Chapman & Hall/CRC Interdisciplinary Statistics – serie

The book's website (with databases and other support materials) can be accessed here.Praise for the Second Edition:The second edition introduces an especially broad set of statistical methods … As a lecturer in both transportation and marketing research, I find this book an excellent textbook for advanced undergraduate, Master’s and Ph.D. students, covering topics from simple descriptive statistics to complex Bayesian models. … It is one of the few books that cover an extensive set of statistical methods needed for data analysis in transportation. The book offers a wealth of examples from the transportation field. —The American Statistician Statistical and Econometric Methods for Transportation Data Analysis, Third Editionoffers an expansion over the first and second editions in response to the recent methodological advancements in the fields of econometrics and statistics and to provide an increasing range of examples and corresponding data sets. It describes and illustrates some of the statistical and econometric tools commonly used in transportation data analysis. It provides a wide breadth of examples and case studies, covering applications in various aspects of transportation planning, engineering, safety, and economics. Ample analytical rigor is provided in each chapter so that fundamental concepts and principles are clear and numerous references are provided for those seeking additional technical details and applications. New to the Third Edition Updated references and improved examples throughout. New sections on random parameters linear regression and ordered probability models including the hierarchical ordered probit model. A new section on random parameters models with heterogeneity in the means and variances of parameter estimates. Multiple new sections on correlated random parameters and correlated grouped random parameters in probit, logit and hazard-based models. A new section discussing the practical aspects of random parameters model estimation. A new chapter on Latent Class Models. A new chapter on Bivariate and Multivariate Dependent Variable Models. Statistical and Econometric Methods for Transportation Data Analysis, Third Editioncan serve as a textbook for advanced undergraduate, Masters, and Ph.D. students in transportation-related disciplines including engineering, economics, urban and regional planning, and sociology. The book also serves as a technical reference for researchers and practitioners wishing to examine and understand a broad range of statistical and econometric tools required to study transportation problems.

Applied sciences, both physical and social, such as atmospheric, biological, climate, demographic, economic, ecological, environmental, oceanic and political, routinely gather large volumes of spatial and spatio-temporal data in order to make wide ranging inference and prediction. Ideally such inferential tasks should be approached through modelling, which aids in estimation of uncertainties in all conclusions drawn from such data. Unified Bayesian modelling, implemented through user friendly software packages, provides a crucial key to unlocking the full power of these methods for solving challenging practical problems.Key features of the book:• Accessible detailed discussion of a majority of all aspects of Bayesian methods and computations with worked examples, numerical illustrations and exercises• A spatial statistics jargon buster chapter that enables the reader to build up a vocabulary without getting clouded in modeling and technicalities• Computation and modeling illustrations are provided with the help of the dedicated R package bmstdr, allowing the reader to use well-known packages and platforms, such as rstan, INLA, spBayes, spTimer, spTDyn, CARBayes, CARBayesST, etc• Included are R code notes detailing the algorithms used to produce all the tables and figures, with data and code available via an online supplement• Two dedicated chapters discuss practical examples of spatio-temporal modeling of point referenced and areal unit data• Throughout, the emphasis has been on validating models by splitting data into test and training sets following on the philosophy of machine learning and data scienceThis book is designed to make spatio-temporal modeling and analysis accessible and understandable to a wide audience of students and researchers, from mathematicians and statisticians to practitioners in the applied sciences. It presents most of the modeling with the help of R commands written in a purposefully developed R package to facilitate spatio-temporal modeling. It does not compromise on rigour, as it presents the underlying theories of Bayesian inference and computation in standalone chapters, which would be appeal those interested in the theoretical details. By avoiding hard core mathematics and calculus, this book aims to be a bridge that removes the statistical knowledge gap from among the applied scientists.

Mendelian Randomization: Methods For Causal Inference Using Genetic Variants provides thorough coverage of the methods and practical elements of Mendelian randomization analysis. It brings together diverse aspects of Mendelian randomization from the fields of epidemiology, statistics, genetics, and bioinformatics.Through multiple examples, the first part of the book introduces the reader to the concept of Mendelian randomization, showing how to perform simple Mendelian randomization investigations and interpret the results. The second part of the book addresses specific methodological issues relevant to the practice of Mendelian randomization, including robust methods, weak instruments, multivariable methods, and power calculations. The authors present the theoretical aspects of these issues in an easy-to-understand way by using non-technical language. The last part of the book examines the potential for Mendelian randomization in the future, exploring both methodological and applied developments.FeaturesOffers first-hand, in-depth guidance on Mendelian randomization from leaders in the fieldMakes the diverse aspects of Mendelian randomization understandable to newcomersIllustrates technical details using data from applied analysesDiscusses possible future directions for research involving Mendelian randomizationSoftware code is provided in the relevant chapters and is also available at the supplementary websiteThis book gives epidemiologists, statisticians, geneticists, and bioinformaticians the foundation to understand how to use genetic variants as instrumental variables in observational data.New in Second Edition: The second edition of the book has been substantially re-written to reduce the amount of technical content, and emphasize practical consequences of theoretical issues. Extensive material on the use of two-sample Mendelian randomization and publicly-available summarized data has been added. The book now includes several real-world examples that show how Mendelian randomization can be used to address questions of disease aetiology, target validation, and drug development

Due to the tremendous accumulation of data for genetic markers, pharmacogenomics, the study of the functions and interactions of all genes in the overall variability of drug response, is one of the hottest areas of research in biomedical science. Statistical and Computational Pharmacogenomics presents recent developments in statistical methodology with a number of detailed worked examples that outline how these methods can be applied. This comprehensive volume provides key tools needed to understand and model the genetic variation for drug response and equips statisticians with a thorough understanding of this complex field and how computational skills can be employed.

Providing reliable information on an intervention effect, meta-analysis is a powerful statistical tool for analyzing and combining results from individual studies. Meta-Analysis of Binary Data Using Profile Likelihood focuses on the analysis and modeling of a meta-analysis with individually pooled data (MAIPD). It presents a unifying approach to modeling a treatment effect in a meta-analysis of clinical trials with binary outcomes.After illustrating the meta-analytic situation of an MAIPD with several examples, the authors introduce the profile likelihood model and extend it to cope with unobserved heterogeneity. They describe elements of log-linear modeling, ways for finding the profile maximum likelihood estimator, and alternative approaches to the profile likelihood method. The authors also discuss how to model covariate information and unobserved heterogeneity simultaneously and use the profile likelihood method to estimate odds ratios. The final chapters look at quantifying heterogeneity in an MAIPD and show how meta-analysis can be applied to the surveillance of scrapie. Containing new developments not available in the current literature, along with easy-to-follow inferences and algorithms, this book enables clinicians to efficiently analyze MAIPDs.

Statistical analyses of the numbers, lengths, and orientations of fission tracks etched in minerals yield dating and thermal history information valuable in geological and geoscience applications, particularly in oil exploration. Fission tracks can be represented mathematically by a stochastic process of randomly oriented line segments in three dimensions, and this "line segment" model can describe and explain the essential statistical features of the data, providing a rigorous foundation for quantitative modelling and simulation studies.Statistics for Fission Track Analysis explores the line segment model and its consequences for the analysis and interpretation of data. The author derives the equations for fission track data and the theoretical probability distributions for the number, orientation, and length measurements of the tracks. He sets out the theory of fission track dating and through numerical examples, presents methods for analyzing and interpreting fission track counts. Later chapters address statistical models for situations in which samples contain mixtures of fission track ages. These methods, along with observation features of the various measurements, are illustrated by real examples. Finally, the author brings together the theoretical and observation aspects to formulate a joint likelihood function of counts, lengths, and angles as a basis for parametric thermal history modelling. An appendix provides general notes on statistical concepts and methods.Designed for broad accessibility, this is the first book to fully cover the statistical foundations of fission track analysis. Whether you work in a fission track lab, in archaeological, geological, or geochronological research, or in geological applications of statistics, you will find the background material and practical tools you need to optimize the use of fission track analysis in your work and to make further advances in the field.

Natural scientists perceive and classify organisms primarily on the basis of their appearance and structure- their form , defined as that characteristic remaining invariant after translation, rotation, and possibly reflection of the object. The quantitative study of form and form change comprises the field of morphometrics. For morphometrics to succeed, it needs techniques that not only satisfy mathematical and statistical rigor but also attend to the scientific issues.An Invariant Approach to the Statistical Analysis of Shapes results from a long and fruitful collaboration between a mathematical statistician and a biologist. Together they have developed a methodology that addresses the importance of scientific relevance, biological variability, and invariance of the statistical and scientific inferences with respect to the arbitrary choice of the coordinate system. They present the history and foundations of morphometrics, discuss the various kinds of data used in the analysis of form, and provide justification for choosing landmark coordinates as a preferred data type. They describe the statistical models used to represent intra-population variability of landmark data and show that arbitrary translation, rotation, and reflection of the objects introduce infinitely many nuisance parameters. The most fundamental part of morphometrics-comparison of forms-receives in-depth treatment, as does the study of growth and growth patterns, classification, clustering, and asymmetry.Morphometrics has only recently begun to consider the invariance principle and its implications for the study of biological form. With the advantage of dual perspectives, An Invariant Approach to the Statistical Analysis of Shapes stands as a unique and important work that brings a decade's worth of innovative methods, observations, and insights to an audience of both statisticians and biologists.

Statistical and mathematical models are defined by parameters that describe different characteristics of those models. Ideally it would be possible to find parameter estimates for every parameter in that model, but, in some cases, this is not possible. For example, two parameters that only ever appear in the model as a product could not be estimated individually; only the product can be estimated. Such a model is said to be parameter redundant, or the parameters are described as non-identifiable. This book explains why parameter redundancy and non-identifiability is a problem and the different methods that can be used for detection, including in a Bayesian context. Key features of this book: Detailed discussion of the problems caused by parameter redundancy and non-identifiability Explanation of the different general methods for detecting parameter redundancy and non-identifiability, including symbolic algebra and numerical methods Chapter on Bayesian identifiability Throughout illustrative examples are used to clearly demonstrate each problem and method. Maple and R code are available for these examples More in-depth focus on the areas of discrete and continuous state-space models and ecological statistics, including methods that have been specifically developed for each of these areasThis book is designed to make parameter redundancy and non-identifiability accessible and understandable to a wide audience from masters and PhD students to researchers, from mathematicians and statisticians to practitioners using mathematical or statistical models.

Survival Analysis with Interval-Censored Data: A Practical Approach with Examples in R, SAS, and BUGS provides the reader with a practical introduction into the analysis of interval-censored survival times. Although many theoretical developments have appeared in the last fifty years, interval censoring is often ignored in practice. Many are unaware of the impact of inappropriately dealing with interval censoring. In addition, the necessary software is at times difficult to trace. This book fills in the gap between theory and practice. Features:-Provides an overview of frequentist as well as Bayesian methods.-Include a focus on practical aspects and applications.-Extensively illustrates the methods with examples using R, SAS, and BUGS. Full programs are available on a supplementary website.The authors:Kris Bogaerts is project manager at I-BioStat, KU Leuven. He received his PhD in science (statistics) at KU Leuven on the analysis of interval-censored data. He has gained expertise in a great variety of statistical topics with a focus on the design and analysis of clinical trials.Arnošt Komárek is associate professor of statistics at Charles University, Prague. His subject area of expertise covers mainly survival analysis with the emphasis on interval-censored data and classification based on longitudinal data. He is past chair of the Statistical Modelling Society and editor of Statistical Modelling: An International Journal.Emmanuel Lesaffre is professor of biostatistics at I-BioStat, KU Leuven. His research interests include Bayesian methods, longitudinal data analysis, statistical modelling, analysis of dental data, interval-censored data, misclassification issues, and clinical trials. He is the founding chair of the Statistical Modelling Society, past-president of the International Society for Clinical Biostatistics, and fellow of ISI and ASA.

Modern Directional Statistics collects important advances in methodology and theory for directional statistics over the last two decades. It provides a detailed overview and analysis of recent results that can help both researchers and practitioners. Knowledge of multivariate statistics eases the reading but is not mandatory.The field of directional statistics has received a lot of attention over the past two decades, due to new demands from domains such as life sciences or machine learning, to the availability of massive data sets requiring adapted statistical techniques, and to technological advances. This book covers important progresses in distribution theory,high-dimensional statistics, kernel density estimation, efficient inference on directional supports, and computational and graphical methods. Christophe Ley is professor of mathematical statistics at Ghent University. His research interests include semi-parametrically efficient inference, flexible modeling, directional statistics and the study of asymptotic approximations via Stein’s Method. His achievements include the Marie-Jeanne Laurent-Duhamel prize of the Société Française de Statistique and an elected membership at the International Statistical Institute. He is associate editor for the journals Computational Statistics & Data Analysis and Econometrics and Statistics.Thomas Verdebout is professor of mathematical statistics at Université libre de Bruxelles (ULB). His main research interests are semi-parametric statistics, high- dimensional statistics, directional statistics and rank-based procedures. He has won an annual prize of the Belgian Academy of Sciences and is an elected member of the International Statistical Institute. He is associate editor for the journals Statistics and Probability Letters and Journal of Multivariate Analysis.

The widespread popularity of geographic information systems (GIS) has led to new insights in countless areas of application. It has facilitated not only the collection and storage of geographic data, but also the display of such data. Building on this progress by using an integrated approach, Statistical Detection and Monitoring of Geographic Clusters provides the statistical tools to identify whether data on a given map deviates significantly from expectations and to determine quickly whether new point patterns are emerging over time. The book begins with a review of statistical methods for cluster detection, organized according to the different types of hypotheses and questions about clustering that can be investigated. It then delineates methods that allow for the quick detection of emergent geographic clusters.The book delivers a cohesive presentation unlike that of most edited volumes. Drawing on the authors' extensive work in the field, the book delineates methods in such a way that they can be applied, almost instantly, to an array of disciplines. The readily applicable methods the book describes are useful for a multitude of problems in a variety of fields, particularly disease surveillance in the public health industry. Statistical Detection and Monitoring of Geographic Clusters is an essential volume for your reference shelf.

Data collected in psychiatry and related fields are complex because outcomes are rarely directly observed, there are multiple correlated repeated measures within individuals, there is natural heterogeneity in treatment responses and in other characteristics in the populations.Simple statistical methods do not work well with such data. More advanced statistical methods capture the data complexity better, but are difficult to apply appropriately and correctly by investigators who do not have advanced training in statistics.This book presents, at a non-technical level, several approaches for the analysis of correlated data: mixed models for continuous and categorical outcomes, nonparametric methods for repeated measures and growth mixture models for heterogeneous trajectories over time. Separate chapters are devoted to techniques for multiple comparison correction, analysis in the presence of missing data, adjustment for covariates, assessment of mediator and moderator effects, study design and sample size considerations. The focus is on the assumptions of each method, applicability and interpretation rather than on technical details.FeaturesProvides an overview of intermediate to advanced statistical methods applied to psychiatry. Takes a non-technical approach with mathematical details kept to a minimum. Includes lots of detailed examples from published studies in psychiatry and related fields. Software programs, data sets and output are available on a supplementary website. The intended audience are applied researchers with minimal knowledge of statistics, although the book could also benefit collaborating statisticians. The book, together with the online materials, is a valuable resource aimed at promoting the use of appropriate statistical methods for the analysis of repeated measures data.Ralitza Gueorguieva is a Senior Research Scientist at the Department of Biostatistics, Yale School of Public Health. She has more than 20 years experience in statistical methodology development and collaborations with psychiatrists and other researchers, and is the author of over 130 peer-reviewed publications.

This book collects important advances in methodology and data analysis for directional statistics. It is the companion book of the more theoretical treatment presented in Modern Directional Statistics (CRC Press, 2017). The field of directional statistics has received a lot of attention due to demands from disciplines such as life sciences or machine learning, the availability of massive data sets requiring adapted statistical techniques, and technological advances. This book covers important progress in bioinformatics, biology, astrophysics, oceanography, environmental sciences, earth sciences, machine learning and social sciences.

The Data Book: Collection and Management of Research Data is the first practical book written for researchers and research team members covering how to collect and manage data for research. The book covers basic types of data and fundamentals of how data grow, move and change over time. Focusing on pre-publication data collection and handling, the text illustrates use of these key concepts to match data collection and management methods to a particular study, in essence, making good decisions about data.The first section of the book defines data, introduces fundamental types of data that bear on methodology to collect and manage them, and covers data management planning and research reproducibility. The second section covers basic principles of and options for data collection and processing emphasizing error resistance and traceability. The third section focuses on managing the data collection and processing stages of research such that quality is consistent and ultimately capable of supporting conclusions drawn from data. The final section of the book covers principles of data security, sharing, and archival. This book will help graduate students and researchers systematically identify and implement appropriate data collection and handling methods.

Missing Data Analysis in Practice provides practical methods for analyzing missing data along with the heuristic reasoning for understanding the theoretical underpinnings. Drawing on his 25 years of experience researching, teaching, and consulting in quantitative areas, the author presents both frequentist and Bayesian perspectives. He describes easy-to-implement approaches, the underlying assumptions, and practical means for assessing these assumptions. Actual and simulated data sets illustrate important concepts, with the data sets and codes available online.The book underscores the development of missing data methods and their adaptation to practical problems. It mainly focuses on the traditional missing data problem. The author also shows how to use the missing data framework in many other statistical problems, such as measurement error, finite population inference, disclosure limitation, combing information from multiple data sources, and causal inference.

Since the publication of the second edition, many new Bayesian tools and methods have been developed for space-time data analysis, the predictive modeling of health outcomes, and other spatial biostatistical areas. Exploring these new developments, Bayesian Disease Mapping: Hierarchical Modeling in Spatial Epidemiology, Third Edition provides an up-to-date, cohesive account of the full range of Bayesian disease mapping methods and applications. In addition to the new material, the book also covers more conventional areas such as relative risk estimation, clustering, spatial survival analysis, and longitudinal analysis. After an introduction to Bayesian inference, computation, and model assessment, the text focuses on important themes, including disease map reconstruction, cluster detection, regression and ecological analysis, putative hazard modeling, analysis of multiple scales and multiple diseases, spatial survival and longitudinal studies, spatiotemporal methods, and map surveillance. It shows how Bayesian disease mapping can yield significant insights into georeferenced health data. The target audience for this text is public health specialists, epidemiologists, and biostatisticians who need to work with geo-referenced health data.

Drawing on the author’s 45 years of experience in multivariate analysis, Correspondence Analysis in Practice, Third Edition, shows how the versatile method of correspondence analysis (CA) can be used for data visualization in a wide variety of situations. CA and its variants, subset CA, multiple CA and joint CA, translate two-way and multi-way tables into more readable graphical forms — ideal for applications in the social, environmental and health sciences, as well as marketing, economics, linguistics, archaeology, and more.Michael Greenacre is Professor of Statistics at the Universitat Pompeu Fabra, Barcelona, Spain, where he teaches a course, amongst others, on Data Visualization. He has authored and co-edited nine books and 80 journal articles and book chapters, mostly on correspondence analysis, the latest being Visualization and Verbalization of Data in 2015. He has given short courses in fifteen countries to environmental scientists, sociologists, data scientists and marketing professionals, and has specialized in statistics in ecology and social science.

Power Analysis of Trials with Multilevel Data covers using power and sample size calculations to design trials that involve nested data structures. The book gives a thorough overview of power analysis that details terminology and notation, outlines key concepts of statistical power and power analysis, and explains why they are necessary in trial design. It guides you in performing power calculations with hierarchical data, which enables more effective trial design.The authors are leading experts in the field who recognize that power analysis has attracted attention from applied statisticians in social, behavioral, medical, and health science. Their book supplies formulae that allow statisticians and researchers in these fields to perform calculations that enable them to plan cost-efficient trials. The formulae can also be applied to other sciences.Using power analysis in trial design is increasingly important in a scientific community where experimentation is often expensive, competition for funding among researchers is intense, and agencies that finance research require proposals to give thorough justification for funding. This handbook shows how power analysis shapes trial designs that have high statistical power and low cost, using real-life examples.The book covers multiple types of trials, including cluster randomized trials, multisite trials, individually randomized group treatment trials, and longitudinal intervention studies. It also offers insight on choosing which trial is best suited to a given project. Power Analysis of Trials with Multilevel Data helps you craft an optimal research design and anticipate the necessary sample size of data to collect to give your research maximum effectiveness and efficiency.

Statistics for Environmental Biology and Toxicology presents and illustrates statistical methods appropriate for the analysis of environmental data obtained in biological or toxicological experiments. Beginning with basic probability and statistical inferences, this text progresses through non-linear and generalized linear models, trend testing, time-to-event data and analysis of cross-classified tabular and categorical data. For the more complex analyses, extensive examples including SAS and S-PLUS programming code are provided to assist the reader when implementing the methods in practice.

Biology is in the midst of a era yielding many significant discoveries and promising many more. Unique to this era is the exponential growth in the size of information-packed databases. Inspired by a pressing need to analyze that data, Introduction to Computational Biology explores a new area of expertise that emerged from this fertile field- the combination of biological and information sciences.This introduction describes the mathematical structure of biological data, especially from sequences and chromosomes. After a brief survey of molecular biology, it studies restriction maps of DNA, rough landmark maps of the underlying sequences, and clones and clone maps. It examines problems associated with reading DNA sequences and comparing sequences to finding common patterns. The author then considers that statistics of pattern counts in sequences, RNA secondary structure, and the inference of evolutionary history of related sequences.Introduction to Computational Biology exposes the reader to the fascinating structure of biological data and explains how to treat related combinatorial and statistical problems. Written to describe mathematical formulation and development, this book helps set the stage for even more, truly interdisciplinary work in biology.

Natural scientists perceive and classify organisms primarily on the basis of their appearance and structure- their form , defined as that characteristic remaining invariant after translation, rotation, and possibly reflection of the object. The quantitative study of form and form change comprises the field of morphometrics. For morphometrics to succeed, it needs techniques that not only satisfy mathematical and statistical rigor but also attend to the scientific issues.An Invariant Approach to the Statistical Analysis of Shapes results from a long and fruitful collaboration between a mathematical statistician and a biologist. Together they have developed a methodology that addresses the importance of scientific relevance, biological variability, and invariance of the statistical and scientific inferences with respect to the arbitrary choice of the coordinate system. They present the history and foundations of morphometrics, discuss the various kinds of data used in the analysis of form, and provide justification for choosing landmark coordinates as a preferred data type. They describe the statistical models used to represent intra-population variability of landmark data and show that arbitrary translation, rotation, and reflection of the objects introduce infinitely many nuisance parameters. The most fundamental part of morphometrics-comparison of forms-receives in-depth treatment, as does the study of growth and growth patterns, classification, clustering, and asymmetry.Morphometrics has only recently begun to consider the invariance principle and its implications for the study of biological form. With the advantage of dual perspectives, An Invariant Approach to the Statistical Analysis of Shapes stands as a unique and important work that brings a decade's worth of innovative methods, observations, and insights to an audience of both statisticians and biologists.

A comprehensive summary of new and existing approaches to analyzing multiresponse data, Graphical Analysis of Multiresponse Data emphasizes graphical procedures. These procedures are then used, in various ways, to analyze, summarize, and present data from a specific, well-known plant breeding trial.These procedures result in overlap plots, their corresponding semigraphical tables, scatter plot matrices, profiles across environments and attributes for individual genotypes and groups of genotypes, and principal components.The interpretation of these displays, as an aid to understanding, is illustrated and discussed. Techniques for choosing expressions for the observed quantities are also emphasized.Graphical Analysis of Multiresponse Data is arranged into three parts:What can usefully be done Consequences for the example Approaches and choices in more detailThat structure enables the reader to obtain an overview of what can be found, and to then delve into various aspects more deeply if desired.Statisticians, data analysts, biometricians, plant breeders, behavioral scientists, social scientists, and engineering scientists will find Graphical Analysis of Multiresponse Data offers invaluable assistance. Its details are also of interest to scientists in private firms, government institutions, and research organizations who are concerned with the analysis and interpretation of experimental multiresponse data.

Mendelian Randomization: Methods For Causal Inference Using Genetic Variants provides thorough coverage of the methods and practical elements of Mendelian randomization analysis. It brings together diverse aspects of Mendelian randomization from the fields of epidemiology, statistics, genetics, and bioinformatics.Through multiple examples, the first part of the book introduces the reader to the concept of Mendelian randomization, showing how to perform simple Mendelian randomization investigations and interpret the results. The second part of the book addresses specific methodological issues relevant to the practice of Mendelian randomization, including robust methods, weak instruments, multivariable methods, and power calculations. The authors present the theoretical aspects of these issues in an easy-to-understand way by using non-technical language. The last part of the book examines the potential for Mendelian randomization in the future, exploring both methodological and applied developments.FeaturesOffers first-hand, in-depth guidance on Mendelian randomization from leaders in the fieldMakes the diverse aspects of Mendelian randomization understandable to newcomersIllustrates technical details using data from applied analysesDiscusses possible future directions for research involving Mendelian randomizationSoftware code is provided in the relevant chapters and is also available at the supplementary websiteThis book gives epidemiologists, statisticians, geneticists, and bioinformaticians the foundation to understand how to use genetic variants as instrumental variables in observational data.New in Second Edition: The second edition of the book has been substantially re-written to reduce the amount of technical content, and emphasize practical consequences of theoretical issues. Extensive material on the use of two-sample Mendelian randomization and publicly-available summarized data has been added. The book now includes several real-world examples that show how Mendelian randomization can be used to address questions of disease aetiology, target validation, and drug development

Model-based Geostatistics for Global Public Health: Methods and Applications provides an introductory account of model-based geostatistics, its implementation in open-source software and its application in public health research. In the public health problems that are the focus of this book, the authors describe and explain the pattern of spatial variation in a health outcome or exposure measurement of interest. Model-based geostatistics uses explicit probability models and established principles of statistical inference to address questions of this kind.Features: Presents state-of-the-art methods in model-based geostatistics. Discusses the application these methods some of the most challenging global public health problems including disease mapping, exposure mapping and environmental epidemiology. Describes exploratory methods for analysing geostatistical data, including: diagnostic checking of residuals standard linear and generalized linear models; variogram analysis; Gaussian process models and geostatistical design issues. Includes a range of more complex geostatistical problems where research is ongoing. All of the results in the book are reproducible using publicly available R code and data-sets, as well as a dedicated R package. This book has been written to be accessible not only to statisticians but also to students and researchers in the public health sciences.The AuthorsPeter Diggle is Distinguished University Professor of Statistics in the Faculty of Health and Medicine, Lancaster University. He also holds honorary positions at the Johns Hopkins University School of Public Health, Columbia University International Research Institute for Climate and Society, and Yale University School of Public Health. His research involves the development of statistical methods for analyzing spatial and longitudinal data and their applications in the biomedical and health sciences.Dr Emanuele Giorgi is a Lecturer in Biostatistics and member of the CHICAS research group at Lancaster University, where he formerly obtained a PhD in Statistics and Epidemiology in 2015. His research interests involve the development of novel geostatistical methods for disease mapping, with a special focus on malaria and other tropical diseases. In 2018, Dr Giorgi was awarded the Royal Statistical Society Research Prize "for outstanding published contribution at the interface of statistics and epidemiology." He is also the lead developer of PrevMap, an R package where all the methodology found in this book has been implemented.

Generalized Linear Models (GLMs) allow many statistical analyses to be extended to important statistical distributions other than the Normal distribution. While numerous books exist on how to analyse data using a GLM, little information is available on how to collect the data that are to be analysed in this way.This is the first book focusing specifically on the design of experiments for GLMs. Much of the research literature on this topic is at a high mathematical level, and without any information on computation. This book explains the motivation behind various techniques, reduces the difficulty of the mathematics, or moves it to one side if it cannot be avoided, and gives examples of how to write and run computer programs using R. Features The generalisation of the linear model to GLMs Background mathematics, and the use of constrained optimisation in R Coverage of the theory behind the optimality of a design Individual chapters on designs for data that have Binomial or Poisson distributions Bayesian experimental design An online resource contains R programs used in the bookThis book is aimed at readers who have done elementary differentiation and understand minimal matrix algebra, and have familiarity with R. It equips professional statisticians to read the research literature. Nonstatisticians will be able to design their own experiments by following the examples and using the programs provided.

Capture-recapture methods have been used in biology and ecology for more than 100 years. However, it is only recently that these methods have become popular in the social and medical sciences to estimate the size of elusive populations such as illegal immigrants, illicit drug users, or people with a drinking problem. Capture-Recapture Methods for the Social and Medical Sciences brings together important developments which allow the application of these methods. It has contributions from more than 40 researchers, and is divided into eight parts, including topics such as ratio regression models, capture-recapture meta-analysis, extensions of single and multiple source models, latent variable models and Bayesian approaches. The book is suitable for everyone who is interested in applying capture-recapture methods in the social and medical sciences. Furthermore, it is also of interest to those working with capture-recapture methods in biology and ecology, as there are some important developments covered in the book that also apply to these classical application areas.

Bayesian Analysis of Capture-Recapture Data with Hidden Markov Models: Theory and Case Studies in R and NIMBLE introduces ecologists and statisticians to a powerful and unifying framework for analyzing capture-recapture data. Hidden Markov models (HMMs) have become a cornerstone in modern population ecology, offering a flexible way to decompose complex processes such as survival, recruitment, and dispersal into simpler building blocks, while explicitly accounting for the fact that we only observe imperfect data rather than the true underlying states. Combined with Bayesian inference, HMMs provide a natural and transparent approach to handle uncertainty, explore model structures, and draw robust conclusions. This book illustrates how to bring these ideas to life using the R package NIMBLE, a fast-developing environment for building and fitting hierarchical models.Key Features:A clear introduction to the principles of Bayesian statistics, HMMs, and the NIMBLE packageStep-by-step tutorials showing how to implement a wide range of capture-recapture models for open populationsFully reproducible examples with data and R code, following a “learning by doing” philosophyCase studies drawn from the ecological literature, illustrating how to apply methods to real-world conservation questionsPractical guidance on model specification, coding strategies, and interpretation of resultsWritten in an accessible style, this book is designed for ecologists, wildlife biologists, and conservation scientists who already use R and wish to deepen their modeling toolkit, as well as statisticians interested in ecological applications. Beginners will find a self-contained path into Bayesian capture-recapture modeling, while experienced researchers will discover a flexible framework to extend and adapt to their own data and questions.

Missing data pose challenges to real-life data analysis. Simple ad-hoc fixes, like deletion or mean imputation, only work under highly restrictive conditions, which are often not met in practice. Multiple imputation replaces each missing value by multiple plausible values. The variability between these replacements reflects our ignorance of the true (but missing) value. Each of the completed data set is then analyzed by standard methods, and the results are pooled to obtain unbiased estimates with correct confidence intervals. Multiple imputation is a general approach that also inspires novel solutions to old problems by reformulating the task at hand as a missing-data problem.This is the second edition of a popular book on multiple imputation, focused on explaining the application of methods through detailed worked examples using the MICE package as developed by the author. This new edition incorporates the recent developments in this fast-moving field.This class-tested book avoids mathematical and technical details as much as possible: formulas are accompanied by verbal statements that explain the formula in accessible terms. The book sharpens the reader’s intuition on how to think about missing data, and provides all the tools needed to execute a well-grounded quantitative analysis in the presence of missing data.

Epilepsy research promises new treatments and insights into brain function, but statistics and machine learning are paramount for extracting meaning from data and enabling discovery. Statistical Methods in Epilepsy provides a comprehensive introduction to statistical methods used in epilepsy research. Written in a clear, accessible style by leading authorities, this textbook demystifies introductory and advanced statistical methods, providing a practical roadmap that will be invaluable for learners and experts alike.Topics include a primer on version control and coding, pre-processing of imaging and electrophysiological data, hypothesis testing, generalized linear models, survival analysis, network analysis, time-series analysis, spectral analysis, spatial statistics, unsupervised and supervised learning, natural language processing, prospective trial design, pharmacokinetic and pharmacodynamic modeling, and randomized clinical trials.Features:Provides a comprehensive introduction to statistical methods employed in epilepsy researchDivided into four parts: Basic Processing Methods for Data Analysis; Statistical Models for Epilepsy Data Types; Machine Learning Methods; and Clinical StudiesCovers methodological and practical aspects, as well as worked-out examples with R and Python code provided in the online supplementIncludes contributions by experts in the fieldhttps://github.com/sharon-chiang/Statistics-Epilepsy-Book/The handbook targets clinicians, graduate students, medical students, and researchers who seek to conduct quantitative epilepsy research. The topics covered extend broadly to quantitative research in other neurological specialties and provide a valuable reference for the field of neurology.