Chapman & Hall/CRC Biostatistics Series – serie
Visar alla böcker i serien Chapman & Hall/CRC Biostatistics Series. Handla med fri frakt och snabb leverans.
302 produkter
Real-World Evidence in Drug Development and Evaluation
Av Harry Yang, Binbing Yu
Inbunden, 2021
2197 kr
Lägg i varukorg
Real-world evidence (RWE) has been at the forefront of pharmaceutical innovations. It plays an important role in transforming drug development from a process aimed at meeting regulatory expectations to an operating model that leverages data from disparate sources to aid business, regulatory, and …
Cure Models
Methods, Applications, and Implementation
Inbunden, 2021
1882 kr
Lägg i varukorg
Cure Models: Methods, Applications and Implementation is the first book in the last 25 years that provides a comprehensive and systematic introduction to the basics of modern cure models, including estimation, inference, and software. This book is useful for statistical researchers and graduate …
Model-Assisted Bayesian Designs for Dose Finding and Optimization
Methods and Applications
Av Ying Yuan, Ruitao Lin m. fl.
Inbunden, 2022
1567 kr
Lägg i varukorg
Bayesian adaptive designs provide a critical approach to improve the efficiency and success of drug development that has been embraced by the US Food and Drug Administration (FDA). This is particularly important for early phase trials as they form the basis for the development and success of …
Advanced Survival Models
Inbunden, 2021
2197 kr
Lägg i varukorg
Survival data analysis is a very broad field of statistics, encompassing a large variety of methods used in a wide range of applications, and in particular in medical research. During the last twenty years, several extensions of "classical" survival models have been developed to address particular …
Analysis of Incidence Rates
Inbunden, 2019
2512 kr
Lägg i varukorg
Incidence rates are counts divided by person-time; mortality rates are a well-known example. Analysis of Incidence Rates offers a detailed discussion of the practical aspects of analyzing incidence rates. Important pitfalls and areas of controversy are discussed. The text is aimed at graduate …
Applied Meta-Analysis with R and Stata
Av Ding-Geng (Din) Chen, Karl E. Peace
Inbunden, 2021
2197 kr
Lägg i varukorg
Review of the First Edition:The authors strive to reduce theory to a minimum, which makes it a self-learning text that is comprehensible for biologists, physicians, etc. who lack an advanced mathematics background. Unlike in many other textbooks, R is not introduced with meaningless toy examples; …
Controlled Epidemiological Studies
Av Marie Reilly
Inbunden, 2023
2197 kr
Lägg i varukorg
This book covers classic epidemiological designs that use a reference/control group, including case-control, case-cohort, nested case-control and variations of these designs, such as stratified and two-stage designs. It presents a unified view of these sampling designs as representations of an …
Signal Detection for Medical Scientists
Likelihood Ratio Test-based Methodology
Av Ram Tiwari, Jyoti Zalkikar m. fl.
Inbunden, 2021
2197 kr
Lägg i varukorg
Signal Detection for Medical Scientists: Likelihood Ratio Based Test-Based Methodology presents the data mining techniques with focus on likelihood ratio test (LRT) based methods for signal detection. It emphasizes computational aspect of LRT methodology and is pertinent for first-time researchers …
Innovative Statistics in Regulatory Science
Inbunden, 2019
2197 kr
Lägg i varukorg
Statistical methods that are commonly used in the review and approval process of regulatory submissions are usually referred to as statistics in regulatory science or regulatory statistics. In a broader sense, statistics in regulatory science can be defined as valid statistics that are employed in …
Cancer Clinical Trials
Current and Controversial Issues in Design and Analysis
Av Stephen L. George, Xiaofei Wang m. fl.
Häftad, 2019
832 kr
Lägg i varukorg
Cancer Clinical Trials: Current and Controversial Issues in Design and Analysis provides statisticians with an understanding of the critical challenges currently encountered in oncology trials. Well-known statisticians from academic institutions, regulatory and government agencies (such as the U.S. …
Clinical Trial Optimization Using R
Av Alex Dmitrienko, Erik Pulkstenis
Häftad, 2019
832 kr
Lägg i varukorg
Clinical Trial Optimization Using R explores a unified and broadly applicable framework for optimizing decision making and strategy selection in clinical development, through a series of examples and case studies. It provides the clinical researcher with a powerful evaluation paradigm, as well as …
Data and Safety Monitoring Committees in Clinical Trials
Av Jay Herson
Häftad, 2019
808 kr
Lägg i varukorg
Praise for the first edition:"Given the author’s years of experience as a statistician and as a founder of the first DMC in pharmaceutical industry trials, I highly recommend this book—not only for experts because of its cogent and organized presentation, but more importantly for young …
Geospatial Health Data
Modeling and Visualization with R-INLA and Shiny
Av Paula Moraga
Inbunden, 2019
1562 kr
Lägg i varukorg
Geospatial health data are essential to inform public health and policy. These data can be used to quantify disease burden, understand geographic and temporal patterns, identify risk factors, and measure inequalities. Geospatial Health Data: Modeling and Visualization with R-INLA and Shiny …
Artificial Intelligence for Drug Development, Precision Medicine, and Healthcare
Av Mark Chang
Inbunden, 2020
2126 kr
Lägg i varukorg
Artificial Intelligence for Drug Development, Precision Medicine, and Healthcare covers exciting developments at the intersection of computer science and statistics. While much of machine-learning is statistics-based, achievements in deep learning for image and language processing rely on computer …
Statistical Methods for Mediation, Confounding and Moderation Analysis Using R and SAS
Av Qingzhao Yu, Bin Li
Inbunden, 2022
2504 kr
Lägg i varukorg
Third-variable effect refers to the effect transmitted by third-variables that intervene in the relationship between an exposure and a response variable. Differentiating between the indirect effect of individual factors from multiple third-variables is a constant problem for modern …
Empirical Likelihood Method in Survival Analysis
Av Mai Zhou
Häftad, 2019
1038 kr
Lägg i varukorg
Add the Empirical Likelihood to Your Nonparametric ToolboxEmpirical Likelihood Method in Survival Analysis explains how to use the empirical likelihood method for right censored survival data. The author uses R for calculating empirical likelihood and includes many worked out examples with the …
Bayesian Modeling in Bioinformatics
Av Dipak K. Dey, Samiran Ghosh m. fl.
Häftad, 2019
1038 kr
Lägg i varukorg
Bayesian Modeling in Bioinformatics discusses the development and application of Bayesian statistical methods for the analysis of high-throughput bioinformatics data arising from problems in molecular and structural biology and disease-related medical research, such as cancer. It presents a broad …
Elementary Bayesian Biostatistics
Häftad, 2019
1098 kr
Lägg i varukorg
Bayesian analyses have made important inroads in modern clinical research due, in part, to the incorporation of the traditional tools of noninformative priors as well as the modern innovations of adaptive randomization and predictive power. Presenting an introductory perspective to modern Bayesian …
Applied Statistical Designs for the Researcher
Häftad, 2019
1038 kr
Lägg i varukorg
Showcasing a discussion of the experimental process and a review of basic statistics, this volume provides methodologies to identify general data distribution, skewness, and outliers. It features a unique classification of the nonparametric analogs of their parametric counterparts according to the …
Generalized Linear Models
A Bayesian Perspective
Av Dipak K. Dey, Sujit K. Ghosh m. fl.
Häftad, 2019
1038 kr
Lägg i varukorg
This volume describes how to conceptualize, perform, and critique traditional generalized linear models (GLMs) from a Bayesian perspective and how to use modern computational methods to summarize inferences using simulation. Introducing dynamic modeling for GLMs and containing over 1000 references …
Meta-Analysis in Medicine and Health Policy
Av Dalene Stangl, Donald A. Berry
Häftad, 2019
1067 kr
Lägg i varukorg
This remarkable text raises the analysis of data in health sciences and policy to new heights of refinement and applicability by introducing cutting-edge meta-analysis strategies while reviewing more commonly used techniques. Each chapter builds on sound principles, develops methodologies to solve …
R for Health Technology Assessment
Av Gianluca Baio, Howard Thom m. fl.
Inbunden, 2025
1876 kr
Lägg i varukorg
R for Health Technology Assessment discusses the use of proper statistical software, specifically R, to perform the whole pipeline of analytic modelling in health technology assessment (HTA). It has been designed with the objective of establishing the use of R as the standard tool for HTA amongst …
Medical Statistics for Cancer Studies
Inbunden, 2022
1562 kr
Lägg i varukorg
Cancer is a dreaded disease. One in two people will be diagnosed with cancer within their lifetime. Medical Statistics for Cancer Studies shows how cancer data can be analysed in a variety of ways, covering cancer clinical trial data, epidemiological data, biological data, and genetic data. It …
Interface between Regulation and Statistics in Drug Development
Av Demissie Alemayehu, Birol Emir m. fl.
Inbunden, 2020
2190 kr
Lägg i varukorg
With the critical role of statistics in the design, conduct, analysis and reporting of clinical trials or observational studies intended for regulatory purposes, numerous guidelines have been issued by regulatory authorities around the world focusing on statistical issues related to drug …
Innovative Methods for Rare Disease Drug Development
Inbunden, 2020
2126 kr
Lägg i varukorg
In the United States, a rare disease is defined by the Orphan Drug Act as a disorder or condition that affects fewer than 200,000 persons. For the approval of "orphan" drug products for rare diseases, the traditional approach of power analysis for sample size calculation is not feasible because …
Innovative Methods for Rare Disease Drug Development
Häftad, 2022
791 kr
Lägg i varukorg
In the United States, a rare disease is defined by the Orphan Drug Act as a disorder or condition that affects fewer than 200,000 persons. For the approval of "orphan" drug products for rare diseases, the traditional approach of power analysis for sample size calculation is not feasible because …
Drug Development for Rare Diseases
Inbunden, 2023
2190 kr
Lägg i varukorg
A disease is defined as rare if the prevalence is fewer than 200,000 in the United States. It is estimated that there are more than 7,000 rare diseases, which collectively affect 30 million Americans or 10% of the US population. This diverse and complex disease area poses challenges for patients, …
Advanced Statistics in Regulatory Critical Clinical Initiatives
Av Wei Zhang, Fangrong Yan m. fl.
Inbunden, 2022
2818 kr
Lägg i varukorg
Advanced Statistics in Regulatory Critical Clinical Initiatives is focused on the critical clinical initiatives introduced by the 21st Century Cure Act passed by the United States Congress in December 2016. The book covers everything from the outline of the initiatives to analysis on the effect on …
Simultaneous Global New Drug Development
Multi-Regional Clinical Trials after ICH E17
Av Gang Li, Bruce Binkowitz m. fl.
Inbunden, 2021
2818 kr
Lägg i varukorg
Global simultaneous development is becoming more necessary as the cost of developing medical products continues to grow. The strategy of using multiregional clinical trials (MRCTs) has become the preferred method for developing new medicines. Implementing the same protocol to include subjects from …
Medical Product Safety Evaluation
Biological Models and Statistical Methods
Av Jie Chen, Joseph Heyse m. fl.
Häftad, 2020
814 kr
Lägg i varukorg
Medical Product Safety Evaluation: Biological Models and Statistical Methods presents cutting-edge biological models and statistical methods that are tailored to specific objectives and data types for safety analysis and benefit-risk assessment. Some frequently encountered issues and challenges in …
