Inbunden, Engelska, 2027

Management of Metabolic and Associated Disorders

Av Vaishali Patil, Saroj M. Verma, Sangeeta Shukla, Vannajan Lee

1553 kr

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Beskrivning

This book provides a comprehensive overview of pathophysiological mechanisms and therapeutic frontiers of metabolic and associated disorders. Significant research efforts focus on understanding the key pathways related to metabolism and their role as therapeutic targets to control it and the associated diseases which may be chronic, debilitating and lethal. For the management of diabetes/dyslipidemia/metabolic syndrome/etc. the therapeutic interventions target improving insulin sensitivity, restoration of metabolic homeostasis, reduce cardiovascular and hepatic risks.The book chapters present a foundational overview of metabolic dysfunction, systematically elucidating the co-morbid associations between systemic metabolic failure and cardiovascular and neurodegenerative complications. The text discusses key regulatory pathways and critical molecular targets of metabolic diseases, including brain-derived neurotrophic factor (BDNF), receptor for advanced glycation endproducts (RAGE), dipeptidyl peptidase-4 (DPP-4), pancreatic and deuodenal homeobox 1 (PDX1), proprotein convertase subtilisin/kexin type 9 (PCSK9), and galectin-3, emphasizing their role in the disease progression and their significance in the development of therapeutic interventions.The book further addresses chromenone scaffolds, natural product–derived compounds mainly PPAR modulators, and recent advances in synthetic chemistry for anti-obesity drug development. Protective role of antioxidants in reduction of hyperglycemia-induced oxidative stress helps to lower the risk of vascular complications is provided. Dedicated chapters on diabetes associated complications like diabetic foot ulcer which is a serious complication with neuropathy and/or peripheral artery disease discusses its management. Some chapters also focus on the interconnection between diabetes and obesity, and strategies to improve disease control and therapeutic access along with lifestyle modification which is the primary foundation. The concluding sections focus on precision medicine, artificial intelligence-mediated drug discovery, in silico drug design, and future treatment directions.Key PointsExplores fundamental molecular pathways and the mechanical basis of diabetes, dementia, and cardiovascular complications.Examines targeted therapeutic regulators including PDX1, PCSK9, DPP-4, and the role of galectin-3 in metabolic dysfunction.Analyzes diverse pharmacological approaches, from synthetic anti-obesity drugs and chromenone scaffolds to natural PPAR modulators.Highlights clinical advancements in the management of diabetic foot ulcers and the systemic interconnection between obesity and diabetes.Explores precision medicine, in silico drug design, and AI-mediated therapeutic development for next-generation metabolic treatments.

Produktinformation

Utgivningsdatum: 2027-04-30
Mått: 178 x 254 x undefined mm
Format: Inbunden
Språk: Engelska
Antal sidor: 304
Förlag: Taylor & Francis Ltd
ISBN: 9781041355151

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Mer om författaren

Dr. Vaishali Manikrao Patil is working as Professor (Associate) and Principal/Head at Charak School of Pharmacy, Chaudhary Charan Singh University, Meerut, India. She has >20 years of academic and industrial experience including Visiting Professor at Faculty of Pharmaceutical Sciences, UCSI University, Kuala Lumpur, Malaysia. Her research interest is in Computer-aided drug design and synthesis of biologically active small heterocyclic molecules. She has also published research papers in the peer-reviewed journals and authored numerous books and book chapters published by Springer Verlag, Heidelberg; CRC Press, Taylor and Francis Group; Nova Science Publishers, USA; and Elsevier (Academic Press). She has delivered several lectures on application of rational drug design across the world. She has been conferred with various prestigious awards notably, Dr. A.P.J. Abdul Kalam Technical University Best Teacher Award and has received research grants from Government organization for her work. She is community member of American Chemical Society and life member of APTI-India. She is Editorial Board Member of indexed journals viz. Anti-Infective Agents and Coronaviruses.Dr. Saroj Verma is an accomplished academician and researcher with 15 years of experience in pharmaceutical sciences, currently serving as an Associate Professor in Pharmaceutical Chemistry at K.R. Mangalam University, Gurugram. A DST-INSPIRE fellow and Gold Medalist, she earned her Ph.D. from CSIR-CDRI, Lucknow, focusing on target-based drug design and discovery. With 24 peer-reviewed publications in prestigious journals like Drug Discovery Today and the Journal of Chemical Information and Modeling, her research has significantly contributed to drug-target interaction analysis, molecular docking, QSAR studies, and protein informatics. As a scientific advisory member for a WHO-assigned project, she participated in the 2024 Epidemic and Pandemic Preparedness project. Her contributions extend beyond research to curriculum development, institutional leadership, and mentoring, making her a distinguished expert in pharmaceutical education and drug discoveryProf. Sangeeta Shukla is a Professor of Zoology with > 45 years of academic and research experience. Currently Prof. Shukla is serving as the Vice-Chancellor of Chaudhary Charan Singh University, Meerut. Prof. Shukla’s major areas of research are biochemical pharmacology, reproductive biology, and toxicology. She has been awarded fellowship from Welcome Trust, Indo-French Government Fellowship UK and many others. Prof. Shukla has published >200 papers with h-index > 40. She has also edited book and contributed chapters in books. She has held various administration positions including Vice-Chancellor of Jiwaji University, Gwalior. In recognition of her efforts, she held international positions as Vice president for Asian Continent of International Centers for Trace Element Study for UNESCO, France including Council Member of ISTERH. She has completed >25 major research projects and supervised > 20 doctoral theses and many dissertations of M. Phil and M.Sc. students.Prof. Vannajan S. Lee is a renowned researcher specializing in molecular modeling and simulations, dedicated to advancing sustainable development goals (SDGs). With a BSc in Chemistry from Chiang Mai University, Thailand (1994), and a PhD in Pharmaceutical Sciences and Physical Chemistry from the University of Missouri-Kansas City, USA (2001) supported by a prestigious scholarship from the Institute of Promotion and Development Science and Technology Project in Thailand, she has established herself as a prominent figure in her field. Dr. Lee's exceptional contributions were recognized with the 2023 UNESCO Woman of Influence for Science and Technology award at the 1st International Congress for the Women of Influence (ICFWI) in Tehran, Iran. Her expertise lies in molecular modeling and simulations, including Molecular Dynamics, Monte Carlo Simulations, and Quantum Mechanics. She applies these techniques to biomolecular and material design, driving significant contributions to sustainable development. Recently, she co-founded Qubios, an initiative under the Universiti Malaya Deep Technology Start-up Program in 2024, which explores the potential of quantum data and computing in cancer research.

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