Purification of Biotechnological Products

A Focus on Industrial Applications

AvAdalberto Pessoa Jr,Beatriz Vahan Kilikian

Häftad, Engelska, 2025

Del i serien Drugs and the Pharmaceutical Sciences

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Beskrivning

This outstanding text focuses on providing professionals and students working in the pharmaceutical and biotechnology field with the background necessary for developing of a product or process and with the necessary rigor required by federal regulatory agencies in the pharmaceutical industry. The material will enable teachers, lecturers and professors in biotechnology to prepare courses on basic concepts and applications for the purification of biotechnological products of industrial interest. These can be applied in practice, for example, with projects on purification development on an industrial scale or useful unit operations for the development of bioproducts of commercial interest.Features:Purification and development of new bioproducts and improvement of those being producedProvides a background and concepts on the purification of biomolecules and with an industrial perspectiveIt allows professionals to understand the entire process of developing a biopharmaceutical or bio-food, from bench to industry in biotechnology; one of the fastest-growing sectors of the economyIt promotes the dissemination of information in a didactic way which is of paramount importance for interdisciplinary fieldsIt enables the reader to follow step-by-step stages of the development of a new biopharmaceutical, and allows the optimization of existing processes

Produktinformation

Utgivningsdatum:2025-08-29
Mått:178 x 254 x 29 mm
Vikt:1 020 g
Format:Häftad
Språk:Engelska
Serie:Drugs and the Pharmaceutical Sciences
Antal sidor:522
Förlag:Taylor & Francis Ltd
ISBN:9781032726809

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Mer om författaren

Dr. Adalberto Pessoa Jr., Full professor at the School of Pharmaceutical Sciences, Biochemical-Pharmaceutical Technology Department, of the University of São Paulo and Visiting Professor at King’s College London, Institute of Pharmaceutical Science. He has experience in fermentation technology and in the purification processes of biotechnological products of interest to the pharmaceutical and food industries.Dr. Beatriz Vahan Kilikian, nowadays retired, she was Associate Professor at the Polytechnic School of the University of São Paulo, from 1983 to 2012. She has experience in microrganisms cultivation and in the purification processes of biotechnological products of interest to the pharmaceutical, chemical and food industries.Dr. Paul Frederick Long Full Professor of Biotechnology at King's College London and Visiting International Research Professor at the University of São Paulo. Prof Long is a microbiologist by training and his research uses a combination of bioinformatics, laboratory and field studies to discover new medicines from nature, particularly from the marine environment.

Innehållsförteckning

Chapter 1 Introduction Chapter 2 Purification processes: analytical methods and enzyme stability Chapter 3 Cell Disruption Chapter 4 Filtration and Centrifugation Chapter 5 Membrane Separation Processes Chapter 6 Protein Precipitation Chapter 7 Liquid-liquid extraction in aqueous two-phase systems Chapter 8 Introduction to chromatography Chapter 9 Size exclusion chromatography Chapter 10 Iion Exchange chromatography Chapter 11 Hydrophobic interaction chromatography Chapter 12 Affinity Chromatography Chapter 13 Adsorption chromatography in monolithic columns Chapter 14 Chromatography: expanded bed adsorption (EBA)Chapter 15 Continuous Chromatography using a Simulated Moving Bed System Chapter 16 Chromatography scale-up Chapter 17 Crystallization Chapter 18 Distillation Chapter 19 Plasmid Purification Chapter 20 Purification of monoclonal antibodies Chapter 21 Peptides of biotechnological interest: general concepts, production, purification and chemical characterization Chapter 22 Integration of steps in the production of biotechnological products