Obesity, Hypertension, and Preterm Birth. 41 Diabetic Retinopathy. 42 Diabetic Kidney Disease. 43 Diabetic Ketoacidosis. 44 Thyroid In Pregnancy. 45 Gestational Diabetes in Lower- and Middle-Income Countries. 46 Managing Diabetic Pregnancy in China. 47 Links between Maternal Health and Noncommunicable Diseases. 48 Diabetes, Pregnancy, and the Developmental Origins of Health and Disease. 49 Postpartum Management: Mother and Offspring. 50 Non-Invasive Glucose Monitoring. 51 Closed-Loop Insulin Delivery in Type 1 Diabetes Pregnancy. 52 Epilogue: Maternal Fetal Medicine Meets Femtech while Digitalizing Pregnancy Management: Present and Future. Index.