Dr. Jian Zhang is Professor at Shanghai Jiao Tong University School of Medicine, Shanghai, China; Dr. Ruth Nussinov is Professor in the Section of Computational Structural Biology, Cancer and Inflammation Program, National Cancer Institute, USA

• Chapter 1. Allostery in Drug Development.- Chapter 2. Dynamic Protein Allosteric Regulation and Disease.- Chapter 3. Protein Allostery in Rational Drug Design.- Chapter 4. Progress in Allosteric Database.- Chapter 5. Correlation between Allosteric and Orthosteric Sites.- Chapter 6. Characteristics of Allosteric Proteins, Sites and Modulators.- Chapter 7. Advances in the Computational Identification of Allosteric Sites and Pathways in Proteins.- Chapter 8. Advances in NMR Methods to Identify Allosteric Sites and Allosteric Ligands.- Chapter 9. Interrogating Regulatory Mechanisms in Signal-ling Proteins by Allosteric Inhibitors and Activators: A Dynamic View through the Lens of Residue Interaction Network.- Chapter 10. GPCR Allosteric Modulator Discovery.- Chapter 11. Allosteric Small-Molecule Serine/Threonine Kinase Inhibitors.- Chapter 12. Allosteric regulation of protein kinases downstream of PI3-kinase signaling. Chapter 13. Allosteric Modulators of Protein-Protein Interactions (PPIs).- Chapter 14. Allosteric Modulation of Intrinsically Disordered Proteins.- Chapter 15. Engineering Allostery into Proteins.

Dr. Jian Zhang is Professor at Shanghai Jiao Tong University School of Medicine, Shanghai, China; Dr. Ruth Nussinov is Professor in the Section of Computational Structural Biology, Cancer and Inflammation Program, National Cancer Institute, USA

• Chapter 1. Allostery in Drug Development.- Chapter 2. Dynamic Protein Allosteric Regulation and Disease.- Chapter 3. Protein Allostery in Rational Drug Design.- Chapter 4. Progress in Allosteric Database.- Chapter 5. Correlation between Allosteric and Orthosteric Sites.- Chapter 6. Characteristics of Allosteric Proteins, Sites and Modulators.- Chapter 7. Advances in the Computational Identification of Allosteric Sites and Pathways in Proteins.- Chapter 8. Advances in NMR Methods to Identify Allosteric Sites and Allosteric Ligands.- Chapter 9. Interrogating Regulatory Mechanisms in Signal-ling Proteins by Allosteric Inhibitors and Activators: A Dynamic View through the Lens of Residue Interaction Network.- Chapter 10. GPCR Allosteric Modulator Discovery.- Chapter 11. Allosteric Small-Molecule Serine/Threonine Kinase Inhibitors.- Chapter 12. Allosteric regulation of protein kinases downstream of PI3-kinase signaling. Chapter 13. Allosteric Modulators of Protein-Protein Interactions (PPIs).- Chapter 14. Allosteric Modulation of Intrinsically Disordered Proteins.- Chapter 15. Engineering Allostery into Proteins.

Dr. Jian Zhang is Professor at Shanghai Jiao Tong University School of Medicine, Shanghai, China; Dr. Ruth Nussinov is Professor in the Section of Computational Structural Biology, Cancer and Inflammation Program, National Cancer Institute, USA

• Chapter 1. Allostery in Drug Development.- Chapter 2. Dynamic Protein Allosteric Regulation and Disease.- Chapter 3. Protein Allostery in Rational Drug Design.- Chapter 4. Progress in Allosteric Database.- Chapter 5. Correlation between Allosteric and Orthosteric Sites.- Chapter 6. Characteristics of Allosteric Proteins, Sites and Modulators.- Chapter 7. Advances in the Computational Identification of Allosteric Sites and Pathways in Proteins.- Chapter 8. Advances in NMR Methods to Identify Allosteric Sites and Allosteric Ligands.- Chapter 9. Interrogating Regulatory Mechanisms in Signal-ling Proteins by Allosteric Inhibitors and Activators: A Dynamic View through the Lens of Residue Interaction Network.- Chapter 10. GPCR Allosteric Modulator Discovery.- Chapter 11. Allosteric Small-Molecule Serine/Threonine Kinase Inhibitors.- Chapter 12. Allosteric regulation of protein kinases downstream of PI3-kinase signaling. Chapter 13. Allosteric Modulators of Protein-Protein Interactions (PPIs).- Chapter 14. Allosteric Modulation of Intrinsically Disordered Proteins.- Chapter 15. Engineering Allostery into Proteins.