Audrey R. Chapman is director of the Science and Human Rights Program and senior associate for ethics in the Dialogue on Science, Ethics, and Religion at the American Association for the Advancement of Science. Mark S. Frankel is the director of the Scientific Freedom, Responsibility, and Law Program at American Association for the Advancement of Science.

With so much heat and little light often shed on the debates around developments in human genetic engineering, this collection of 20 essays is much overdue, and tremendously informative.—Conscience

• Framing the issues, Audrey R. Chapman and Mark S. Frankel; Germ line dancing - definitional considerations for policy makers, Eric Juengst and Erik Parens; Approaches to gene transfer to the mammalian germ line, Theodore Friedmann; Scientific methodologies to facilitate inheritable genetic modifications in humans, Bhavani Pathak; Germ-line modification in clinical medicine - is there a case for intentional or unintended germ-line changes?, R. Michael Blaese; Gene repair, genomics, and human germ-line modification, Kenneth Culver; Germ-line gene therapy - can we do it, do we need it, where do we start, and where might it lead?, Christopher H. Evans; The moral impasse in human embryo research - bypasses in the making?, John Fletcher; Justice implications of inheritable genetic modifications, Audrey R. Chapman; The hidden eugenic potential of germ-line interventions, Troy Duster; Ethical differences between inheritable genetic modification and embryo selection, Bonnie Steinbock; Human limits - theological perspectives on germ-line modification, Ronald Cole-Turner; The Catholic Church's moral tradition and germ-line intervention, Albert Moraczewski; Uncountable as the stars - inheritable genetic intervention and the human future, a Jewish perspective, Laurie Zoloth-Dorfman; Parental liberty and the right of access to germ-line intervention - a theological appraisal of parental power, Sondra Wheeler; Inheritable genetic modifications - do we owe them to our children?, Pilar N. Ossorio; National policies to oversee inheritable genetic modifications research, Julie Gage-Palmer and Robert Cook-Deegan; Designing tomorrow's children - the right to reproduce and oversight of germ-line interventions, Cynthia Cohen; To market, to market - effects of commerce on cross-generational genetic change, Mark S. Frankel and Michele S. Garfinkel; Recommendations for policy, Mark S. Frankel and Audrey R. Chapman. Appendices: Consent form for participation in a study of inheritable germ-line modification, Julie Gage-Palmer; AAAS report on IGM - major findings, concerns, and recommendations.

Audrey R. Chapman is director of the Science and Human Rights Program and senior associate for ethics in the Dialogue on Science, Ethics, and Religion at the American Association for the Advancement of Science. Mark S. Frankel is the director of the Scientific Freedom, Responsibility, and Law Program at American Association for the Advancement of Science.

With so much heat and little light often shed on the debates around developments in human genetic engineering, this collection of 20 essays is much overdue, and tremendously informative.—Conscience

• Framing the issues, Audrey R. Chapman and Mark S. Frankel; Germ line dancing - definitional considerations for policy makers, Eric Juengst and Erik Parens; Approaches to gene transfer to the mammalian germ line, Theodore Friedmann; Scientific methodologies to facilitate inheritable genetic modifications in humans, Bhavani Pathak; Germ-line modification in clinical medicine - is there a case for intentional or unintended germ-line changes?, R. Michael Blaese; Gene repair, genomics, and human germ-line modification, Kenneth Culver; Germ-line gene therapy - can we do it, do we need it, where do we start, and where might it lead?, Christopher H. Evans; The moral impasse in human embryo research - bypasses in the making?, John Fletcher; Justice implications of inheritable genetic modifications, Audrey R. Chapman; The hidden eugenic potential of germ-line interventions, Troy Duster; Ethical differences between inheritable genetic modification and embryo selection, Bonnie Steinbock; Human limits - theological perspectives on germ-line modification, Ronald Cole-Turner; The Catholic Church's moral tradition and germ-line intervention, Albert Moraczewski; Uncountable as the stars - inheritable genetic intervention and the human future, a Jewish perspective, Laurie Zoloth-Dorfman; Parental liberty and the right of access to germ-line intervention - a theological appraisal of parental power, Sondra Wheeler; Inheritable genetic modifications - do we owe them to our children?, Pilar N. Ossorio; National policies to oversee inheritable genetic modifications research, Julie Gage-Palmer and Robert Cook-Deegan; Designing tomorrow's children - the right to reproduce and oversight of germ-line interventions, Cynthia Cohen; To market, to market - effects of commerce on cross-generational genetic change, Mark S. Frankel and Michele S. Garfinkel; Recommendations for policy, Mark S. Frankel and Audrey R. Chapman. Appendices: Consent form for participation in a study of inheritable germ-line modification, Julie Gage-Palmer; AAAS report on IGM - major findings, concerns, and recommendations.