Pasquale Arpaia

Non-Invasive Monitoring of Transdermal Drug Delivery

Inbunden, Engelska, 2022

2 088 kr

Skickas inom 10-15 vardagar

The book presents an innovative technology based on injection of a very weak current to trace the quantity of a drug carried immediately after the administration. The book makes the reader familiar with the technology, from the conception through the design of the instrument, up to the preliminary clinical applications. In the first chapter, the method of transdermal drug delivery and the use of impedance spectroscopy in the dermatological field are presented. The second chapter describes a screening measurement campaign aimed at proving the feasibility of the assessment method and identifying the bandwidth of interest. The prototyping, validation and characterization of an instrument to measure the amount of drug delivered (DUSM: Drug Under Skin Meter) are presented in chapter three. In the fourth chapter three experimental campaigns, based on the electrical analysis of the biological tissue behavior due to the drug delivery, are reported: (i) laboratory emulation on eggplants, (ii) ex-vivo tests on pig ears, and finally (iii) in-vivo tests on human volunteers. In the fifth chapter a behavioral model, based on Finite Elements and Partial Differential Equation, of an impedance-based measurement system for assessing the drug released under the skin, during transdermal delivering, is proposed. The last chapter is dedicated to present a campaign in order to prove the suitability for insulin therapy applications. This book is intended for biomedical engineers, biomedical engineering students, operators working in the field of biomedical instrumentation, biotechnologists, and technicians of transdermal vehiculation.

Non-Invasive Monitoring of Transdermal Drug Delivery

AvPasquale Arpaia,Umberto Cesarom. fl.

Häftad, Engelska, 2024

733 kr

Skickas inom 10-15 vardagar

The book presents an innovative technology based on injection of a very weak current to trace the quantity of a drug carried immediately after the administration. The book makes the reader familiar with the technology, from the conception through the design of the instrument, up to the preliminary clinical applications. In the first chapter, the method of transdermal drug delivery and the use of impedance spectroscopy in the dermatological field are presented. The second chapter describes a screening measurement campaign aimed at proving the feasibility of the assessment method and identifying the bandwidth of interest. The prototyping, validation and characterization of an instrument to measure the amount of drug delivered (DUSM: Drug Under Skin Meter) are presented in chapter three. In the fourth chapter three experimental campaigns, based on the electrical analysis of the biological tissue behavior due to the drug delivery, are reported: (i) laboratory emulation on eggplants, (ii) ex-vivo tests on pig ears, and finally (iii) in-vivo tests on human volunteers. In the fifth chapter a behavioral model, based on Finite Elements and Partial Differential Equation, of an impedance-based measurement system for assessing the drug released under the skin, during transdermal delivering, is proposed. The last chapter is dedicated to present a campaign in order to prove the suitability for insulin therapy applications. This book is intended for biomedical engineers, biomedical engineering students, operators working in the field of biomedical instrumentation, biotechnologists, and technicians of transdermal vehiculation.

Wearable Brain-Computer Interfaces

Prototyping EEG-Based Instruments for Monitoring and Control

AvPasquale Arpaia,Antonio Espositom. fl.

Inbunden, Engelska, 2023

2 012 kr

Skickas inom 10-15 vardagar

This book presents a complete overview of the main EEG-based Brain-Computer Interface (BCI) paradigms and the related practical solutions for their design, prototyping, and testing. Readers will explore active, reactive, and passive BCI paradigms, with an emphasis on the operation for developing solutions, addressing the need for customization.Readers will familiarize themselves with the main steps for the realization of low-cost wearable BCIs which include: identification of the most suitable neuro signals for a specific application; definition of the hardware, firmware, and software, with a focus on wearable, non-invasive, and low-cost solutions; development of algorithms for data processing and classification; and, lastly, experimental campaigns for the validation of the prototyped solutions. BCI systems based on electroencephalography (EEG) are investigated and a complete overview of all BCI paradigms is offered. The aim of this book is to drive the reader, from the beginning to the end, along a research-and-development process of a working BCI prototype.This book is a guide for designers, biomedical engineers, students, biotechnologists, and those in the biomedical instrumentation field that would like to conceive, design, prototype, and test an innovative low-cost wearable EEG-based BCI.

Wearable Brain-Computer Interfaces

Prototyping EEG-Based Instruments for Monitoring and Control

AvPasquale Arpaia,Antonio Espositom. fl.

Häftad, Engelska, 2025

691 kr

Skickas inom 10-15 vardagar

This book presents a complete overview of the main EEG-based Brain-Computer Interface (BCI) paradigms and the related practical solutions for their design, prototyping, and testing. Readers will explore active, reactive, and passive BCI paradigms, with an emphasis on the operation for developing solutions, addressing the need for customization.Readers will familiarize themselves with the main steps for the realization of low-cost wearable BCIs which include: identification of the most suitable neuro signals for a specific application; definition of the hardware, firmware, and software, with a focus on wearable, non-invasive, and low-cost solutions; development of algorithms for data processing and classification; and, lastly, experimental campaigns for the validation of the prototyped solutions. BCI systems based on electroencephalography (EEG) are investigated and a complete overview of all BCI paradigms is offered. The aim of this book is to drive the reader, from the beginning to the end, along a research-and-development process of a working BCI prototype.This book is a guide for designers, biomedical engineers, students, biotechnologists, and those in the biomedical instrumentation field that would like to conceive, design, prototype, and test an innovative low-cost wearable EEG-based BCI.

High-Repeatability Data Acquisition Systems for Pulsed Power Converters

AvPasquale Arpaia,Carlo Baccigalupim. fl.

Häftad, Engelska, 2017

504 kr

Skickas inom 3-6 vardagar

Addresses several issues related to the metrological characterization of high-performance pulsed power converters. Initially, a background and state-of-the-art on measurement systems for high-performance power converter are presented. In industrial applications of power converters metrology, specifications are often given in terms of worst-case uncertainty (WCU). Therefore, an analytical model for predicting the WCU of a measurement system is discussed and detailed for instruments affected by Gaussian noise. The authors discuss the study and design of a reference acquisition system for characterizing high-power pulses as well as the design of an on-line acquisition system for controlling the power converter. The book continues with numerical results obtained in simulation for the three main topics, which demonstrate the effectiveness of the proposals. Finally, the experimental results of a case study, carried out in the framework of the Compact Linear Collider (CLIC) at CERN, are reported. To meet CLIC requirements the two systems were designed to be ultra-low noise and are demonstrated to be repeatable in the order of few tens of parts per million (ppm).

Cryogenic Systems

Advanced Monitoring, Fault Diagnostics, and Predictive Maintenance

AvPasquale Arpaia,Mario Gironem. fl.

Häftad, Engelska, 2017

504 kr

Skickas inom 3-6 vardagar

Advanced methods and techniques of monitoring, fault diagnostics, and predictive maintenance for cryogenics are illustrated in this boo.In Part I: Background, mainstreams in the related research are reviewed. In Part II: Methods, for monitoring helium distribution and consumption in cryogenic systems for particle accelerators, a virtual flowmeter is presented. Then, for fault diagnostics, two methods, for fault detection on a compressor, and for distributed diagnostics based on a micro-genetic algorithm, are described.Finally, for predictive maintenance, a metaheuristic optimization scheduling algorithm is illustrated. In Part III of Application examples, several practical case studies are described for highlighting the application of the previous methods to cryogenics of particle accelerators at CERN.

Del 12980 - Lecture Notes in Computer Science

Augmented Reality, Virtual Reality, and Computer Graphics

8th International Conference, AVR 2021, Virtual Event, September 7–10, 2021, Proceedings

AvLucio Tommaso De Paolis,Pasquale Arpaiam. fl.

Häftad, Engelska, 2021

1 422 kr

Skickas inom 10-15 vardagar

This book constitutes the refereed proceedings of the 8th International Conference on Augmented Reality, Virtual Reality, and Computer Graphics, AVR 2021, held in Italy, in September 2021.

Del 13445 - Lecture Notes in Computer Science

Pasquale Arpaia - Böcker

Non-Invasive Monitoring of Transdermal Drug Delivery

Non-Invasive Monitoring of Transdermal Drug Delivery

Wearable Brain-Computer Interfaces

Wearable Brain-Computer Interfaces

High-Repeatability Data Acquisition Systems for Pulsed Power Converters

Cryogenic Systems

Augmented Reality, Virtual Reality, and Computer Graphics

Extended Reality

Extended Reality

Extended Reality

Extended Reality

Extended Reality

Extended Reality

Extended Reality

Extended Reality

Extended Reality

Extended Reality

Extended Reality

Extended Reality

Extended Reality

Extended Reality

Extended Reality