Synthesis – serie

In The Secrets of Alchemy, Lawrence M. Principe, one of the world's leading authorities on the subject, brings alchemy out of the shadows and restores it to its important place in human history and culture. By surveying what alchemy was and how it began, developed, and overlapped with a range of ideas and pursuits, Principe illuminates the practice. He vividly depicts the place of alchemy during its heyday in early modern Europe, and then explores how alchemy has fit into wider views of the cosmos and humanity, touching on its enduring place in literature, fine art, theater, and religion as well as its recent acceptance as a serious subject of study for historians of science. In addition, he introduces the reader to some of the most fascinating alchemists, such as Zosimos and Basil Valentine, whose lives dot alchemy's long reign from the third century down to the present day.Through his exploration of alchemists and their times, Principe pieces together closely guarded clues from obscure and fragmented texts to reveal alchemy's secrets, and - most exciting for budding alchemists - uses them to recreate many of the most famous recipes in his lab, including those for the "glass of antimony" and "philosophers' tree." This unique approach brings the reader closer to the actual work of alchemy than any other book.

The advent of recombinant DNA technology in the 1970s was a key moment in the history of both biotechnology and the commercialization of academic research. Doogab Yi's The Recombinant University draws us deeply into the academic community in the San Francisco Bay Area, where the technology was developed and adopted as the first major commercial technology for genetic engineering. In doing so, it reveals how research patronage, market forces, and legal developments from the late 1960s through the early 1980s influenced the evolution of the technology and reshaped the moral and scientific life of biomedical researchers. Bay Area scientists, university administrators, and government officials were fascinated by and increasingly engaged in the economic and political opportunities associated with the privatization of academic research. Yi uncovers how the attempts made by Stanford scientists and administrators to demonstrate the relevance of academic research were increasingly mediated by capitalistic conceptions of knowledge, medical innovation, and the public interest.The Recombinant University brings to life the hybrid origin story of biotechnology and the ways the academic culture of science has changed in tandem with the early commercialization of recombinant DNA technology.

After World War II, the US Atomic Energy Commission (AEC) began mass-producing radioisotopes, sending out nearly 64,000 shipments of radioactive materials to scientists and physicians by 1955. Even as the atomic bomb became the focus of Cold War anxiety, radioisotopes represented the government's efforts to harness the power of the atom for peace—advancing medicine, domestic energy, and foreign relations. In Life Atomic, Angela N. H. Creager tells the story of how these radioisotopes, which were simultaneously scientific tools and political icons, transformed biomedicine and ecology. Government-produced radioisotopes provided physicians with new tools for diagnosis and therapy, specifically cancer therapy, and enabled biologists to trace molecular transformations. Yet the government's attempt to present radioisotopes as marvelous dividends of the atomic age was undercut in the 1950s by the fallout debates, as scientists and citizens recognized the hazards of low-level radiation.Creager reveals that growing consciousness of the danger of radioactivity did not reduce the demand for radioisotopes at hospitals and laboratories, but it did change their popular representation from a therapeutic agent to an environmental poison. She then demonstrates how, by the late twentieth century, public fear of radioactivity overshadowed any appreciation of the positive consequences of the AEC's provision of radioisotopes for research and medicine.

What did it mean to be a scientist before the profession itself existed? Jan Golinski finds an answer in the remarkable career of Humphry Davy, the foremost chemist of his day and one of the most distinguished British men of science of the nineteenth century. Originally a country boy from a modest background, Davy was propelled by his scientific accomplishments to a knighthood and the presidency of the Royal Society. An enigmatic figure to his contemporaries, Davy has continued to elude the efforts of biographers to classify him: poet, friend to Coleridge and Wordsworth, author of travel narratives and a book on fishing, chemist and inventor of the miners’ safety lamp. What are we to make of such a man?            In The Experimental Self, Golinski argues that Davy’s life is best understood as a prolonged process of self-experimentation. He follows Davy from his youthful enthusiasm for physiological experiment through his self-fashioning as a man of science in a period when the path to a scientific career was not as well-trodden as it is today. What emerges is a portrait of Davy as a creative fashioner of his own identity through a lifelong series of experiments in selfhood.

In the fall of 1980, Genentech, Inc., a little-known California genetic engineering company, became the overnight darling of Wall Street, raising over $38 million in its initial public stock offering. Lacking marketed products or substantial profit, the firm nonetheless saw its share price escalate from $35 to $89 in the first few minutes of trading, at that point the largest gain in stock market history. Coming at a time of economic recession and declining technological competitiveness in the United States, the event provoked banner headlines and ignited a period of speculative frenzy over biotechnology as a revolutionary means for creating new and better kinds of pharmaceuticals, untold profit, and a possible solution to national economic malaise. Drawing from an unparalleled collection of interviews with early biotech players, Sally Smith Hughes offers the first book-length history of this pioneering company. Hughes provides intimate portraits of the people significant to Genentech's science and business, including co-founders Herbert Boyer and Robert Swanson, and in doing so sheds new light on how personality affects the growth of science.By placing Genentech's founders, followers, opponents, victims, and beneficiaries in context, Hughes also demonstrates how science interacts with commercial and legal interests and university research, and with government regulation, venture capital, and commercial profits. Integrating the scientific, the corporate, the contextual, and the personal, Genentech tells the story of biotechnology as it is not often told, as a risky and improbable entrepreneurial venture that had to overcome a number of powerful forces working against it.

In Inventing Chemistry, historian John C. Powers turns his attention to Herman Boerhaave (1668–1738), a Dutch medical and chemical professor whose work reached a wide, educated audience and became the template for chemical knowledge in the eighteenth century. The primary focus of this study is Boerhaave’s educational philosophy, and Powers traces its development from Boerhaave’s early days as a student in Leiden through his publication of the Elementa chemiae in 1732. Powers reveals how Boerhaave restructured and reinterpreted various practices from diverse chemical traditions (including craft chemistry, Paracelsian medical chemistry, and alchemy), shaping them into a chemical course that conformed to the pedagogical and philosophical norms of Leiden University’s medical faculty. In doing so, Boerhaave gave his chemistry a coherent organizational structure and philosophical foundation and thus transformed an artisanal practice into an academic discipline. Inventing Chemistry is essential reading for historians of chemistry, medicine, and academic life.

In 1968 a team of scientists and engineers from RCA announced the creation of a new form of electronic display that relied upon an obscure set of materials known as liquid crystals. At a time when televisions utilized bulky cathode ray tubes to produce an image, these researchers demonstrated how liquid crystals could electronically control the passage of light. One day, they predicted, liquid crystal displays would find a home in clocks, calculators—and maybe even a television that could hang on the wall.  Half a century later, RCA’s dreams have become a reality, and liquid crystals are the basis of a multibillion-dollar global industry. Yet the company responsible for producing the first LCDs was unable to capitalize upon its invention. In The TVs of Tomorrow, Benjamin Gross explains this contradiction by examining the history of flat-panel display research at RCA from the perspective of the chemists, physicists, electrical engineers, and technicians at the company’s central laboratory in Princeton, New Jersey.  Drawing upon laboratory notebooks, internal reports, and interviews with key participants, Gross reconstructs the development of the LCD and situates it alongside other efforts to create a thin, lightweight replacement for the television picture tube. He shows how RCA researchers mobilized their technical expertise to secure support for their projects. He also highlights the challenges associated with the commercialization of liquid crystals at RCA and Optel—the RCA spin-off that ultimately manufactured the first LCD wristwatch. The TVs of Tomorrow is a detailed portrait of American innovation during the Cold War, which confirms that success in the electronics industry hinges upon input from both the laboratory and the boardroom.

Today's science tells us that our bodies are filled with molecular machinery that orchestrates all sorts of life processes. When we think, microscopic "channels" open and close in our brain cell membranes; when we run, tiny "motors" spin in our muscle cell membranes; and when we see, light operates "molecular switches" in our eyes and nerves. A molecular-mechanical vision of life has become commonplace in both the halls of philosophy and the offices of drug companies, where researchers are developing “proton pump inhibitors” or medicines similar to Prozac.  Membranes to Molecular Machines explores just how late twentieth-century science came to think of our cells and bodies this way. This story is told through the lens of membrane research, an unwritten history at the crossroads of molecular biology, biochemistry, physiology, and the neurosciences, that directly feeds into today's synthetic biology as well as nano- and biotechnology. Mathias Grote shows how these sciences not only have made us think differently about life, they have, by reworking what membranes and proteins represent in laboratories, allowed us to manipulate life as "active matter" in new ways. Covering the science of biological membranes in the United States and Europe from the mid-1960s to the 1990s, this book connects that history to contemporary work with optogenetics, a method for stimulating individual neurons using light, and will enlighten and provoke anyone interested in the intersection of chemical research and the life sciences—from practitioner to historian to philosopher.The research described in the book and its central actor, Dieter Oesterhelt, were honored with the 2021 Albert Lasker Basic Medical Research Award for his contribution to the development of optogenetics.

The first book-length history of gems in early modern science offers a thought-provoking new take on the Scientific Revolution.  In Gems and the New Science, Michael Bycroft argues that gems were connected to major developments in the “new science” between the sixteenth and nineteenth centuries. As he explains, precious and semiprecious stones were at the center of dramatic shifts in natural knowledge in early modern Europe. They were used to investigate luminescence, electricity, combustion, chemical composition, and more. They were collected by naturalists; measured by mathematicians; and rubbed, burned, and dissolved by experimental philosophers. This led to the demise of the traditional way of classifying gems—which grouped them by transparency, color, and locality—and the turn to density, refraction, chemistry, and crystallography as more reliable guides for sorting these substances.  The science of gems shows that material evaluation was as important as material production in the history of science. It also shows the value of seeing science as the product of the interaction between different material worlds. The book begins by bringing these insights to bear on five themes of the Scientific Revolution. Each of the subsequent chapters deals with a major episode in early modern science, from the expansion of natural history in the sixteenth century to the emergence of applied science early in the nineteenth century. This important work is not only the first book-length history of the science of gems but also a fresh interpretation of the Scientific Revolution and an argument for using a new form of materialism to understand the evolution of science.

Harold C. Urey (1893-1981) was one of the most famous American scientists of the twentieth century. Awarded the Nobel Prize in 1934 for his discovery of deuterium and heavy water, Urey later participated in the Manhattan Project and NASA's lunar exploration program. In this, the first ever biography of the chemist, Matthew Shindell shines new light on Urey's achievements and efforts to shape his public and private lives.Shindell follows Urey through his orthodox religious upbringing, the scientific work that won him the Nobel, and his subsequent efforts to use his fame to intervene in political, social, and scientific matters. At times, Urey succeeded, including when he helped create the fields of isotope geochemistry and cosmochemistry. But other endeavors, such as his promotion of world governance of atomic weapons, failed. By exploring those efforts, as well as Urey's evolution from farm boy to scientific celebrity, we can discern broader changes in the social and intellectual landscape of twentieth-century America. More than a life story, this book immerses readers in the struggles and triumphs of not only an extraordinary man, but also his extraordinary times.

In "Inventing Chemistry", historian John C. Powers turns his attention to Herman Boerhaave (1668-1738), a Dutch medical and chemical professor whose work reached a wide, educated audience and became the template for chemical knowledge in the eighteenth century. The primary focus of this study is Boerhaave's educational philosophy, and Powers traces its development from Boerhaave's early days as a student in Leiden through his publication of the Elementa chemiae in 1732. Powers reveals how Boerhaave restructured and reinterpreted various practices from diverse chemical traditions - including craft chemistry, Paracelsian medical chemistry, and alchemy - shaping them into a chemical course that conformed to the pedagogical and philosophical norms of Leiden's medical faculty. In doing so, Boerhaave gave his chemistry a coherent organizational structure and philosophical foundation and thus transformed an artisanal practice into an academic discipline. "Inventing Chemistry" will be essential reading for historians of chemistry, medicine, and academic life.

This book reevaluates the changes to chemistry that took place from 1660 to 1730 through a close study of the chymist Wilhelm Homberg (1653-1715) and the changing fortunes of his discipline at the Academie Royale des Sciences, France's official scientific body. By charting Homberg's remarkable life from Java to France's royal court, and his endeavor to create a comprehensive theory of chymistry (including alchemical transmutation), Lawrence M. Principe reveals the period's significance and reassesses its place in the broader sweep of the history of science.Principe, the leading authority on the subject, recounts how Homberg's radical vision promoted chymistry as the most powerful and reliable means of understanding the natural world. Homberg's work at the Academie and in collaboration with the future regent, Philippe II d'Orleans, as revealed by a wealth of newly uncovered documents, provides surprising new insights onto the broader changes chymistry underwent during and immediately after Homberg. A human, disciplinary, and institutional biography, The Transmutations of Chymistry significantly revises what was previously known about the contours of chymistry and scientific institutions in the early eighteenth century.

During most of the nineteenth century, physicians and pharmacists alike considered medical patenting and the use of trademarks by drug manufacturers unethical forms of monopoly; physicians who prescribed patented drugs could be, and were, ostracized from the medical community. In the decades following the Civil War, however, complex changes in patent and trademark law intersected with the changing sensibilities of both physicians and pharmacists to make intellectual property rights in drug manufacturing scientifically and ethically legitimate. By World War I, patented and trademarked drugs had become essential to the practice of good medicine, aiding in the rise of the American pharmaceutical industry and forever altering the course of medicine.            Drawing on a wealth of previously unused archival material, Medical Monopoly combines legal, medical, and business history to offer a sweeping new interpretation of the origins of the complex and often troubling relationship between the pharmaceutical industry and medical practice today. Joseph M. Gabriel provides the first detailed history of patent and trademark law as it relates to the nineteenth-century pharmaceutical industry as well as a unique interpretation of medical ethics, therapeutic reform, and the efforts to regulate the market in pharmaceuticals before World War I. His book will be of interest not only to historians of medicine and science and intellectual property scholars but also to anyone following contemporary debates about the pharmaceutical industry, the patenting of scientific discoveries, and the role of advertising in the marketplace.

Chemists in the nineteenth century were faced with a particular problem: how to depict the atoms and molecules beyond the direct reach of our bodily senses. In visualizing this microworld, these scientists were the first to move beyond high-level philosophical speculations regarding the unseen. In "Image and Reality", Alan J. Rocke focuses on the community of organic chemists in Germany to provide the basis for a fuller understanding of the nature of scientific creativity. Arguing that visual mental images assisted many of these scientists in thinking through old problems and new possibilities, Rocke uses a variety of sources, including private correspondence, diagrams and illustrations, scientific papers, and public statements to investigate their ability to not only imagine the invisibly tiny atoms and molecules upon which they operated daily, but to build detailed and empirically based pictures of them. These portrayals of 'chemical structures' gradually became an accepted part of science and are now regarded as one of the defining features of chemistry.In telling this fascinating story, Rocke also suggests that imagistic thinking is often at the heart of creative thinking in all fields.

We live in a world saturated by chemicals--our food, our clothes, and even our bodies play host to hundreds of synthetic chemicals that did not exist before the nineteenth century. By the 1900s, a wave of bright coal tar dyes had begun to transform the western world. Originally intended for textiles, the new dyes soon permeated daily life in unexpected ways, and by the time the risks and uncertainties surrounding the synthesized chemicals began to surface, they were being used in everything from clothes and home furnishings to cookware and food. In A Rainbow Palate, Carolyn Cobbold explores how the widespread use of new chemical substances influenced perceptions and understanding of food, science, and technology, as well as trust in science and scientists. Because the new dyes were among the earliest contested chemical additives in food, the battles surrounding their use offer striking insights and parallels into today's international struggles surrounding chemical, food, and trade regulation.

For centuries, historians have speculated about the life of Katherine Jones, Lady Ranelagh. Dominant depictions show her either as a maternal figure to her younger brother Robert Boyle, one of the most significant scientists of his day, or as a patroness of the European correspondence network now known as the Hartlib circle—but neither portrait captures the depth of her intellect or the range of her knowledge and influence.  Philosophers, mathematicians, politicians, and religious authorities sought her opinion on everything from decimalizing the currency to producing Hebrew grammars. She practiced medicine alongside distinguished male physicians, treating some of the most elite patients in London. Her medical recipes, political commentaries, and testimony concerning the philosophers’ stone gained international circulation. She was an important influence on Boyle and a formidable thinker in her own right.  Drawing from a wealth of new archival sources, Michelle DiMeo fills out Lady Ranelagh’s legacy in the context of a historically sensitive and nuanced interpretation of gender, science, and religion. The book re-creates the intellectual life of one of the most respected and influential women in seventeenth-century Europe, revealing how she managed to gain the admiration of diverse contemporaries, effect social change, and shape contemporary science.

In 1524, Pope Clement VII gave two condemned criminals to his physician to test a promising new antidote. After each convict ate a marzipan cake poisoned with deadly aconite, one of them received the antidote, and lived—the other died in agony. In sixteenth-century Europe, this and more than a dozen other accounts of poison trials were committed to writing. Alisha Rankin tells their little-known story.At a time when poison was widely feared, the urgent need for effective cures provoked intense excitement about new drugs. As doctors created, performed, and evaluated poison trials, they devoted careful attention to method, wrote detailed experimental reports, and engaged with the problem of using human subjects for fatal tests. In reconstructing this history, Rankin reveals how the antidote trials generated extensive engagement with “experimental thinking” long before the great experimental boom of the seventeenth century and investigates how competition with lower-class healers spurred on this trend.The Poison Trials sheds welcome and timely light on the intertwined nature of medical innovations, professional rivalries, and political power.

In 1524, Pope Clement VII gave two condemned criminals to his physician to test a promising new antidote. After each convict ate a marzipan cake poisoned with deadly aconite, one of them received the antidote, and lived—the other died in agony. In sixteenth-century Europe, this and more than a dozen other accounts of poison trials were committed to writing. Alisha Rankin tells their little-known story.At a time when poison was widely feared, the urgent need for effective cures provoked intense excitement about new drugs. As doctors created, performed, and evaluated poison trials, they devoted careful attention to method, wrote detailed experimental reports, and engaged with the problem of using human subjects for fatal tests. In reconstructing this history, Rankin reveals how the antidote trials generated extensive engagement with “experimental thinking” long before the great experimental boom of the seventeenth century and investigates how competition with lower-class healers spurred on this trend.The Poison Trials sheds welcome and timely light on the intertwined nature of medical innovations, professional rivalries, and political power.

The first in-depth study of Japanese fermentation science in the twentieth century.The Arts of the Microbial World explores the significance of fermentation phenomena, both as life processes and as technologies, in Japanese scientific culture. Victoria Lee’s careful study documents how Japanese scientists and skilled workers sought to use the microbe’s natural processes to create new products, from soy-sauce mold starters to MSG, vitamins to statins. In traditional brewing houses as well as in the food, fine chemical, and pharmaceutical industries across Japan, they showcased their ability to deal with the enormous sensitivity and variety of the microbial world. Charting developments in fermentation science from the turn of the twentieth century, when Japan was an industrializing country on the periphery of the world economy, to 1980 when it had emerged as a global technological and economic power, Lee highlights the role of indigenous techniques in modern science as it took shape in Japan. In doing so, she reveals how knowledge of microbes lay at the heart of some of Japan’s most prominent technological breakthroughs in the global economy.At a moment when twenty-first-century developments in the fields of antibiotic resistance, the microbiome, and green chemistry suggest that the traditional eradication-based approach to the microbial world is unsustainable, twentieth-century Japanese microbiology provides a new, broader vantage for understanding and managing microbial interactions with society.

A 400-year history of the development of alchemy in England that brings to light the evolution of the practice.In medieval and early modern Europe, the practice of alchemy promised extraordinary physical transformations. Who would not be amazed to see base metals turned into silver and gold, hard iron into soft water, and deadly poison into elixirs that could heal the human body? To defend such claims, alchemists turned to the past, scouring ancient books for evidence of a lost alchemical heritage and seeking to translate their secret language and obscure imagery into replicable, practical effects.Tracing the development of alchemy in England over four hundred years, from the beginning of the fourteenth century to the end of the seventeenth, Jennifer M. Rampling illuminates the role of alchemical reading and experimental practice in the broader context of national and scientific history. Using new manuscript sources, she shows how practitioners like George Ripley, John Dee, and Edward Kelley, as well as many previously unknown alchemists, devised new practical approaches to alchemy while seeking the support of English monarchs. By reconstructing their alchemical ideas, practices, and disputes, Rampling reveals how English alchemy was continually reinvented over the space of four centuries, resulting in changes to the science itself. In so doing, The Experimental Fire bridges the intellectual history of chemistry and the wider worlds of early modern patronage, medicine, and science.

A surprising look at how modern capitalism changed sugar from a natural food to a scientific commodity.Sugar is everywhere in the western diet, blamed for epidemics of obesity, diabetes, and other modern maladies. Our addiction to sweetness has a long and unsavory history. Over the past five hundred years, sugar has shaped empires, made fortunes for a few, and brought misery for millions of workers both enslaved and free. How did sugar become a defining modern food and an essential global commodity?In Unrefined, David Singerman recasts our thinking about this crucial substance in the history of capitalism. Before the nineteenth century, sugar’s value depended on natural qualities: its color, its taste, where it was grown, and who had made it. But beginning around 1850, a combination of plantation owners, industrialists, and scientists set out to redefine sugar itself. Deploying the tools and rhetoric of science, they transformed not just how sugar was produced or traded but even how people thought about it. By changing sugar into a pure chemical object, these forces stripped power from workers and enabled—and obscured—new kinds of fraud, corruption, and monopoly.Taking us to unexplored spaces in the world of sugar, from laboratories and docks to refineries and the halls of Congress, Singerman illuminates dark intersections of the histories of corruption, science, and capitalism.

A biography of Henry Edward Armstrong, an underappreciated maverick in the history of chemistry.  Fifth Business is a biography of the English chemist, educator, and scientific critic Henry Edward Armstrong. Today, Armstrong, who was a central figure in the development of the science of chemistry between 1885 and 1914, is more remembered for his campaigns to improve the teaching of chemistry, and science generally, and less for his theory of residual affinity and reverse electrolysis—or his hostility toward physical chemistry. However, right up until his retirement, Armstrong was a significant and prolific organic chemist, as well as a major figure in the academic and social life of the Chemical Society. Fifth Business is structured as chronologically as possible, with Armstrong’s life and achievements as an active chemist in Part I (1848–1911) and as a critic in his long retirement in Part II (1911–1937). Brock’s authoritative biography provides a unique inside look at its subject, allowing us to better understand the history of British science, scientific institutions, scientific education, pedagogical theory, and social relations of science during the last third of the nineteenth century and the first third of the twentieth.

How an early modern surgeon and his accessible writings changed medical expertise and the communication of medical knowledge.   Between 1497 and 1512, Hieronymus Brunschwig (ca. 1450–ca. 1530), an obscure craftsman from Strasbourg, wrote books on surgery and pharmacy that transformed medical expertise, how it was codified in print, and how it was communicated to new audiences. Brunschwig was an unlikely author. He apprenticed as a surgeon in the local guild and dispensed medicines from his own shop. But he was remarkably well-read in surgery, alchemy, and medical theory, even if he lacked a university education. His unique authorial voice spoke to the healing practices of craftsmen and common people in a down-to-earth German dialect.  Crafting Medicine, by Tillmann Taape, is the first in-depth study of Brunschwig and his works. In it, Taape argues that Brunschwig’s writings shaped a nascent tradition of vernacular medicine. Brunschwig’s books represent a key moment in the history of medical print, for they conveyed medical expertise to a new readership of nonacademic practitioners, who became a key audience for a flood of vernacular medical publications during the sixteenth century. Using Brunschwig’s books as a unique window into the past, Crafting Medicine beautifully reconstructs the world of science inhabited by Brunschwig, his fellow craftsmen, his translators, and his readers.

How an early modern surgeon and his accessible writings changed medical expertise and the communication of medical knowledge.   Between 1497 and 1512, Hieronymus Brunschwig (ca. 1450–ca. 1530), an obscure craftsman from Strasbourg, wrote books on surgery and pharmacy that transformed medical expertise, how it was codified in print, and how it was communicated to new audiences. Brunschwig was an unlikely author. He apprenticed as a surgeon in the local guild and dispensed medicines from his own shop. But he was remarkably well-read in surgery, alchemy, and medical theory, even if he lacked a university education. His unique authorial voice spoke to the healing practices of craftsmen and common people in a down-to-earth German dialect.  Crafting Medicine, by Tillmann Taape, is the first in-depth study of Brunschwig and his works. In it, Taape argues that Brunschwig’s writings shaped a nascent tradition of vernacular medicine. Brunschwig’s books represent a key moment in the history of medical print, for they conveyed medical expertise to a new readership of nonacademic practitioners, who became a key audience for a flood of vernacular medical publications during the sixteenth century. Using Brunschwig’s books as a unique window into the past, Crafting Medicine beautifully reconstructs the world of science inhabited by Brunschwig, his fellow craftsmen, his translators, and his readers.