Olli Miettinen was born in Piikkiö, Finland on 31 July 1936. He obtained his MD from the University of Helsinki and the MPH and PhD degrees from the University of Minnesota. He was Professor of Epidemiology and Biostatistics at Harvard School of Public Health from 1974 to 1986, and has been a Professor in the Department of Epidemiology, Biostatistics, and Occupational Health and in the Department of Medicine of the Faculty of Medicine at McGill University since 1985. He is the author of 3 textbooks and a veteran of extensive teaching internationally.Albert Hofman, is the Stephen B. Kay Family Professor of Public Health and Clinical Epidemiology and Chair, Department of Epidemiology at the Harvard T.H. Chan School of Public Health. Dr. Hofman received an MD in 1976 from the University of Groningen, and a PhD in 1983 from the Erasmus University Rotterdam. He was appointed in 1981 as an Assistant Professor at the Erasmus University Medical School and was promoted to Associate Professor in 1984. Since 1988 he has been full Professor and Chair in the Department of Epidemiology at the Erasmus Medical Center. In addition, Dr. Hofman has been a Science Director at the Netherlands Institute for Health Sciences since 1992, as well as an adjunct Professor of Epidemiology at our School since 1998, and a Visiting Professor of Clinical Epidemiology since January 2016. Dr. Hofman has an excellent record of teaching, including being the initiator and program director of the Erasmus Summer Program since 1991, and teaching the summer session courses on Fundamentals of Epidemiology and on Study Design in Clinical Epidemiology at Harvard. Johann Steurer is the Director of the Horten Centre for patient oriented research and knowledge transfer. University of Zürich.

• Foreword.- Preface.- Acknowledgements.- Essence of Clinical Medicine.- Essence of Clinical Research.- Clinical Research and Clinical Medicine at present.- Clinical Research Transformative of Clinical Medicine.- Core Concepts of Epidemiology and Epidemiological Research.- The Epidemiological Interface of Gnostic Clinical Research.- The Logistic Regression Model.- Statistics from the Model’s Fitting to Gnostic Data.- The Types of Diagnostic Challenge and Needs for Knowledge.- Harvesting Experts’ Diagnostic Probability Estimates.- Objects Design for a Diagnostic Probability Study.- Methods Design for a Diagnostic Probability Study.- The Bayes’ Theorem Framework for Diagnostic Research.- Research Focused on Diagnostic Tests.- Introduction to Etiognostic Research.- Objects Design for an Etiognostic Study.- Methods Design for an Etiognostic Study.- Introduction to Prognostic Research.- Example: Research on ‘Hormone Replacement Therapy’.- Prognostic Probability Functions from Clinical-trial Data.- Non-experimental Intervention-prognostic Studies.- Intervention-prognostic Derivative Research.- Theory of Medicine Defining the Essential Missions for Clinical Research.- Theory of Clinical Research  for Its Essential - Gnosis-serving - Missions.- Toward Worldwide Scientific Clinical Medicine.- Glossary.- Appendix 1: What about ‘Machine Learning’?- Appendix 2: On Excellence of Epidemiologic Academia.- Index.

Olli Miettinen was born in Piikkiö, Finland on 31 July 1936. He obtained his MD from the University of Helsinki and the MPH and PhD degrees from the University of Minnesota. He was Professor of Epidemiology and Biostatistics at Harvard School of Public Health from 1974 to 1986, and has been a Professor in the Department of Epidemiology, Biostatistics, and Occupational Health and in the Department of Medicine of the Faculty of Medicine at McGill University since 1985. He is the author of 3 textbooks and a veteran of extensive teaching internationally.Albert Hofman, is the Stephen B. Kay Family Professor of Public Health and Clinical Epidemiology and Chair, Department of Epidemiology at the Harvard T.H. Chan School of Public Health. Dr. Hofman received an MD in 1976 from the University of Groningen, and a PhD in 1983 from the Erasmus University Rotterdam. He was appointed in 1981 as an Assistant Professor at the Erasmus University Medical School and was promoted to Associate Professor in 1984. Since 1988 he has been full Professor and Chair in the Department of Epidemiology at the Erasmus Medical Center. In addition, Dr. Hofman has been a Science Director at the Netherlands Institute for Health Sciences since 1992, as well as an adjunct Professor of Epidemiology at our School since 1998, and a Visiting Professor of Clinical Epidemiology since January 2016. Dr. Hofman has an excellent record of teaching, including being the initiator and program director of the Erasmus Summer Program since 1991, and teaching the summer session courses on Fundamentals of Epidemiology and on Study Design in Clinical Epidemiology at Harvard. Johann Steurer is the Director of the Horten Centre for patient oriented research and knowledge transfer. University of Zürich.

• Foreword.- Preface.- Acknowledgements.- Essence of Clinical Medicine.- Essence of Clinical Research.- Clinical Research and Clinical Medicine at present.- Clinical Research Transformative of Clinical Medicine.- Core Concepts of Epidemiology and Epidemiological Research.- The Epidemiological Interface of Gnostic Clinical Research.- The Logistic Regression Model.- Statistics from the Model’s Fitting to Gnostic Data.- The Types of Diagnostic Challenge and Needs for Knowledge.- Harvesting Experts’ Diagnostic Probability Estimates.- Objects Design for a Diagnostic Probability Study.- Methods Design for a Diagnostic Probability Study.- The Bayes’ Theorem Framework for Diagnostic Research.- Research Focused on Diagnostic Tests.- Introduction to Etiognostic Research.- Objects Design for an Etiognostic Study.- Methods Design for an Etiognostic Study.- Introduction to Prognostic Research.- Example: Research on ‘Hormone Replacement Therapy’.- Prognostic Probability Functions from Clinical-trial Data.- Non-experimental Intervention-prognostic Studies.- Intervention-prognostic Derivative Research.- Theory of Medicine Defining the Essential Missions for Clinical Research.- Theory of Clinical Research  for Its Essential - Gnosis-serving - Missions.- Toward Worldwide Scientific Clinical Medicine.- Glossary.- Appendix 1: What about ‘Machine Learning’?- Appendix 2: On Excellence of Epidemiologic Academia.- Index.