Dr. Wael Mohamed, BSc, MMSc, MD, PhD, FAAS, is Professor, Basic Medical Science Department at the International Islamic University Malaysia (IIUM). He specializes in translational brain research and the development of novel treatments for Alzheimer’s Disease and Parkinson’s Disease.

• Section I. Neurodegeneration – Pathophysiology and Unmet Needs1. The global burden of neurodegenerative disorders: From Alzheimer’s to ALS2. Limitations of current models: Why zebrafish? .3. Emerging biomarkers and diagnostic challengesSection II. Zebrafish Biology and Methodological Innovations4. Zebrafish neuroanatomy: A window into conserved and divergent pathways5. Genetic tools: CRISPR, transgenics, and disease variants6. High-throughput screening and AI-driven phenotypingSection III. Modelling Specific Neurodegenerative Disorders7. Parkinson’s Disease: From α-synuclein to dopaminergic circuitry8. Toxin-induced PD models: MPTP, 6-OHDA, and rotenone protocols9. Alzheimer’s Disease: Amyloid-β, tau, and cognitive decline10. Huntington’s Disease: Tracking PolyQ aggregation in real time11. ALS and motor neuron degeneration: Lessons from zebrafish12. Cognitive decline using zebrafish modelSection IV. Uncharted Territories and Translational Insights13. The gut-brain axis: Zebrafish insights into microbiome interactions14. Non-motor symptoms: Sleep, anxiety, and metabolic dysregulation15. From bench to bedside: Case studies in drug repurposing16. Mitochondrial dysfunction and the PINK1-Parkin pathway in zebrafish17. Neuroinflammation in PD: Microglial activation and cytokine profiling18. Neuronal differentiation in zebrafish embryoSection V. Translational Applications and Innovations19. Biomarker discover: Omics approaches in zebrafish Parkinson’s Disease models20. Stem cell therapy: Dopaminergic neuron regeneration in zebrafish21. AI-driven behavioral analysis: Quantifying motor and cognitive decline22. From zebrafish to clinic: Case studies in LRRK2 inhibitor development23. Behavioral assessment in zebrafish24. Bridging the gap: Practical steps to adopting zebrafish models in neurodegeneration studiesSection VI. Comparative and Ethical Perspectives25. Zebrafish versus mammalian models: Strengths, limitations, and synergies26. Ethical challenges in zebrafish research: Balancing innovation and welfare

Dr. Wael Mohamed, BSc, MMSc, MD, PhD, FAAS, is Professor, Basic Medical Science Department at the International Islamic University Malaysia (IIUM). He specializes in translational brain research and the development of novel treatments for Alzheimer’s Disease and Parkinson’s Disease.

• Section I. Neurodegeneration – Pathophysiology and Unmet Needs1. The global burden of neurodegenerative disorders: From Alzheimer’s to ALS2. Limitations of current models: Why zebrafish? .3. Emerging biomarkers and diagnostic challengesSection II. Zebrafish Biology and Methodological Innovations4. Zebrafish neuroanatomy: A window into conserved and divergent pathways5. Genetic tools: CRISPR, transgenics, and disease variants6. High-throughput screening and AI-driven phenotypingSection III. Modelling Specific Neurodegenerative Disorders7. Parkinson’s Disease: From α-synuclein to dopaminergic circuitry8. Toxin-induced PD models: MPTP, 6-OHDA, and rotenone protocols9. Alzheimer’s Disease: Amyloid-β, tau, and cognitive decline10. Huntington’s Disease: Tracking PolyQ aggregation in real time11. ALS and motor neuron degeneration: Lessons from zebrafish12. Cognitive decline using zebrafish modelSection IV. Uncharted Territories and Translational Insights13. The gut-brain axis: Zebrafish insights into microbiome interactions14. Non-motor symptoms: Sleep, anxiety, and metabolic dysregulation15. From bench to bedside: Case studies in drug repurposing16. Mitochondrial dysfunction and the PINK1-Parkin pathway in zebrafish17. Neuroinflammation in PD: Microglial activation and cytokine profiling18. Neuronal differentiation in zebrafish embryoSection V. Translational Applications and Innovations19. Biomarker discover: Omics approaches in zebrafish Parkinson’s Disease models20. Stem cell therapy: Dopaminergic neuron regeneration in zebrafish21. AI-driven behavioral analysis: Quantifying motor and cognitive decline22. From zebrafish to clinic: Case studies in LRRK2 inhibitor development23. Behavioral assessment in zebrafish24. Bridging the gap: Practical steps to adopting zebrafish models in neurodegeneration studiesSection VI. Comparative and Ethical Perspectives25. Zebrafish versus mammalian models: Strengths, limitations, and synergies26. Ethical challenges in zebrafish research: Balancing innovation and welfare

Dr. Wael Mohamed, BSc, MMSc, MD, PhD, FAAS, is Professor, Basic Medical Science Department at the International Islamic University Malaysia (IIUM). He specializes in translational brain research and the development of novel treatments for Alzheimer’s Disease and Parkinson’s Disease.

• Section I. Neurodegeneration – Pathophysiology and Unmet Needs1. The global burden of neurodegenerative disorders: From Alzheimer’s to ALS2. Limitations of current models: Why zebrafish? .3. Emerging biomarkers and diagnostic challengesSection II. Zebrafish Biology and Methodological Innovations4. Zebrafish neuroanatomy: A window into conserved and divergent pathways5. Genetic tools: CRISPR, transgenics, and disease variants6. High-throughput screening and AI-driven phenotypingSection III. Modelling Specific Neurodegenerative Disorders7. Parkinson’s Disease: From α-synuclein to dopaminergic circuitry8. Toxin-induced PD models: MPTP, 6-OHDA, and rotenone protocols9. Alzheimer’s Disease: Amyloid-β, tau, and cognitive decline10. Huntington’s Disease: Tracking PolyQ aggregation in real time11. ALS and motor neuron degeneration: Lessons from zebrafish12. Cognitive decline using zebrafish modelSection IV. Uncharted Territories and Translational Insights13. The gut-brain axis: Zebrafish insights into microbiome interactions14. Non-motor symptoms: Sleep, anxiety, and metabolic dysregulation15. From bench to bedside: Case studies in drug repurposing16. Mitochondrial dysfunction and the PINK1-Parkin pathway in zebrafish17. Neuroinflammation in PD: Microglial activation and cytokine profiling18. Neuronal differentiation in zebrafish embryoSection V. Translational Applications and Innovations19. Biomarker discover: Omics approaches in zebrafish Parkinson’s Disease models20. Stem cell therapy: Dopaminergic neuron regeneration in zebrafish21. AI-driven behavioral analysis: Quantifying motor and cognitive decline22. From zebrafish to clinic: Case studies in LRRK2 inhibitor development23. Behavioral assessment in zebrafish24. Bridging the gap: Practical steps to adopting zebrafish models in neurodegeneration studiesSection VI. Comparative and Ethical Perspectives25. Zebrafish versus mammalian models: Strengths, limitations, and synergies26. Ethical challenges in zebrafish research: Balancing innovation and welfare